Protein: DPOE
DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A)

Gene: DPOE, POL2
Organism: Saccharomyces cerevisiae S288C
Interactions: 113
UniProt ID: P21951

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000278 - mitotic cell cycle
GO:0003677 - DNA binding
GO:0003690 - double-stranded DNA binding
GO:0003697 - single-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

602310

DPB2
DNA polymerase epsilon subunit B

25

4

Small-scale

0.991

High

526817

DPOLA
DNA polymerase alpha catalytic subunit A

3

2

Small-scale

0.857

High

593798

PRI2
DNA primase large subunit

3

3

Small-scale

0.857

High

602377

DPB4
DNA polymerase epsilon subunit D

16

2

Small-scale

0.762

High

602363

CTF18
Chromosome transmission fidelity protein 18

6

3

Small-scale

0.740

High

602313

DCC1
Sister chromatid cohesion protein DCC1

2

0

Small-scale

0.728

High

602315

DPB3
DNA polymerase epsilon subunit C

16

0

Small-scale

0.728

High

602374

SLD5
DNA replication complex GINS protein SLD5

5

7

Small-scale

0.702

High

602323

MCM4
DNA replication licensing factor MCM4

4

12

Small-scale

0.680

High

488480

PRI1
DNA primase small subunit

3

4

Small-scale

0.674

High

602321

MCM2
DNA replication licensing factor MCM2

3

10

Small-scale

0.656

High

602309

MCM3
DNA replication licensing factor MCM3

3

10

Small-scale

0.646

High

355777

H2B2
Histone H2B.2

3

6

Small-scale

0.643

High

602360

DPB11
DNA replication regulator DPB11

3

1

Small-scale

0.642

High

602382

CDC45
Cell division control protein 45

3

4

Small-scale

0.641

High

602303

DPOE
DNA polymerase epsilon catalytic subunit A

1

3

Small-scale

0.621

High

602314

MRC1
Mediator of replication checkpoint protein 1

2

0

Small-scale

0.605

High

424812

IF4E
Eukaryotic translation initiation factor 4E

2

0

High-throughput

0.602

High

602350

IF4F1
Eukaryotic initiation factor 4F subunit p150

2

0

High-throughput

0.595

High

602322

MCM5
Minichromosome maintenance protein 5

2

10

Small-scale

0.585

High

602325

SPT16
FACT complex subunit SPT16

2

1

Small-scale

0.584

High

602334

SLD2
DNA replication regulator SLD2

2

0

Small-scale

0.569

High

602326

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

2

0

High-throughput

0.563

High

602345

RT107
Regulator of Ty1 transposition protein 107

1

2

Small-scale

0.552

High

602361

TRF5
Poly(A) RNA polymerase protein 1

1

1

Small-scale

0.552

High

602367

PAP2
Poly(A) RNA polymerase protein 2

1

1

Small-scale

0.552

High

490340

HSP71
Heat shock protein SSA1

2

8

High-throughput

0.552

High

510261

SSB1
Ribosome-associated molecular chaperone SSB1

2

10

High-throughput

0.552

High

602353

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.552

High

602340

NSE2
E3 SUMO-protein ligase MMS21

1

0

Small-scale

0.537

High

602318

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

2

1

High-throughput

0.537

High

392292

H2A2
Histone H2A.2

1

1

High-throughput

0.536

High

549951

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.536

High

334434

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.515

High

602328

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.513

High

602332

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.513

High

339436

CDK1
Cyclin-dependent kinase 1

1

5

Small-scale

0.501

High

565453

PHO85
Cyclin-dependent protein kinase PHO85

1

5

Small-scale

0.501

High

602304

RAD53
Serine/threonine-protein kinase RAD53

1

2

Small-scale

0.501

High

602306

KC12
Casein kinase I homolog 2

1

2

Small-scale

0.501

High

602307

BUR1
Serine/threonine-protein kinase BUR1

1

5

Small-scale

0.501

High

602320

HRR25
Casein kinase I homolog HRR25

1

1

Small-scale

0.501

High

602337

MCM7
DNA replication licensing factor MCM7

1

7

Small-scale

0.501

High

602338

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

3

Small-scale

0.501

High

602351

KC13
Casein kinase I homolog 3

1

2

Small-scale

0.501

High

602355

PSF2
DNA replication complex GINS protein PSF2

1

1

Small-scale

0.501

High

602364

MCM6
DNA replication licensing factor MCM6

1

10

Small-scale

0.501

High

602385

PSF3
DNA replication complex GINS protein PSF3

1

1

Small-scale

0.501

High

602388

PSF1
DNA replication complex GINS protein PSF1

1

2

Small-scale

0.501

High

602341

INM1
Inositol monophosphatase 1

1

0

High-throughput

0.493

High

602346

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

543198

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.489

High

602331

SMC1
Structural maintenance of chromosomes protein 1

1

2

Small-scale

0.481

High

602387

SMT3
Ubiquitin-like protein SMT3

1

2

Small-scale

0.481

High

602379

RT103
Regulator of Ty1 transposition protein 103

1

0

Small-scale

0.480

High

355347

H2B1
Histone H2B.1

1

6

Small-scale

0.479

High

406785

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

557874

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

597786

PWP1
Periodic tryptophan protein 1

1

2

High-throughput

0.479

High

602317

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

602319

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

602324

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

602336

GBLP
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.479

High

602339

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.479

High

602342

RRM3
ATP-dependent DNA helicase RRM3

1

2

Small-scale

0.479

High

602344

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

2

Small-scale

0.479

High

602357

MPH1
ATP-dependent DNA helicase MPH1

1

2

High-throughput

0.479

High

602358

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

602365

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.479

High

602368

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

602369

H3
Histone H3

1

7

Small-scale

0.479

High

602371

SEN1
Helicase SEN1

1

2

Small-scale

0.479

High

602373

CTF4
DNA polymerase alpha-binding protein

1

7

Small-scale

0.479

High

602375

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

602378

POB3
FACT complex subunit POB3

1

3

Small-scale

0.479

High

602383

SMC5
Structural maintenance of chromosomes protein 5

1

3

Small-scale

0.479

High

602386

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.479

High

577286

GLN3
Nitrogen regulatory protein GLN3

1

0

High-throughput

0.458

High

602308

SPT6
Transcription elongation factor SPT6

1

0

Small-scale

0.458

High

602329

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

602335

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

602356

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

602376

SIZ1
E3 SUMO-protein ligase SIZ1

1

0

High-throughput

0.458

High

602305

KCC2
Calcium/calmodulin-dependent protein kinase II

1

1

Small-scale

0.457

High

602316

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

Small-scale

0.457

High

493201

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

602312

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

602327

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.445

High

602343

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

602347

CAJ1
Protein CAJ1

1

4

High-throughput

0.445

High

602354

RAD26
DNA repair and recombination protein RAD26

1

3

Small-scale

0.445

High

407727

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

602311

BPH1
Beige protein homolog 1

1

1

High-throughput

0.437

High

602348

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

602370

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

602381

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

477900

HSP77
Import motor subunit, mitochondrial

1

6

High-throughput

0.407

High

555810

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

602333

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.407

High

602352

HSP7E
Heat shock protein SSC3, mitochondrial

1

6

High-throughput

0.407

High

602380

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

5

High-throughput

0.407

High

602349

SLN1
Osmosensing histidine protein kinase SLN1

1

0

Small-scale

0.261

Low

602366

SSK2
MAP kinase kinase kinase SSK2

1

0

Small-scale

0.261

Low

405431

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

481282

RL2A
Large ribosomal subunit protein uL2A

1

0

High-throughput

0.249

Low

534885

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.249

Low

602330

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

602362

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

602384

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

367741

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

602359

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

602372

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024