Protein: ATG7
Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (hAGP7) (Ubiquitin-activating enzyme E1-like protein)

Gene: ATG7
Organism: Homo sapiens
Interactions: 153
UniProt ID: O95352

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000407 - phagophore assembly site
GO:0000423 - mitophagy
GO:0005576 - extracellular region
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

334252

ATG3
Ubiquitin-like-conjugating enzyme ATG3

7

7

Small-scale

0.964

High

334239

MLP3B
Microtubule-associated protein 1 light chain 3 beta

7

18

Small-scale

0.962

High

334242

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

7

18

Small-scale

0.961

High

327708

GBRAP
Gamma-aminobutyric acid receptor-associated protein

4

18

Small-scale

0.914

High

334241

ATG10
Ubiquitin-like-conjugating enzyme ATG10

4

7

High-throughput

0.903

High

334166

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

3

18

Small-scale

0.886

High

334234

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

2

18

Small-scale

0.825

High

334240

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

2

18

Small-scale

0.825

High

334136

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

2

14

Small-scale

0.737

High

317599

ATG12
Ubiquitin-like protein ATG12

3

3

Small-scale

0.664

High

334175

FOXO1
Forkhead box protein O1

4

0

Small-scale

0.648

High

334224

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

1

Small-scale

0.641

High

334230

LGMN
Legumain

3

0

High-throughput

0.638

High

334183

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

4

High-throughput

0.628

High

334187

TRIP6
Thyroid receptor-interacting protein 6

2

1

High-throughput

0.628

High

334203

NAA40
N-alpha-acetyltransferase 40

2

1

High-throughput

0.628

High

334211

TXLNB
Beta-taxilin

2

1

High-throughput

0.628

High

240370

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.618

High

314979

RECQ4
ATP-dependent DNA helicase Q4

2

2

High-throughput

0.611

High

334153

RHG25
Rho GTPase-activating protein 25

3

4

High-throughput

0.609

High

334163

ALR
FAD-linked sulfhydryl oxidase ALR

2

0

High-throughput

0.602

High

334216

STXB6
Syntaxin-binding protein 6

2

0

High-throughput

0.602

High

334269

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

0

High-throughput

0.602

High

334148

IRF2
Interferon regulatory factor 2

1

3

High-throughput

0.586

High

334173

KPCD
Protein kinase C delta type

2

2

Small-scale

0.584

High

334151

EF1D
Elongation factor 1-delta

1

1

High-throughput

0.578

High

334208

MICU2
Calcium uptake protein 2, mitochondrial

2

1

High-throughput

0.574

High

334237

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

2

Small-scale

0.561

High

171646

GAK
Cyclin-G-associated kinase

1

2

High-throughput

0.536

High

322687

RHBT3
Rho-related BTB domain-containing protein 3

1

4

High-throughput

0.536

High

322887

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

2

High-throughput

0.536

High

334149

CCND1
G1/S-specific cyclin-D1

1

2

High-throughput

0.536

High

334150

DPOD1
DNA polymerase delta catalytic subunit

1

2

High-throughput

0.536

High

334154

CASP2
Caspase-2

1

1

High-throughput

0.536

High

334155

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

1

High-throughput

0.536

High

334159

ERF
ETS domain-containing transcription factor ERF

1

1

High-throughput

0.536

High

334160

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

1

High-throughput

0.536

High

334178

TRI32
E3 ubiquitin-protein ligase TRIM32

1

3

High-throughput

0.536

High

334181

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

High-throughput

0.536

High

334184

PEX6
Peroxisomal ATPase PEX6

1

6

High-throughput

0.536

High

334189

EMAL3
Echinoderm microtubule-associated protein-like 3

1

1

High-throughput

0.536

High

334206

CEP97
Centrosomal protein of 97 kDa

1

1

High-throughput

0.536

High

334210

RPTOR
Regulatory-associated protein of mTOR

1

1

High-throughput

0.536

High

334217

NEDD1
Protein NEDD1

1

1

High-throughput

0.536

High

334220

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

2

High-throughput

0.536

High

334226

FXL18
F-box/LRR-repeat protein 18

1

1

High-throughput

0.536

High

334229

IF140
Intraflagellar transport protein 140 homolog

1

3

High-throughput

0.536

High

334231

ACBD6
Acyl-CoA-binding domain-containing protein 6

1

3

High-throughput

0.536

High

334233

TCAB1
Telomerase Cajal body protein 1

1

1

High-throughput

0.536

High

334235

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.536

High

334248

IF122
Intraflagellar transport protein 122 homolog

1

1

High-throughput

0.536

High

334249

WDR6
tRNA

1

2

High-throughput

0.536

High

334256

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

1

High-throughput

0.536

High

334258

RN181
E3 ubiquitin-protein ligase RNF181

1

1

High-throughput

0.536

High

334264

TTF2
Transcription termination factor 2

1

6

High-throughput

0.536

High

334141

P53
Cellular tumor antigen p53

1

3

Small-scale

0.534

High

334179

TADBP
TAR DNA-binding protein 43

1

1

High-throughput

0.515

High

48129

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.513

High

135860

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

0

High-throughput

0.513

High

213024

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.513

High

322356

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.513

High

334139

TTHY
Transthyretin

1

0

High-throughput

0.513

High

334145

TSP1
Thrombospondin-1

1

0

High-throughput

0.513

High

334152

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.513

High

334167

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.513

High

334168

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.513

High

334169

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.513

High

334170

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.513

High

334171

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

334180

CLN3
Battenin

1

0

High-throughput

0.513

High

334185

CND1
Condensin complex subunit 1

1

0

High-throughput

0.513

High

334186

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.513

High

334188

CTC1
CST complex subunit CTC1

1

0

High-throughput

0.513

High

334192

DNLZ
DNL-type zinc finger protein

1

0

High-throughput

0.513

High

334196

MAP1S
Microtubule-associated protein 1S

1

0

High-throughput

0.513

High

334197

HAUS3
HAUS augmin-like complex subunit 3

1

0

High-throughput

0.513

High

334199

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

High-throughput

0.513

High

334201

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.513

High

334202

TEDC1
Tubulin epsilon and delta complex protein 1

1

0

High-throughput

0.513

High

334204

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.513

High

334209

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

0

High-throughput

0.513

High

334212

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

334215

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.513

High

334219

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

1

0

High-throughput

0.513

High

334223

HPS3
BLOC-2 complex member HPS3

1

0

High-throughput

0.513

High

334228

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

0

High-throughput

0.513

High

334232

SPXN
Spexin

1

0

High-throughput

0.513

High

334236

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

334243

FA83D
Protein FAM83D

1

0

High-throughput

0.513

High

334246

ZN703
Zinc finger protein 703

1

0

High-throughput

0.513

High

334247

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

0

High-throughput

0.513

High

334250

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.513

High

334253

SMC4
Structural maintenance of chromosomes protein 4

1

0

High-throughput

0.513

High

334254

RNF12
E3 ubiquitin-protein ligase RLIM

1

0

High-throughput

0.513

High

334255

UCKL1
Uridine-cytidine kinase-like 1

1

0

High-throughput

0.513

High

334257

TRM1
tRNA

1

0

High-throughput

0.513

High

334265

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

334266

FBX7
F-box only protein 7

1

0

High-throughput

0.513

High

334268

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.513

High

334142

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

334174

EP300
Histone acetyltransferase p300

1

0

Small-scale

0.493

High

295718

AP1G2
AP-1 complex subunit gamma-like 2

1

1

High-throughput

0.489

High

326638

DUS14
Dual specificity protein phosphatase 14

1

1

High-throughput

0.489

High

334164

DLX6
Homeobox protein DLX-6

1

4

High-throughput

0.489

High

334176

TBL3
Transducin beta-like protein 3

1

1

High-throughput

0.489

High

334191

ANR39
Ankyrin repeat domain-containing protein 39

1

5

High-throughput

0.489

High

334213

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.489

High

334218

SHKB1
SH3KBP1-binding protein 1

1

5

High-throughput

0.489

High

334251

TF7L2
Transcription factor 7-like 2

1

1

High-throughput

0.489

High

295438

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

2

Small-scale

0.479

High

334137

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

334140

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

334147

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

2

High-throughput

0.479

High

334162

CASP9
Caspase-9

1

1

Small-scale

0.479

High

334172

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

334182

SQSTM
Sequestosome-1

1

1

Small-scale

0.479

High

334200

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

334214

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

334259

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

334260

HERC5
E3 ISG15--protein ligase HERC5

1

11

Small-scale

0.479

High

334262

APC7
Anaphase-promoting complex subunit 7

1

3

High-throughput

0.479

High

320602

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

334138

IL1B
Interleukin-1 beta

1

0

Small-scale

0.458

High

334144

LYN
Tyrosine-protein kinase Lyn

1

0

Small-scale

0.458

High

334146

HEM4
Uroporphyrinogen-III synthase

1

0

High-throughput

0.458

High

334165

GSDMD
Gasdermin-D

1

0

Small-scale

0.458

High

334227

VP13A
Intermembrane lipid transfer protein VPS13A

1

0

Small-scale

0.458

High

334244

RETR1
Reticulophagy regulator 1

1

0

Small-scale

0.458

High

334143

CAN1
Calpain-1 catalytic subunit

1

2

High-throughput

0.445

High

334161

PPP5
Serine/threonine-protein phosphatase 5

1

3

High-throughput

0.445

High

105017

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

259251

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.437

High

334221

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.437

High

334190

Q4KMX6
Anaphase-promoting complex subunit 7

1

3

High-throughput

0.407

High

334207

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.407

High

334198

K0930
Uncharacterized protein KIAA0930

4

0

High-throughput

0.360

High

334194

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

3

0

High-throughput

0.345

High

334261

RWD2A
RWD domain-containing protein 2A

3

0

High-throughput

0.345

High

334156

KCNJ5
G protein-activated inward rectifier potassium channel 4

2

0

High-throughput

0.328

High

168794

PLD2
Phospholipase D2

1

0

High-throughput

0.279

Low

334157

PRI1
DNA primase small subunit

1

0

High-throughput

0.279

Low

334158

PRI2
DNA primase large subunit

1

0

High-throughput

0.279

Low

334177

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

334193

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

1

0

High-throughput

0.279

Low

334195

F91A1
Protein FAM91A1

1

0

High-throughput

0.279

Low

334205

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.279

Low

334222

N42L2
NEDD4-binding protein 2-like 2

1

0

High-throughput

0.279

Low

334225

CC120
Coiled-coil domain-containing protein 120

1

0

High-throughput

0.279

Low

334238

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.279

Low

334245

ESRP2
Epithelial splicing regulatory protein 2

1

0

High-throughput

0.279

Low

334263

AT7L1
Ataxin-7-like protein 1

1

0

High-throughput

0.279

Low

334267

SALL2
Sal-like protein 2

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025