Protein: GSH0
Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit)

Gene: GSH0, GCLM
Organism: Homo sapiens
Interactions: 65
UniProt ID: P48507

Gene Ontology (top 5):
GO:0004357 - glutamate-cysteine ligase activity
GO:0005829 - cytosol
GO:0006534 - cysteine metabolic process
GO:0006536 - glutamate metabolic process
GO:0006750 - glutathione biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

873702

GSH1
Glutamate--cysteine ligase catalytic subunit

5

5

Small-scale

0.720

High

532149

HEM4
Uroporphyrinogen-III synthase

3

0

High-throughput

0.638

High

603204

KPCA
Protein kinase C alpha type

2

1

High-throughput

0.628

High

873752

PAR12
Protein mono-ADP-ribosyltransferase PARP12

2

1

High-throughput

0.574

High

642712

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.553

High

873747

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

563404

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

873741

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

873755

E41L5
Band 4.1-like protein 5

1

6

High-throughput

0.536

High

873739

STOX1
Storkhead-box protein 1

1

0

High-throughput

0.518

High

873745

IRF7
Interferon regulatory factor 7

1

0

High-throughput

0.518

High

873721

PCBP3
Poly(rC)-binding protein 3

1

1

High-throughput

0.515

High

873728

CUL3
Cullin-3

1

0

High-throughput

0.513

High

873759

RBX2
RING-box protein 2

1

0

High-throughput

0.513

High

873720

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

1

High-throughput

0.489

High

873751

SEM4C
Semaphorin-4C

1

2

High-throughput

0.489

High

400466

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

429505

JUN
Transcription factor Jun

1

1

Small-scale

0.479

High

659398

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

873719

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

1

High-throughput

0.479

High

873725

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

873731

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

873734

NF2L2
Nuclear factor erythroid 2-related factor 2

1

1

Small-scale

0.479

High

873746

OPTN
Optineurin

1

2

High-throughput

0.479

High

362957

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

830323

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

873726

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

873732

KS6A1
Ribosomal protein S6 kinase alpha-1

1

0

High-throughput

0.458

High

873748

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

873754

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

873760

TRM7
tRNA

1

0

High-throughput

0.458

High

839438

PI4KA
Phosphatidylinositol 4-kinase alpha

1

4

High-throughput

0.445

High

873736

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

873737

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.445

High

588165

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

694888

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

767662

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

873724

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

873729

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.437

High

873733

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

873735

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

4

High-throughput

0.437

High

873738

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

873740

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

873742

NIN
Ninein

1

1

High-throughput

0.437

High

873730

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

873743

GNPI2
Glucosamine-6-phosphate deaminase 2

1

0

High-throughput

0.426

High

66832

RFPLA
Ret finger protein-like 4A

1

1

High-throughput

0.407

High

774200

BASI
Basigin

1

1

High-throughput

0.407

High

873727

UPAR
Urokinase plasminogen activator surface receptor

2

0

High-throughput

0.318

High

873757

TRPV5
Transient receptor potential cation channel subfamily V member 5

2

0

High-throughput

0.318

High

873761

OSGI1
Oxidative stress-induced growth inhibitor 1

2

0

High-throughput

0.316

High

873756

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.279

Low

873764

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

418004

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

873718

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

873744

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.249

Low

873749

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

873750

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.249

Low

873753

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

873758

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

873762

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

873763

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.249

Low

584004

FOSL1
Fos-related antigen 1

1

0

High-throughput

0.232

Low

873722

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.232

Low

873723

NXPH1
Neurexophilin-1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025