Protein: SYNE4
Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4)

Gene: SYNE4
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q8N205

Gene Ontology (top 5):
GO:0005640 - nuclear outer membrane
GO:0034993 - meiotic nuclear membrane microtubule tethering complex
GO:0045198 - establishment of epithelial cell apical/basal polarity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1323900

SUN2
SUN domain-containing protein 2

2

1

Small-scale

0.819

High

321004

SUN1
SUN domain-containing protein 1

1

1

Small-scale

0.716

High

1323867

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

5

1

High-throughput

0.660

High

1323892

KLC4
Kinesin light chain 4

4

7

High-throughput

0.644

High

1155007

ADIPO
Adiponectin

4

1

High-throughput

0.639

High

244175

KIF5C
Kinesin heavy chain isoform 5C

3

2

High-throughput

0.609

High

247526

FZD6
Frizzled-6

3

2

High-throughput

0.609

High

749964

KINH
Kinesin-1 heavy chain

3

2

High-throughput

0.609

High

1060544

KLC1
Kinesin light chain 1

3

8

High-throughput

0.609

High

1087015

KIF5A
Kinesin heavy chain isoform 5A

3

2

High-throughput

0.609

High

1157373

EXT1
Exostosin-1

3

1

High-throughput

0.609

High

1242675

KLC3
Kinesin light chain 3

3

7

High-throughput

0.609

High

1323883

KLC2
Kinesin light chain 2

3

7

High-throughput

0.609

High

1323887

FZD3
Frizzled-3

3

2

High-throughput

0.609

High

1323906

MAN1
Inner nuclear membrane protein Man1

3

1

High-throughput

0.609

High

1121455

KEAP1
Kelch-like ECH-associated protein 1

2

1

High-throughput

0.558

High

1125860

FZD2
Frizzled-2

2

2

High-throughput

0.558

High

1213232

ZN648
Zinc finger protein 648

2

1

High-throughput

0.553

High

1323866

CLD19
Claudin-19

2

2

High-throughput

0.553

High

337893

CLD7
Claudin-7

1

2

High-throughput

0.523

High

942281

CLD8
Claudin-8

1

2

High-throughput

0.523

High

1199001

KLH12
Kelch-like protein 12

1

1

High-throughput

0.523

High

1323877

KLRG1
Killer cell lectin-like receptor subfamily G member 1

1

1

High-throughput

0.523

High

69662

A8K660
Adiponectin

1

1

High-throughput

0.470

High

230819

EXTL3
Exostosin-like 3

1

1

High-throughput

0.437

High

1323868

LEMD2
LEM domain-containing protein 2

1

1

High-throughput

0.437

High

1252124

SYNE3
Nesprin-3

1

0

Small-scale

0.426

High

3484

A0A0S2Z5K4
Hexosyltransferase

1

1

High-throughput

0.417

High

1159748

OCLN
Occludin

4

0

High-throughput

0.368

High

1092786

MALL
MAL-like protein

3

0

High-throughput

0.352

High

1323880

CEP19
Centrosomal protein of 19 kDa

3

0

High-throughput

0.352

High

1323889

SMCO4
Single-pass membrane and coiled-coil domain-containing protein 4

3

0

High-throughput

0.352

High

136518

GOLI4
Golgi integral membrane protein 4

3

0

High-throughput

0.347

High

213330

ADCY6
Adenylate cyclase type 6

3

0

High-throughput

0.347

High

226439

SNG2
Synaptogyrin-2

3

0

High-throughput

0.347

High

295752

AP1G2
AP-1 complex subunit gamma-like 2

3

0

High-throughput

0.347

High

327354

ZFPL1
Zinc finger protein-like 1

3

0

High-throughput

0.347

High

334054

SMC2
Structural maintenance of chromosomes protein 2

3

0

High-throughput

0.347

High

841214

CNDD3
Condensin-2 complex subunit D3

3

0

High-throughput

0.347

High

1106168

TUSC3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3

3

0

High-throughput

0.347

High

1233760

CNDH2
Condensin-2 complex subunit H2

3

0

High-throughput

0.347

High

1293259

LSR
Lipolysis-stimulated lipoprotein receptor

3

0

High-throughput

0.347

High

1323873

SARAF
Store-operated calcium entry-associated regulatory factor

3

0

High-throughput

0.347

High

1323879

B3GT6
Beta-1,3-galactosyltransferase 6

3

0

High-throughput

0.347

High

1323884

TM231
Transmembrane protein 231

3

0

High-throughput

0.347

High

1323885

FKRP
Ribitol 5-phosphate transferase FKRP

3

0

High-throughput

0.347

High

1323888

GPC5C
G-protein coupled receptor family C group 5 member C

3

0

High-throughput

0.347

High

1323903

DSE
Dermatan-sulfate epimerase

3

0

High-throughput

0.347

High

1323907

ZDHC9
Palmitoyltransferase ZDHHC9

3

0

High-throughput

0.347

High

548058

PSPC
Surfactant protein C

2

0

High-throughput

0.343

High

1323882

CLC7A
C-type lectin domain family 7 member A

2

0

High-throughput

0.334

High

1323891

SERC1
Serine incorporator 1

2

0

High-throughput

0.328

High

1323899

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.327

High

1323870

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.318

High

665998

IBP5
Insulin-like growth factor-binding protein 5

2

0

High-throughput

0.316

High

1150127

TCEA2
Transcription elongation factor A protein 2

2

0

High-throughput

0.316

High

1313618

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

2

0

High-throughput

0.316

High

142651

SARCO
Sarcolipin

1

0

High-throughput

0.299

High

277055

ENTP3
Ectonucleoside triphosphate diphosphohydrolase 3

1

0

High-throughput

0.299

High

349479

TSN15
Tetraspanin-15

1

0

High-throughput

0.299

High

585067

ZN250
Zinc finger protein 250

1

0

High-throughput

0.299

High

932696

EMP1
Epithelial membrane protein 1

1

0

High-throughput

0.299

High

942382

EP3B
Epididymal secretory protein E3-beta

1

0

High-throughput

0.299

High

1059081

CXCL9
C-X-C motif chemokine 9

1

0

High-throughput

0.299

High

1064718

CD47
Leukocyte surface antigen CD47

1

0

High-throughput

0.299

High

1089151

TM115
Transmembrane protein 115

1

0

High-throughput

0.299

High

1148997

SC23B
Protein transport protein Sec23B

1

0

High-throughput

0.299

High

1203720

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.299

High

1205421

DB121
Beta-defensin 121

1

0

High-throughput

0.299

High

1215241

RIPP2
Protein ripply2

1

0

High-throughput

0.299

High

1245878

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.299

High

1249414

OLFM4
Olfactomedin-4

1

0

High-throughput

0.299

High

1253278

TM182
Transmembrane protein 182

1

0

High-throughput

0.299

High

1288725

KTN1
Kinectin

1

0

High-throughput

0.299

High

1292724

TRI69
E3 ubiquitin-protein ligase TRIM69

1

0

High-throughput

0.299

High

1323872

FATE1
Fetal and adult testis-expressed transcript protein

1

0

High-throughput

0.299

High

1323875

F241B
Protein FAM241B

1

0

High-throughput

0.299

High

1323876

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.299

High

1323878

SC22A
Vesicle-trafficking protein SEC22a

1

0

High-throughput

0.299

High

1323881

TM147
BOS complex subunit TMEM147

1

0

High-throughput

0.299

High

1323886

SENP2
Sentrin-specific protease 2

1

0

High-throughput

0.299

High

1323890

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.299

High

1323893

TM140
Transmembrane protein 140

1

0

High-throughput

0.299

High

1323896

TM248
Transmembrane protein 248

1

0

High-throughput

0.299

High

1323897

PAQR5
Membrane progestin receptor gamma

1

0

High-throughput

0.299

High

1323898

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

0

High-throughput

0.299

High

1323904

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.299

High

1323905

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.299

High

564046

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.282

High

1323871

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.279

Low

516911

EFCE2
EEF1AKMT4-ECE2 readthrough transcript protein

1

0

High-throughput

0.268

Low

1323869

Q8TBU1
Oligosaccharyltransferase complex subunit

1

0

High-throughput

0.268

Low

1323874

OPTN
Optineurin

1

0

High-throughput

0.268

Low

665273

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.265

Low

891672

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.265

Low

995131

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.265

Low

1323901

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.265

Low

1323902

KS6A6
Ribosomal protein S6 kinase alpha-6

1

0

High-throughput

0.265

Low

270024

XYLK
Glycosaminoglycan xylosylkinase

1

0

High-throughput

0.249

Low

333091

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

0

High-throughput

0.249

Low

1257523

TMTC3
Protein O-mannosyl-transferase TMTC3

1

0

High-throughput

0.249

Low

1314511

TM192
Transmembrane protein 192

1

0

High-throughput

0.249

Low

1323894

TM39A
Transmembrane protein 39A

1

0

High-throughput

0.249

Low

1323895

DJC11
DnaJ homolog subfamily C member 11

1

0

High-throughput

0.249

Low

1323908

POMT1
Protein O-mannosyl-transferase 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025