Protein: SIZ2
E3 SUMO-protein ligase SIZ2 (EC 2.3.2.-) (E3 SUMO-protein transferase SIZ2) (SAP and Miz-finger domain-containing protein 2)

Gene: SIZ2, NFI1
Organism: Saccharomyces cerevisiae S288C
Interactions: 142
UniProt ID: Q12216

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003690 - double-stranded DNA binding
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

841451

UBC9
SUMO-conjugating enzyme UBC9

11

14

Small-scale

0.976

High

1015324

SMT3
Ubiquitin-like protein SMT3

5

20

Small-scale

0.895

High

550584

PCNA
Proliferating cell nuclear antigen

1

3

Small-scale

0.647

High

1015322

SIZ2
E3 SUMO-protein ligase SIZ2

1

9

Small-scale

0.647

High

523460

SRS2
ATP-dependent DNA helicase SRS2

2

3

Small-scale

0.614

High

676472

XPO1
Exportin-1

2

1

High-throughput

0.611

High

607359

RFA1
Replication factor A protein 1

2

1

Small-scale

0.595

High

765430

RSP5
E3 ubiquitin-protein ligase RSP5

2

3

Small-scale

0.595

High

767875

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

2

1

Small-scale

0.594

High

663656

TF2B
Transcription initiation factor IIB

2

1

High-throughput

0.584

High

977400

NSE5
Non-structural maintenance of chromosome element 5

2

1

Small-scale

0.576

High

698612

MRE11
Double-strand break repair protein MRE11

2

0

Small-scale

0.559

High

769789

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

797973

RSC8
Chromatin structure-remodeling complex protein RSC8

1

2

High-throughput

0.536

High

861548

RT102
Regulator of Ty1 transposition protein 102

1

1

High-throughput

0.536

High

644782

RFA2
Replication factor A protein 2

1

4

Small-scale

0.527

High

389752

CDC25
Cell division control protein 25

1

0

High-throughput

0.518

High

1015326

ARP7
Actin-related protein 7

1

3

High-throughput

0.515

High

988517

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.513

High

993150

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.513

High

706075

NIP80
Protein NIP100

1

2

High-throughput

0.508

High

419585

RAD1
DNA repair protein RAD1

1

2

Small-scale

0.501

High

698580

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

1

Small-scale

0.501

High

756336

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

1

2

Small-scale

0.501

High

764018

SAW1
Single-strand annealing weakened protein 1

1

1

Small-scale

0.501

High

764591

EXO1
Exodeoxyribonuclease 1

1

2

Small-scale

0.501

High

767114

YEN1
Holliday junction resolvase YEN1

1

2

Small-scale

0.501

High

858861

IMB5
Importin subunit beta-5

1

3

Small-scale

0.501

High

859698

LIF1
Ligase-interacting factor 1

1

1

Small-scale

0.501

High

995837

SGO1
Shugoshin

1

1

High-throughput

0.501

High

756240

LIN1
Protein LIN1

1

0

Small-scale

0.486

High

759207

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

High-throughput

0.486

High

690286

CDC3
Cell division control protein 3

1

1

Small-scale

0.481

High

454500

TBA1
Tubulin alpha-1 chain

1

1

Small-scale

0.481

High

454673

TBA3
Tubulin alpha-3 chain

1

1

Small-scale

0.481

High

514601

BIK1
Nuclear fusion protein BIK1

1

1

Small-scale

0.481

High

691671

NUP2
Nucleoporin NUP2

1

3

Small-scale

0.481

High

765491

LIS1
Nuclear distribution protein PAC1

1

2

Small-scale

0.481

High

774090

NDC80
Kinetochore protein NDC80

1

2

High-throughput

0.481

High

972030

ULP1
Ubiquitin-like-specific protease 1

1

2

Small-scale

0.481

High

977719

GIS1
Transcriptional activator/repressor GIS1

1

2

Small-scale

0.481

High

979623

EUC1
Transcription factor-like protein EUC1

1

1

Small-scale

0.481

High

1014937

ELG1
Telomere length regulation protein ELG1

1

5

Small-scale

0.481

High

420188

TOP2
DNA topoisomerase 2

1

4

High-throughput

0.479

High

520655

YPK1
Serine/threonine-protein kinase YPK1

1

4

High-throughput

0.479

High

523325

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

1

High-throughput

0.479

High

558323

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

593794

DBP5
ATP-dependent RNA helicase DBP5

1

4

High-throughput

0.479

High

627708

NAP1
Nucleosome assembly protein

1

1

High-throughput

0.479

High

636191

NOT1
General negative regulator of transcription subunit 1

1

1

High-throughput

0.479

High

687768

BTAF1
TATA-binding protein-associated factor MOT1

1

6

High-throughput

0.479

High

692968

SPT16
FACT complex subunit SPT16

1

2

High-throughput

0.479

High

732026

NNRD
ATP-dependent

1

1

High-throughput

0.479

High

751301

RFC3
Replication factor C subunit 3

1

2

High-throughput

0.479

High

751347

RFC1
Replication factor C subunit 1

1

4

High-throughput

0.479

High

763448

MET10
Sulfite reductase [NADPH] flavoprotein component

1

1

High-throughput

0.479

High

791212

EMW1
Essential for maintenance of the cell wall protein 1

1

1

High-throughput

0.479

High

797638

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

812031

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.479

High

859031

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.479

High

859288

INO80
Chromatin-remodeling ATPase INO80

1

6

High-throughput

0.479

High

961633

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

1

High-throughput

0.479

High

987856

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

8

High-throughput

0.479

High

988688

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

1

High-throughput

0.479

High

991964

ADY3
Accumulates dyads protein 3

1

4

High-throughput

0.479

High

1014860

MDN1
Midasin

1

6

High-throughput

0.479

High

1015325

ARP8
Actin-like protein ARP8

1

3

High-throughput

0.479

High

1015327

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

1015328

YB11B
Transposon Ty1-BL Gag-Pol polyprotein

1

1

High-throughput

0.479

High

690350

CDC11
Cell division control protein 11

1

3

High-throughput

0.464

High

811159

BBC1
Myosin tail region-interacting protein MTI1

1

2

High-throughput

0.464

High

361081

TBB
Tubulin beta chain

1

0

Small-scale

0.460

High

655770

PRP45
Pre-mRNA-processing protein 45

1

0

Small-scale

0.460

High

687557

DBF4
DDK kinase regulatory subunit DBF4

1

0

Small-scale

0.460

High

691940

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

Small-scale

0.460

High

692469

KAR9
Karyogamy protein KAR9

1

0

Small-scale

0.460

High

732526

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.460

High

978556

ECM11
Protein ECM11

1

0

Small-scale

0.460

High

979650

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.460

High

1015323

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.460

High

1015329

HUB1
Ubiquitin-like modifier HUB1

1

0

Small-scale

0.460

High

333996

ADH2
Alcohol dehydrogenase 2

1

0

High-throughput

0.458

High

342488

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.458

High

375538

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

434552

OAT
Ornithine aminotransferase

1

0

High-throughput

0.458

High

440118

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.458

High

516924

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.458

High

548567

GCN2
eIF-2-alpha kinase GCN2

1

0

High-throughput

0.458

High

586346

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

High-throughput

0.458

High

593354

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

630585

GFD2
Good for full DBP5 activity protein 2

1

0

High-throughput

0.458

High

657201

OPLA
5-oxoprolinase

1

0

High-throughput

0.458

High

691603

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.458

High

734049

NU133
Nucleoporin NUP133

1

0

High-throughput

0.458

High

745944

NU170
Nucleoporin NUP170

1

0

Small-scale

0.458

High

748325

SDS24
Protein SDS24

1

0

High-throughput

0.458

High

755506

SBE22
Protein SBE22

1

0

High-throughput

0.458

High

757164

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

0

High-throughput

0.458

High

766734

NUG1
Nuclear GTP-binding protein NUG1

1

0

High-throughput

0.458

High

793570

UAP1
UDP-N-acetylglucosamine pyrophosphorylase

1

0

High-throughput

0.458

High

814735

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.458

High

865891

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

High-throughput

0.458

High

975592

YM44
Uncharacterized protein YMR178W

1

0

High-throughput

0.458

High

976939

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.458

High

977872

DOP1
Protein dopey

1

0

High-throughput

0.458

High

978510

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.458

High

979866

POB3
FACT complex subunit POB3

1

0

High-throughput

0.458

High

980350

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.458

High

981831

YM94
Uncharacterized protein YMR315W

1

0

High-throughput

0.458

High

1014571

LKHA4
Leucine aminopeptidase 2

1

0

High-throughput

0.458

High

755266

IPI1
Pre-rRNA-processing protein IPI1

1

0

High-throughput

0.438

High

866197

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

425150

LEUC
3-isopropylmalate dehydratase

1

1

High-throughput

0.437

High

448527

PRTB
Cerevisin

1

1

High-throughput

0.437

High

578577

SEC18
Vesicular-fusion protein SEC18

1

1

High-throughput

0.437

High

630646

TRX3
Thioredoxin-3, mitochondrial

1

4

High-throughput

0.437

High

797734

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

1

High-throughput

0.437

High

798127

COPD
Coatomer subunit delta

1

1

High-throughput

0.437

High

860081

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

1

High-throughput

0.437

High

977145

ESC1
Silent chromatin protein ESC1

1

1

Small-scale

0.437

High

978427

YHM2
Citrate/oxoglutarate carrier protein

1

1

High-throughput

0.437

High

544592

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.426

High

773880

BNR1
BNI1-related protein 1

1

1

High-throughput

0.417

High

731893

EBP2
rRNA-processing protein EBP2

1

0

Small-scale

0.288

High

766779

BIM1
Protein BIM1

1

0

Small-scale

0.251

Low

805175

STU2
Protein STU2

1

0

Small-scale

0.251

Low

410194

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.249

Low

450524

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.249

Low

534413

DPM1
Dolichol-phosphate mannosyltransferase

1

0

High-throughput

0.249

Low

567489

KHSE
Homoserine kinase

1

0

High-throughput

0.249

Low

669547

ERG9
Squalene synthase ERG9

1

0

High-throughput

0.249

Low

686236

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

696836

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.249

Low

731024

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.249

Low

744346

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

0

High-throughput

0.249

Low

751436

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.249

Low

767986

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

Small-scale

0.249

Low

796951

GCN20
Protein GCN20

1

0

High-throughput

0.249

Low

985318

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

High-throughput

0.249

Low

777353

HACD
Very-long-chain

1

0

High-throughput

0.238

Low

811624

GPI14
GPI mannosyltransferase 1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024