Protein: HEM4
Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase)

Gene: HEM4, Mgu
Organism: Homo sapiens
Interactions: 12
UniProt ID: P10746

Gene Ontology (top 5):
GO:0004852 - uroporphyrinogen-III synthase activity
GO:0005542 - folic acid binding
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006780 - uroporphyrinogen III biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

532149

GSH0
Glutamate--cysteine ligase regulatory subunit

3

0

High-throughput

0.638

High

532155

MOCS1
Molybdenum cofactor biosynthesis protein 1

3

0

High-throughput

0.638

High

532156

BOLA1
BolA-like protein 1

3

0

High-throughput

0.638

High

285050

EED
Polycomb protein EED

2

0

High-throughput

0.576

High

532148

PLPL4
Patatin-like phospholipase domain-containing protein 4

1

0

High-throughput

0.513

High

532153

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

532154

UBQL4
Ubiquilin-4

1

0

High-throughput

0.486

High

532152

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

1

High-throughput

0.479

High

334146

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.458

High

532151

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.458

High

532150

TCAL1
Transcription elongation factor A protein-like 1

3

0

High-throughput

0.347

High

303059

CCN5
CCN family member 5

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025