Protein: DHB2
17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239)

Gene: DHB2, HSD17B2
Organism: Homo sapiens
Interactions: 12
UniProt ID: P37059

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0001890 - placenta development
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005789 - endoplasmic reticulum membrane
GO:0006703 - estrogen biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

788513

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

3

3

High-throughput

0.662

High

563338

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.541

High

788512

REEP6
Receptor expression-enhancing protein 6

1

2

High-throughput

0.536

High

788515

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

3

High-throughput

0.536

High

297163

PRAF3
PRA1 family protein 3

1

0

High-throughput

0.513

High

439670

INSR
Insulin receptor

1

4

High-throughput

0.489

High

788509

REEP5
Receptor expression-enhancing protein 5

1

2

High-throughput

0.489

High

612906

EGR1
Early growth response protein 1

1

1

High-throughput

0.437

High

788508

HNF4A
Hepatocyte nuclear factor 4-alpha

1

7

Small-scale

0.437

High

788511

MBNL2
Muscleblind-like protein 2

1

1

High-throughput

0.437

High

788510

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.279

Low

788514

TM109
Voltage-gated monoatomic cation channel TMEM109

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025