Protein: JHD1
Putative JmjC domain-containing histone demethylation protein 1 (EC 1.14.11.27) (Heterochromatin-destabilizing protein epe1) ([Histone-H3]-lysine-36 demethylase 1)

Gene: JHD1
Organism: Schizosaccharomyces pombe 972h-
Interactions: 163
UniProt ID: O94603

Gene Ontology (top 5):
GO:0000792 - heterochromatin
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005721 - pericentric heterochromatin
GO:0006338 - chromatin remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

314499

SWI6
Chromatin-associated protein swi6

5

12

Small-scale

0.722

High

314505

H2AZ
Histone H2A.Z

1

1

High-throughput

0.618

High

314515

PHF1
SWM histone demethylase complex subunit phf1

1

0

High-throughput

0.586

High

314550

CDT2
Cell division cycle protein cdt2

1

6

Small-scale

0.573

High

206977

CHP2
Chromo domain-containing protein 2

1

9

Small-scale

0.561

High

238256

TAF10
SAGA complex/transcription factor TFIID complex subunit Taf10

2

0

Small-scale

0.559

High

267701

TAF6
SAGA complex/transcription factor TFIID complex subunit Taf6

2

0

Small-scale

0.559

High

267845

SNF1
SNF1-like protein kinase ssp2

2

0

Small-scale

0.559

High

314557

YK82
Bromodomain-containing protein C631.02

1

11

High-throughput

0.552

High

148824

TAF5
SAGA complex/transcription factor TFIID complex subunit Taf5

1

6

Small-scale

0.479

High

152018

SPT5
Transcription elongation factor spt5

1

4

High-throughput

0.479

High

152030

AP3B
AP-3 complex subunit beta

1

1

High-throughput

0.479

High

152734

RPA49
DNA-directed RNA polymerase I subunit rpa49

1

3

High-throughput

0.479

High

153549

MTR4
ATP-dependent RNA helicase mtr4

1

3

High-throughput

0.479

High

207018

DHX15
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43

1

4

High-throughput

0.479

High

207230

BTAF1
TATA-binding protein-associated factor mot1

1

1

High-throughput

0.479

High

238067

FKH2
Fork head protein homolog 2

1

4

High-throughput

0.479

High

238283

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.479

High

313617

CSK2C
Casein kinase II subunit beta-2

1

3

High-throughput

0.479

High

314486

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.479

High

314488

RPC1
DNA-directed RNA polymerase III subunit rpc1

1

3

High-throughput

0.479

High

314492

RPA1
DNA-directed RNA polymerase I subunit rpa1

1

3

High-throughput

0.479

High

314496

RPB1
DNA-directed RNA polymerase II subunit rpb1

1

3

High-throughput

0.479

High

314498

CSK2A
Casein kinase II subunit alpha

1

9

High-throughput

0.479

High

314500

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

314501

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

314502

SMC4
Structural maintenance of chromosomes protein 4

1

1

High-throughput

0.479

High

314509

CLR3
Histone deacetylase clr3

1

1

High-throughput

0.479

High

314513

SPT7
SAGA complex subunit Spt7

1

15

Small-scale

0.479

High

314517

CLF1
Pre-mRNA-splicing factor cwf4

1

3

High-throughput

0.479

High

314518

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.479

High

314523

DBP10
ATP-dependent RNA helicase dbp10

1

4

High-throughput

0.479

High

314524

UBP8
Probable ubiquitin carboxyl-terminal hydrolase 8

1

1

Small-scale

0.479

High

314525

DBP5
ATP-dependent RNA helicase dbp5

1

2

High-throughput

0.479

High

314533

DRS1
ATP-dependent RNA helicase drs1

1

4

High-throughput

0.479

High

314536

HAS1
ATP-dependent RNA helicase has1

1

3

High-throughput

0.479

High

314537

FAL1
ATP-dependent RNA helicase fal1

1

1

High-throughput

0.479

High

314548

YDE1
Probable ubiquitin fusion degradation protein C12B10.01c

1

6

High-throughput

0.479

High

314549

GSK3
Protein kinase gsk3

1

1

High-throughput

0.479

High

314552

RFA2
Replication factor A protein 2

1

1

High-throughput

0.479

High

314553

RIF1
Telomere length regulator protein rif1

1

1

High-throughput

0.479

High

314554

YK16
Putative ATP-dependent RNA helicase PB1A10.06c

1

3

High-throughput

0.479

High

314555

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit Tra1

1

1

Small-scale

0.479

High

314556

YO48
Putative nucleosome assembly protein C36B7.08c

1

1

High-throughput

0.479

High

314559

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16

1

4

High-throughput

0.479

High

314560

YKU5
Uncharacterized WD repeat-containing protein C2E1P5.05

1

6

High-throughput

0.479

High

314561

GAD8
Serine/threonine-protein kinase gad8

1

1

High-throughput

0.479

High

314562

SYF1
Pre-mRNA-splicing factor cwf3

1

2

High-throughput

0.479

High

314578

BRR2
Pre-mRNA-splicing factor brr2

1

5

High-throughput

0.479

High

314582

DBP4
ATP-dependent RNA helicase dbp4

1

3

High-throughput

0.479

High

314584

UBP71
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.479

High

314585

RSE1
Pre-mRNA-splicing factor prp12

1

1

High-throughput

0.479

High

314589

GCN5
Histone acetyltransferase gcn5

1

9

Small-scale

0.479

High

314591

BDF1
SWR1 complex bromodomain subunit bdf1

1

10

High-throughput

0.479

High

151133

TAF12
SAGA complex/transcription factor TFIID complex subunit Taf12

1

0

Small-scale

0.458

High

151295

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.458

High

151932

SA114
Pre-mRNA-splicing factor sap114

1

0

High-throughput

0.458

High

152457

YEG9
Uncharacterized oxidoreductase C26H5.09c

1

0

High-throughput

0.458

High

152468

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

152478

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.458

High

152958

ELF1
mRNA export factor elf1

1

0

High-throughput

0.458

High

153342

SPT20
SAGA complex subunit Spt20

1

0

Small-scale

0.458

High

154376

SSR2
SWI/SNF and RSC complexes subunit ssr2

1

0

High-throughput

0.458

High

237580

SAP61
Pre-mRNA-splicing factor sap61

1

0

High-throughput

0.458

High

237786

SLT11
Pre-mRNA-splicing factor cwf5

1

0

High-throughput

0.458

High

237969

SPT8
SAGA complex subunit Spt8

1

0

Small-scale

0.458

High

267588

YJL2
Uncharacterized protein C14G10.02

1

0

High-throughput

0.458

High

267594

YJL4
Uncharacterized protein C14G10.04

1

0

High-throughput

0.458

High

267773

LSM7
LSM complex subunit lsm7

1

0

High-throughput

0.458

High

267792

EKC1
Extragenic suppressor of kinetochore protein 1

1

0

High-throughput

0.458

High

268359

CAF1
Poly(A) ribonuclease pop2

1

0

High-throughput

0.458

High

268492

RRP45
Exosome complex component rrp45

1

0

High-throughput

0.458

High

268807

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.458

High

313651

HFI1
SAGA complex subunit Hfi1

1

0

Small-scale

0.458

High

314147

YFE9
Uncharacterized exonuclease C637.09

1

0

High-throughput

0.458

High

314487

SIR2
NAD-dependent histone deacetylase sir2

1

0

High-throughput

0.458

High

314490

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

0

High-throughput

0.458

High

314491

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.458

High

314493

DBP2
ATP-dependent RNA helicase dbp2

1

0

High-throughput

0.458

High

314494

SPI1
GTP-binding nuclear protein spi1

1

0

High-throughput

0.458

High

314495

MCM3
DNA replication licensing factor mcm3

1

0

High-throughput

0.458

High

314497

U2AF2
Splicing factor U2AF 59 kDa subunit

1

0

High-throughput

0.458

High

314503

RNA1
Ran GTPase-activating protein 1

1

0

High-throughput

0.458

High

314504

RES2
Cell division cycle-related protein res2/pct1

1

0

High-throughput

0.458

High

314510

YGNB
Putative nucleosome assembly protein C2D10.11C

1

0

High-throughput

0.458

High

314512

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

314516

RIX1
Pre-rRNA-processing protein rix1

1

0

High-throughput

0.458

High

314520

RNP24
RNA-binding protein rnp24

1

0

High-throughput

0.458

High

314521

CDB4
Curved DNA-binding protein

1

0

High-throughput

0.458

High

314522

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.458

High

314526

FIP1X
Pre-mRNA polyadenylation factor fip1

1

0

High-throughput

0.458

High

314527

SDS23
Protein sds23/moc1

1

0

High-throughput

0.458

High

314531

PRP45
Pre-mRNA-processing protein 45

1

0

High-throughput

0.458

High

314534

PSI1
Protein psi1

1

0

High-throughput

0.458

High

314535

SPT6
Transcription elongation factor spt6

1

0

High-throughput

0.458

High

314538

RRP6
Exosome complex exonuclease rrp6

1

0

High-throughput

0.458

High

314539

FKBPH
Probable peptidyl-prolyl cis-trans isomerase C27F1.06c

1

0

High-throughput

0.458

High

314541

PTA1
mRNA cleavage and polyadenylation specificity factor complex subunit pta1

1

0

High-throughput

0.458

High

314543

PAC2
cAMP-independent regulatory protein pac2

1

0

High-throughput

0.458

High

314545

EXO70
Exocyst complex component exo70

1

0

High-throughput

0.458

High

314546

SDA1
Protein sda1

1

0

High-throughput

0.458

High

314551

NACB
Nascent polypeptide-associated complex subunit beta

1

0

High-throughput

0.458

High

314563

YIFC
PDZ domain-containing protein C23G3.12c

1

0

High-throughput

0.458

High

314564

TAF4
Transcription initiation factor TFIID subunit 4

1

0

High-throughput

0.458

High

314567

YJU3
Uncharacterized protein P25A2.03

1

0

High-throughput

0.458

High

314569

MU190
Meiotically up-regulated gene 190 protein

1

0

High-throughput

0.458

High

314573

NGG1
SAGA complex subunit Ngg1

1

0

Small-scale

0.458

High

314574

SGF29
SAGA complex subunit Sgf29

1

0

Small-scale

0.458

High

314575

RU2A
U2 small nuclear ribonucleoprotein A'

1

0

High-throughput

0.458

High

314576

RPA34
DNA-directed RNA polymerase I subunit rpa34

1

0

High-throughput

0.458

High

314577

2AAA
Protein phosphatase PP2A regulatory subunit A

1

0

High-throughput

0.458

High

314579

SEB1
Rpb7-binding protein seb1

1

0

High-throughput

0.458

High

314580

MKT1
Post-transcriptional regulator mkt1

1

0

High-throughput

0.458

High

314581

SNF21
Chromatin structure-remodeling complex subunit snf21

1

0

High-throughput

0.458

High

314583

ARP9
SWI/SNF and RSC complexes subunit arp9

1

0

High-throughput

0.458

High

314587

CDC73
Cell division control protein 73

1

0

High-throughput

0.458

High

314588

SA145
Pre-mRNA-splicing factor sap145

1

0

High-throughput

0.458

High

314590

SWI1
Mating-type switching protein swi1

1

0

High-throughput

0.458

High

314593

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

151855

YEX2
Uncharacterized WD repeat-containing protein C1A6.02

1

7

High-throughput

0.437

High

207307

AP1B1
AP-1 complex subunit beta-1

1

1

High-throughput

0.437

High

237767

CASP
Protein CASP

1

2

High-throughput

0.437

High

238036

YG65
Uncharacterized helicase C15C4.05

1

1

High-throughput

0.437

High

267919

POB1
Protein pob1

1

1

High-throughput

0.437

High

267929

SNU13
13 kDa ribonucleoprotein-associated protein

1

1

High-throughput

0.437

High

268786

PRP39
Pre-mRNA-processing factor 39

1

3

High-throughput

0.437

High

314519

PRH1
Probable ATP-dependent RNA helicase prh1

1

4

High-throughput

0.437

High

314532

SID2
Serine/threonine-protein kinase sid2

1

3

High-throughput

0.437

High

314540

DBP3
ATP-dependent RNA helicase dbp3

1

1

High-throughput

0.437

High

314542

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.437

High

314547

SCK2
Serine/threonine-protein kinase sck2

1

1

High-throughput

0.437

High

314565

YIW2
Uncharacterized helicase C694.02

1

4

High-throughput

0.437

High

314566

RPA2
Probable DNA-directed RNA polymerase I subunit RPA2

1

2

High-throughput

0.437

High

151408

RCQ1
Ribosome quality control complex subunit 1

1

0

High-throughput

0.249

Low

151720

YE0C
Uncharacterized FAD-binding protein C17H9.12c

1

0

High-throughput

0.249

Low

151912

EDC4L
Enhancer of mRNA-decapping protein 4-like protein pdc1

1

0

High-throughput

0.249

Low

153391

SPP42
Pre-mRNA-splicing factor spp42

1

0

High-throughput

0.249

Low

153639

TR120
Transport protein particle subunit trs120

1

0

High-throughput

0.249

Low

154007

SCE3
Probable RNA-binding protein sce3

1

0

High-throughput

0.249

Low

267670

STS5
Protein sts5

1

0

High-throughput

0.249

Low

267753

ATPO
ATP synthase subunit 5, mitochondrial

1

0

High-throughput

0.249

Low

268126

ALY2
Putative arrestin-related trafficking adapter C2D10.04

1

0

High-throughput

0.249

Low

314081

MUG87
Meiotically up-regulated gene 87 protein

1

0

High-throughput

0.249

Low

314199

PUF3
mRNA-binding protein puf3

1

0

High-throughput

0.249

Low

314269

CWF11
Pre-mRNA-splicing factor cwf11

1

0

High-throughput

0.249

Low

314355

PAM17
Presequence translocated-associated motor subunit pam17, mitochondrial

1

0

High-throughput

0.249

Low

314489

AP3M
AP-3 complex subunit mu

1

0

High-throughput

0.249

Low

314506

STE20
Serine/threonine-protein kinase shk1/pak1

1

0

High-throughput

0.249

Low

314507

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

0

High-throughput

0.249

Low

314508

IF2B
Probable eukaryotic translation initiation factor 2 subunit beta

1

0

High-throughput

0.249

Low

314511

EIF3J
Probable eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.249

Low

314514

YB0G
Probable ADP-ribosylation factor-binding protein C25H2.16c

1

0

High-throughput

0.249

Low

314528

YAG1
Uncharacterized WD repeat-containing protein C12G12.01c

1

0

High-throughput

0.249

Low

314529

RCL1
rRNA processing protein rcl1

1

0

High-throughput

0.249

Low

314530

YAG7
Uncharacterized protein C12G12.07c

1

0

High-throughput

0.249

Low

314544

PEX11
Peroxisomal biogenesis factor 11

1

0

High-throughput

0.249

Low

314558

YLI2
Uncharacterized protein C458.02c

1

0

High-throughput

0.249

Low

314568

YIE2
SH3 domain-containing protein PJ696.02

1

0

High-throughput

0.249

Low

314570

RQC2
Ribosome quality control complex subunit 2

1

0

High-throughput

0.249

Low

314571

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.249

Low

314572

STT4
Phosphatidylinositol 4-kinase stt4

1

0

High-throughput

0.249

Low

314586

AP1G1
AP-1 complex subunit gamma-1

1

0

High-throughput

0.249

Low

314592

YCJE
Uncharacterized protein C63.14

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025