Protein: PUS4
tRNA pseudouridine synthase 4 (EC 5.4.99.25) (tRNA pseudouridine(55) synthase) (Psi55 synthase) (tRNA pseudouridylate synthase 4) (tRNA-uridine isomerase 4)

Gene: PUS4
Organism: Saccharomyces cerevisiae S288C
Interactions: 51
UniProt ID: P48567

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0006400 - tRNA modification
GO:0009982 - pseudouridine synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

874305

PUS4
tRNA pseudouridine synthase 4

1

2

High-throughput

0.665

High

382944

RMAR
Small ribosomal subunit protein uS3m

2

0

High-throughput

0.559

High

874306

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.553

High

819205

SSB2
Ribosome-associated molecular chaperone SSB2

2

5

High-throughput

0.552

High

802520

SYSM
Serine--tRNA ligase, mitochondrial

1

1

High-throughput

0.515

High

704624

SBA1
Co-chaperone protein SBA1

1

0

Small-scale

0.504

High

656811

KC12
Casein kinase I homolog 2

1

0

High-throughput

0.480

High

394705

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.479

High

531554

RT02
Small ribosomal subunit protein uS14m

1

1

High-throughput

0.479

High

594454

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

705653

HIBCH
Small ribosomal subunit protein mS47

1

3

High-throughput

0.479

High

707584

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

709868

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

747139

RT04
Small ribosomal subunit protein uS2m

1

4

High-throughput

0.479

High

754490

RT05
Small ribosomal subunit protein uS5m

1

4

High-throughput

0.479

High

793797

RT09
Small ribosomal subunit protein uS9m

1

2

High-throughput

0.479

High

865987

RT26
Small ribosomal subunit protein mS42

1

1

High-throughput

0.479

High

866088

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.479

High

874310

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.479

High

874311

RT19
Small ribosomal subunit protein uS19m

1

2

High-throughput

0.479

High

874313

SWS2
Small ribosomal subunit protein uS13m

1

1

High-throughput

0.479

High

874314

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

874317

RT10
Small ribosomal subunit protein uS10m

1

2

High-throughput

0.479

High

874318

RT17
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.479

High

874321

RRS1
Regulator of ribosome biosynthesis

1

2

High-throughput

0.470

High

531489

RT01
Small ribosomal subunit protein mS43

1

0

High-throughput

0.458

High

554517

RT13
Small ribosomal subunit protein mS27

1

0

High-throughput

0.458

High

605393

RTPT
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

640722

RT28
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.458

High

699515

NAM9
Small ribosomal subunit protein uS4m

1

0

High-throughput

0.458

High

705094

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.458

High

780413

RT22
Ribosome assembly protein RSM22, mitochondrial

1

0

High-throughput

0.458

High

794901

RT21
Small ribosomal subunit protein bS21m

1

0

High-throughput

0.458

High

804049

FYV4
Small ribosomal subunit protein mS41

1

0

High-throughput

0.458

High

817363

RSM18
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.458

High

825505

RT25
Small ribosomal subunit protein mS23

1

0

High-throughput

0.458

High

843301

RT18
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.458

High

864089

AIM23
Altered inheritance of mitochondria protein 23, mitochondrial

1

0

High-throughput

0.458

High

874307

RT35
Small ribosomal subunit protein mS45

1

0

High-throughput

0.458

High

874308

RT27
Small ribosomal subunit protein mS33

1

0

High-throughput

0.458

High

874309

SPC98
Spindle pole body component SPC98

1

0

High-throughput

0.458

High

874315

RT23
Small ribosomal subunit protein mS29

1

0

High-throughput

0.458

High

874316

RT51
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.458

High

874319

RSM28
Small ribosomal subunit protein mS46

1

0

High-throughput

0.458

High

874320

RT24
Small ribosomal subunit protein mS35

1

0

High-throughput

0.458

High

545489

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

741933

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

268891

MRP10
Small ribosomal subunit protein mS37

1

0

High-throughput

0.249

Low

427584

RLA1
Large ribosomal subunit protein P1A

1

0

High-throughput

0.249

Low

874312

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025