Protein: PTN5
Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP)

Gene: PTN5, PTPN5
Organism: Homo sapiens
Interactions: 79
UniProt ID: P54829

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0004725 - protein tyrosine phosphatase activity
GO:0005654 - nucleoplasm
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

691687

MK03
Mitogen-activated protein kinase 3

5

20

Small-scale

0.720

High

703513

MK01
Mitogen-activated protein kinase 1

5

20

Small-scale

0.720

High

869828

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

3

1

High-throughput

0.656

High

932571

MK14
Mitogen-activated protein kinase 14

3

20

High-throughput

0.656

High

932598

MOB1A
MOB kinase activator 1A

2

6

High-throughput

0.646

High

932608

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

1

High-throughput

0.628

High

440463

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

932562

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

18

High-throughput

0.618

High

443731

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

2

1

High-throughput

0.611

High

932600

RTN4
Reticulon-4

2

2

High-throughput

0.611

High

932579

CLC4G
C-type lectin domain family 4 member G

2

8

High-throughput

0.606

High

665559

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

2

0

High-throughput

0.585

High

932596

GHITM
Growth hormone-inducible transmembrane protein

2

0

High-throughput

0.585

High

932605

VAPA
Vesicle-associated membrane protein-associated protein A

2

2

High-throughput

0.584

High

156552

C56D2
Transmembrane reductase CYB561D2

2

0

High-throughput

0.580

High

277051

ENTP3
Ectonucleoside triphosphate diphosphohydrolase 3

2

0

High-throughput

0.580

High

932566

S35B1
Solute carrier family 35 member B1

2

0

High-throughput

0.580

High

932602

MARH5
E3 ubiquitin-protein ligase MARCHF5

2

0

High-throughput

0.580

High

932601

TMM51
Transmembrane protein 51

1

2

High-throughput

0.573

High

241201

PRKN
E3 ubiquitin-protein ligase parkin

1

3

Small-scale

0.561

High

932578

S27A4
Long-chain fatty acid transport protein 4

2

0

High-throughput

0.559

High

932599

S61A2
Protein transport protein Sec61 subunit alpha isoform 2

2

3

High-throughput

0.558

High

928391

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.549

High

932568

CXCL9
C-X-C motif chemokine 9

1

0

High-throughput

0.549

High

329829

SNX4
Sorting nexin-4

1

1

High-throughput

0.541

High

932589

CUL5
Cullin-5

1

4

High-throughput

0.541

High

130050

PGRC1
Membrane-associated progesterone receptor component 1

1

4

High-throughput

0.536

High

317996

TOM70
Mitochondrial import receptor subunit TOM70

1

4

High-throughput

0.536

High

409327

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

5

High-throughput

0.536

High

418038

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.536

High

932576

A20A1
Ankyrin repeat domain-containing protein 20A1

1

9

High-throughput

0.536

High

932577

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

3

High-throughput

0.536

High

932582

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.536

High

932586

MSPD2
Motile sperm domain-containing protein 2

1

3

High-throughput

0.536

High

932587

DCAKD
Dephospho-CoA kinase domain-containing protein

1

1

High-throughput

0.536

High

932591

CERS2
Ceramide synthase 2

1

6

High-throughput

0.536

High

932595

DUS15
Dual specificity protein phosphatase 15

1

4

High-throughput

0.536

High

932597

REEP4
Receptor expression-enhancing protein 4

1

2

High-throughput

0.536

High

932593

Q9BSA0
TMEM51 protein

1

2

High-throughput

0.515

High

387253

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.513

High

417342

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.513

High

784558

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.513

High

932567

MEF2A
Myocyte-specific enhancer factor 2A

1

0

High-throughput

0.513

High

932573

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.513

High

932574

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.513

High

932588

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

0

High-throughput

0.513

High

932603

UBIP1
Upstream-binding protein 1

1

0

High-throughput

0.513

High

932606

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

176392

ZBTB5
Zinc finger and BTB domain-containing protein 5

1

2

High-throughput

0.494

High

932583

CCNQ
Cyclin-Q

1

1

High-throughput

0.494

High

932581

ZN547
Zinc finger protein 547

1

1

High-throughput

0.489

High

170029

AURKA
Aurora kinase A

1

4

High-throughput

0.479

High

332937

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

2

High-throughput

0.479

High

507728

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.479

High

827153

ARL1
ADP-ribosylation factor-like protein 1

1

4

High-throughput

0.479

High

911971

DGKE
Diacylglycerol kinase epsilon

1

1

High-throughput

0.479

High

932563

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

3

High-throughput

0.479

High

932564

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

1

High-throughput

0.479

High

932565

DLG4
Disks large homolog 4

1

9

Small-scale

0.479

High

932570

MK11
Mitogen-activated protein kinase 11

1

20

High-throughput

0.479

High

932572

MAPK3
MAP kinase-activated protein kinase 3

1

7

High-throughput

0.479

High

932580

5MP2
eIF5-mimic protein 2

1

2

High-throughput

0.479

High

932609

TBL2
Transducin beta-like protein 2

1

2

High-throughput

0.479

High

184978

SPTC2
Serine palmitoyltransferase 2

1

0

High-throughput

0.458

High

932569

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.458

High

932594

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

0

High-throughput

0.458

High

932604

HACD3
Very-long-chain

1

0

High-throughput

0.458

High

932607

DHCR7
7-dehydrocholesterol reductase

1

0

High-throughput

0.458

High

932610

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.458

High

529420

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

932584

TXND5
Thioredoxin domain-containing protein 5

1

15

High-throughput

0.437

High

932585

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

3

High-throughput

0.437

High

298690

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

2

0

High-throughput

0.318

High

932575

TM201
Transmembrane protein 201

2

0

High-throughput

0.316

High

932590

FAF2
FAS-associated factor 2

2

0

High-throughput

0.305

High

256527

TBX19
T-box transcription factor TBX19

1

0

High-throughput

0.279

Low

431397

AT5G1
ATP synthase F(0) complex subunit C1, mitochondrial

1

0

High-throughput

0.279

Low

932592

A7L3B
Ataxin-7-like protein 3B

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025