HitPredict

Interactor 1: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Interactor 2: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.612

The method score is based on:

Property	Details
Experiments	35271311, 20085707
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus and 6 others more... GO:0006974 - DNA damage response GO:0032991 - protein-containing complex GO:0042752 - regulation of circadian rhythm GO:0043065 - positive regulation of apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0048511 - rhythmic process
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	1531
Hs

1	4128

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024