Protein: MPS1
Serine/threonine-protein kinase MPS1 (EC 2.7.12.2) (Monopolar spindle protein 1) (Regulatory cell proliferation kinase 1)

Gene: MPS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 85
UniProt ID: P54199

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

867912

MPS1
Serine/threonine-protein kinase MPS1

5

18

Small-scale

0.916

High

416800

CDC31
Cell division control protein 31

3

9

Small-scale

0.853

High

774067

NDC80
Kinetochore protein NDC80

7

20

Small-scale

0.751

High

366717

HSP82
ATP-dependent molecular chaperone HSP82

1

20

High-throughput

0.724

High

708037

NUF2
Kinetochore protein NUF2

5

5

Small-scale

0.713

High

664521

HRR25
Casein kinase I homolog HRR25

1

17

High-throughput

0.691

High

867918

SPC24
Kinetochore protein SPC24

4

1

Small-scale

0.689

High

798058

CENPT
Inner kinetochore subunit CNN1

5

0

Small-scale

0.681

High

859667

SP105
Spindle pole body component SPC105

4

0

Small-scale

0.667

High

689284

SP110
Spindle pole body component 110

3

20

Small-scale

0.664

High

409913

CDC37
Hsp90 co-chaperone Cdc37

1

12

Small-scale

0.656

High

774487

MOB1
DBF2 kinase activator protein MOB1

2

3

Small-scale

0.649

High

628345

SIS1
Protein SIS1

1

11

High-throughput

0.647

High

649913

CDC15
Cell division control protein 15

1

17

High-throughput

0.647

High

750941

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

20

High-throughput

0.647

High

783853

BUB1
Checkpoint serine/threonine-protein kinase BUB1

1

19

Small-scale

0.647

High

866236

DMA2
E3 ubiquitin-protein ligase DMA2

1

2

High-throughput

0.647

High

867923

PML1
Pre-mRNA leakage protein 1

1

2

High-throughput

0.647

High

732510

SPC42
Spindle pole body component SPC42

2

1

Small-scale

0.639

High

775810

DSN1
Kinetochore-associated protein DSN1

3

0

Small-scale

0.628

High

867926

SGO1
Shugoshin

2

1

Small-scale

0.624

High

420320

CALM
Calmodulin

1

5

High-throughput

0.618

High

687887

NUD1
Protein NUD1

1

16

High-throughput

0.618

High

859567

MLC1
Myosin light chain 1

1

3

High-throughput

0.618

High

693144

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

18

Small-scale

0.618

High

867928

NBP2
NAP1-binding protein 2

2

1

High-throughput

0.614

High

705949

SPC29
Spindle pole component 29

2

0

Small-scale

0.592

High

766815

SPC25
Kinetochore protein SPC25

2

0

Small-scale

0.592

High

666272

BEM1
Bud emergence protein 1

2

9

High-throughput

0.586

High

763698

MBO1
Gamma tubulin complex adapter SPC72

2

1

Small-scale

0.585

High

492098

HSP71
Heat shock protein SSA1

2

19

High-throughput

0.571

High

697982

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

2

High-throughput

0.568

High

419628

RAD52
DNA repair and recombination protein RAD52

1

2

Small-scale

0.561

High

810672

ALY2
Arrestin-related trafficking adapter 3

2

5

High-throughput

0.550

High

716102

CENPC
Inner kinetochore subunit MIF2

1

1

High-throughput

0.536

High

734159

ESL2
EST/SMG-like protein 2

1

1

High-throughput

0.536

High

748296

CENPU
Inner kinetochore subunit AME1

1

1

High-throughput

0.536

High

811851

BFA1
Mitotic check point protein BFA1

1

1

High-throughput

0.536

High

867927

NSL1
Kinetochore-associated protein NSL1

1

1

High-throughput

0.536

High

867930

SFI1
Protein SFI1

1

1

High-throughput

0.536

High

692591

ZUO1
Zuotin

1

9

High-throughput

0.514

High

763947

MTW1
Kinetochore-associated protein MTW1

1

0

High-throughput

0.513

High

812422

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.513

High

861312

CENPQ
Inner kinetochore subunit OKP1

1

0

High-throughput

0.513

High

867915

RPM2
Ribonuclease P protein component, mitochondrial

1

0

High-throughput

0.513

High

867932

NKP1
Inner kinetochore subunit NKP1

1

0

High-throughput

0.513

High

867933

CENPI
Inner kinetochore subunit CTF3

1

0

High-throughput

0.513

High

356644

H4
Histone H4

1

6

Small-scale

0.501

High

766767

BIM1
Protein BIM1

1

4

Small-scale

0.501

High

773970

MLP2
Protein MLP2

1

20

Small-scale

0.501

High

778468

MAD1
Spindle assembly checkpoint component MAD1

1

20

Small-scale

0.501

High

797985

IRC5
Uncharacterized ATP-dependent helicase IRC5

1

2

High-throughput

0.501

High

809652

SIP4
Protein SIP4

1

2

High-throughput

0.501

High

865601

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

10

High-throughput

0.501

High

867925

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

1

High-throughput

0.501

High

691755

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

3

High-throughput

0.489

High

773924

ESL1
EST/SMG-like protein 1

1

1

High-throughput

0.489

High

589005

HOP1
Meiosis-specific protein HOP1

1

0

High-throughput

0.480

High

867917

YM04
Abasic site processing protein YMR114C

1

0

High-throughput

0.480

High

860049

CDH1
APC/C activator protein CDH1

1

20

Small-scale

0.479

High

867931

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.460

High

710497

YBF5
Deoxyribonuclease Tat-D

1

1

High-throughput

0.457

High

746024

ATG8
Autophagy-related protein 8

1

2

High-throughput

0.457

High

757120

CRG1
Probable S-adenosylmethionine-dependent methyltransferase CRG1

1

1

High-throughput

0.457

High

859847

DUO1
DASH complex subunit DUO1

1

1

Small-scale

0.457

High

867919

AIM33
Uncharacterized oxidoreductase AIM33

1

7

High-throughput

0.457

High

867920

YM11A
Transposon Ty1-ML1 Gag polyprotein

1

6

High-throughput

0.457

High

867921

RGC1
Regulator of the glycerol channel 1

1

3

High-throughput

0.457

High

867922

ACK1
Activator of C kinase protein 1

1

3

High-throughput

0.457

High

867929

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

4

High-throughput

0.457

High

867914

UBC7
Ubiquitin-conjugating enzyme E2 7

1

4

High-throughput

0.457

High

867916

MYO5
Myosin-5

1

20

High-throughput

0.457

High

494684

HSP72
Heat shock protein SSA2

1

19

High-throughput

0.445

High

512322

SSB1
Ribosome-associated molecular chaperone SSB1

1

18

High-throughput

0.445

High

554716

HSP26
Heat shock protein 26

1

2

High-throughput

0.445

High

769153

SSB2
Ribosome-associated molecular chaperone SSB2

1

18

High-throughput

0.445

High

867924

NBA1
Protein NBA1

1

2

High-throughput

0.437

High

860953

DAM1
DASH complex subunit DAM1

4

0

Small-scale

0.357

High

728370

ASK1
DASH complex subunit ASK1

1

0

Small-scale

0.261

Low

732645

YKC3
Uncharacterized protein YKL023W

1

0

High-throughput

0.261

Low

784933

PTE1
Peroxisomal acyl-coenzyme A thioester hydrolase 1

1

0

High-throughput

0.261

Low

867913

SPR6
Sporulation-specific protein

1

0

High-throughput

0.251

Low

867934

AIM44
Altered inheritance of mitochondria protein 44

1

0

High-throughput

0.249

Low

865898

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024