Protein: TM109
Voltage-gated monoatomic cation channel TMEM109 (Mitsugumin-23) (Mg23) (Transmembrane protein 109)

Gene: TM109, TMEM109
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q9BVC6

Gene Ontology (top 5):
GO:0005640 - nuclear outer membrane
GO:0022843 - voltage-gated monoatomic cation channel activity
GO:0033017 - sarcoplasmic reticulum membrane
GO:0034702 - monoatomic ion channel complex
GO:0042771 - intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211945

SPIT1
Kunitz-type protease inhibitor 1

2

1

High-throughput

0.606

High

690364

STOM
Stomatin

2

1

High-throughput

0.606

High

832650

AQP2
Aquaporin-2

2

0

High-throughput

0.580

High

1094870

PDZ1I
PDZK1-interacting protein 1

2

0

High-throughput

0.580

High

1195267

TM52B
Transmembrane protein 52B

2

0

High-throughput

0.580

High

213695

AQP9
Aquaporin-9

2

1

High-throughput

0.553

High

1393134

TMM80
Transmembrane protein 80

2

1

High-throughput

0.553

High

1415192

SAR1A
Small COPII coat GTPase SAR1A

2

1

High-throughput

0.553

High

423050

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.536

High

386176

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

1

High-throughput

0.535

High

384722

CRYAB
Alpha-crystallin B chain

1

0

Small-scale

0.529

High

956466

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.513

High

374171

RASN
GTPase NRas

1

2

High-throughput

0.479

High

466440

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.479

High

581261

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

766811

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

955539

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.479

High

962435

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

988668

RAC1
Ras-related C3 botulinum toxin substrate 1

1

5

High-throughput

0.479

High

1015730

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

174074

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

675140

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

715748

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

862421

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

895024

EMD
Emerin

1

0

High-throughput

0.458

High

901014

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.458

High

980255

H4
Histone H4

1

0

High-throughput

0.458

High

1115397

CUL4B
Cullin-4B

1

0

High-throughput

0.458

High

1291178

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

Small-scale

0.458

High

1413552

H2AJ
Histone H2A.J

1

0

High-throughput

0.458

High

1415182

TM109
Voltage-gated monoatomic cation channel TMEM109

1

0

High-throughput

0.458

High

126775

RHOD
Rho-related GTP-binding protein RhoD

1

6

High-throughput

0.437

High

375899

RASK
GTPase KRas

1

2

High-throughput

0.437

High

634607

LMNB1
Lamin-B1

1

1

High-throughput

0.437

High

1238803

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1287430

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

High-throughput

0.437

High

1294250

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.437

High

1334540

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.437

High

1392454

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1415187

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

1415197

TM216
Transmembrane protein 216

1

1

High-throughput

0.437

High

933470

S12A2
Solute carrier family 12 member 2

1

0

High-throughput

0.426

High

948927

CD81
CD81 antigen

1

0

High-throughput

0.426

High

663634

SC6A2
Sodium-dependent noradrenaline transporter

1

1

High-throughput

0.407

High

727574

SC6A4
Sodium-dependent serotonin transporter

1

1

High-throughput

0.407

High

944062

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

166994

MGST3
Glutathione S-transferase 3, mitochondrial

2

0

High-throughput

0.316

High

1053060

VMAT2
Synaptic vesicular amine transporter

2

0

High-throughput

0.316

High

1333488

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.316

High

1352510

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.316

High

1395620

RN170
E3 ubiquitin-protein ligase RNF170

2

0

High-throughput

0.316

High

1415186

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

1415200

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.316

High

417719

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

0

High-throughput

0.305

High

724171

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

788514

DHB2
17-beta-hydroxysteroid dehydrogenase type 2

1

0

High-throughput

0.279

Low

1212297

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.279

Low

1231462

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

1239042

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.279

Low

1326894

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

1382176

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.279

Low

1413688

TMM43
Transmembrane protein 43

1

0

High-throughput

0.279

Low

1415184

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1415194

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

1415202

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

181420

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.269

Low

106581

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

129387

MEN1
Menin

1

0

High-throughput

0.249

Low

134470

CCRL2
C-C chemokine receptor-like 2

1

0

High-throughput

0.249

Low

170325

AURKA
Aurora kinase A

1

0

High-throughput

0.249

Low

218712

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

349227

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.249

Low

418404

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

541665

FGFR1
Fibroblast growth factor receptor 1

1

0

Small-scale

0.249

Low

589579

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

635283

EFNA1
Ephrin-A1

1

0

High-throughput

0.249

Low

696391

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769060

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

820738

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.249

Low

831353

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

847669

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.249

Low

872695

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low

888299

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

904100

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.249

Low

951394

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.249

Low

1005047

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1031524

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.249

Low

1086303

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.249

Low

1088806

SEPR
Prolyl endopeptidase FAP

1

0

Small-scale

0.249

Low

1155718

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1249177

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1255345

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1289832

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

1322970

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1333981

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

1338346

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

1352724

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1367165

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

1379910

KISSR
KiSS-1 receptor

1

0

Small-scale

0.249

Low

1403407

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

1404180

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

1414436

DERL1
Derlin-1

1

0

High-throughput

0.249

Low

1415183

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.249

Low

1415185

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

1415188

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1415189

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

1415191

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

1415193

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1415195

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

1415196

GDE1
Glycerophosphodiester phosphodiesterase 1

1

0

High-throughput

0.249

Low

1415198

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low

1415199

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.249

Low

1415203

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

1415204

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.249

Low

230420

CREB3
Cyclic AMP-responsive element-binding protein 3

1

0

High-throughput

0.238

Low

66388

T238L
Transmembrane protein 238-like

1

0

Small-scale

0.232

Low

256133

S19A2
Thiamine transporter 1

1

0

High-throughput

0.232

Low

430309

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

1139556

S39AE
Metal cation symporter ZIP14

1

0

High-throughput

0.232

Low

1236299

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1336031

CTL5
Choline transporter-like protein 5

1

0

High-throughput

0.232

Low

1361299

CTR3
Cationic amino acid transporter 3

1

0

High-throughput

0.232

Low

1402846

DIRC2
Solute carrier family 49 member 4

1

0

High-throughput

0.232

Low

1415190

NCKX3
Sodium/potassium/calcium exchanger 3

1

0

High-throughput

0.232

Low

1415201

SHLB1
Endophilin-B1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025