Protein: SIR2
NAD-dependent histone deacetylase sir2 (EC 2.3.1.286) (Regulatory protein sir2) (Silent information regulator 2)

Gene: SIR2
Organism: Schizosaccharomyces pombe 972h-
Interactions: 14
UniProt ID: O94640

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0004407 - histone deacetylase activity
GO:0005634 - nucleus
GO:0005721 - pericentric heterochromatin
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

314630

DPB4
DNA polymerase epsilon subunit D

1

0

Small-scale

0.513

High

314629

H4
Histone H4

1

5

High-throughput

0.501

High

238022

CBH2
CENP-B homolog protein 2

1

1

High-throughput

0.481

High

267529

SOL1
SWI/SNF chromatin-remodeling complex subunit sol1

1

5

High-throughput

0.481

High

313957

IMA2
Importin subunit alpha-2

1

7

High-throughput

0.481

High

314632

YAWC
Uncharacterized bHLH domain-containing protein C3F10.12c

1

9

High-throughput

0.481

High

206365

FFT3
ATP-dependent helicase fft3

1

14

High-throughput

0.479

High

314631

RRP6
Exosome complex exonuclease rrp6

1

4

High-throughput

0.479

High

238102

YH7G
Putative transcriptional regulatory protein C16G5.16

1

0

High-throughput

0.460

High

314628

TAS3
RNA-induced transcriptional silencing complex protein tas3

1

0

High-throughput

0.460

High

314487

JHD1
Putative JmjC domain-containing histone demethylation protein 1

1

0

High-throughput

0.458

High

314634

MDV1
Mitochondrial division protein 1

1

6

High-throughput

0.439

High

314635

SWI5
Mating-type switching protein swi5

1

0

High-throughput

0.426

High

314633

MUG79
Meiotically up-regulated gene 79 protein

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025