Protein: DIG1
Down-regulator of invasive growth 1 (Regulator of STE12 protein 1) (Regulator of sterile twelve 1)

Gene: DIG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 122
UniProt ID: Q03063

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0010570 - regulation of filamentous growth
GO:0045894 - negative regulation of mating-type specific transcription, DNA-templated

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

574732

KSS1
Mitogen-activated protein kinase KSS1

8

2

Small-scale

0.755

High

599393

FUS3
Mitogen-activated protein kinase FUS3

6

1

Small-scale

0.742

High

564672

STE12
Protein STE12

12

0

Small-scale

0.728

High

1040659

DIG2
Down-regulator of invasive growth 2

6

0

Small-scale

0.697

High

524945

HSP71
Heat shock protein SSA1

4

1

High-throughput

0.666

High

613829

TEC1
Ty transcription activator TEC1

3

0

Small-scale

0.645

High

393221

HSP82
ATP-dependent molecular chaperone HSP82

3

1

High-throughput

0.640

High

1039017

IMA1
Importin subunit alpha

2

0

High-throughput

0.565

High

919428

PBP1
PAB1-binding protein 1

2

0

Small-scale

0.561

High

527514

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.552

High

546024

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

778966

KDX1
Serine/threonine-protein kinase KDX1

1

2

High-throughput

0.536

High

781725

SA190
SIT4-associating protein SAP190

1

1

High-throughput

0.536

High

828506

SA185
SIT4-associating protein SAP185

1

1

High-throughput

0.536

High

1027264

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

3

High-throughput

0.536

High

416910

CDC25
Cell division control protein 25

1

0

High-throughput

0.518

High

694240

BUD14
Bud site selection protein 14

1

0

High-throughput

0.518

High

454480

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

633503

PP11
Serine/threonine-protein phosphatase PP1-1

1

0

High-throughput

0.513

High

722204

XPO1
Exportin-1

1

0

High-throughput

0.513

High

1040658

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.513

High

1040675

SUS1
SAGA complex subunit SUS1

1

0

High-throughput

0.513

High

602613

PHO85
Cyclin-dependent protein kinase PHO85

1

1

High-throughput

0.508

High

632396

CG11
G1/S-specific cyclin CLN1

1

1

Small-scale

0.508

High

632436

CG12
G1/S-specific cyclin CLN2

1

1

Small-scale

0.508

High

792439

BOI1
BEM1-interacting protein 1

1

1

High-throughput

0.494

High

816044

BOI2
BEM1-interacting protein 2

1

1

High-throughput

0.494

High

515397

MTAL1
Mating-type protein ALPHA1

1

0

High-throughput

0.486

High

628088

FKBP
FK506-binding protein 1

1

0

High-throughput

0.486

High

805628

LSM12
Protein LSM12

1

0

High-throughput

0.486

High

829763

GTS1
Protein GTS1

1

0

High-throughput

0.486

High

1040657

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.486

High

1040663

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

0

High-throughput

0.486

High

1040665

MHR1
Large ribosomal subunit protein mL67

1

0

High-throughput

0.486

High

1040666

DIB1
Spliceosomal protein DIB1

1

0

High-throughput

0.486

High

796115

IMB2
Importin subunit beta-2

1

0

Small-scale

0.480

High

364709

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

709946

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

760334

BMH2
Protein BMH2

1

1

High-throughput

0.479

High

893290

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

Small-scale

0.479

High

382302

H4
Histone H4

1

0

High-throughput

0.458

High

435313

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

448331

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

561517

TBP
TATA-box-binding protein

1

0

High-throughput

0.458

High

680000

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

697392

MIG1
Regulatory protein MIG1

1

0

High-throughput

0.458

High

707989

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

735132

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

741081

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.458

High

754181

MSN2
Zinc finger protein MSN2

1

0

High-throughput

0.458

High

776636

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

779962

DOA1
Protein DOA1

1

0

Small-scale

0.458

High

792215

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

925009

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

963676

H3
Histone H3

1

0

High-throughput

0.458

High

1026811

CDC14
Tyrosine-protein phosphatase CDC14

1

0

High-throughput

0.458

High

1040660

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

1040661

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

1040664

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

1040667

PBP4
Protein PBP4

1

0

High-throughput

0.458

High

1040671

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

1040672

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

1040674

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.458

High

488992

SWI6
Regulatory protein SWI6

1

1

High-throughput

0.445

High

671552

SWI4
Regulatory protein SWI4

1

1

High-throughput

0.445

High

742255

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

819610

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

579949

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.437

High

381229

H2B1
Histone H2B.1

1

0

High-throughput

0.426

High

548794

MCM1
Pheromone receptor transcription factor

1

0

High-throughput

0.426

High

671053

SIS1
Protein SIS1

1

0

High-throughput

0.426

High

781792

SET3
SET domain-containing protein 3

1

0

High-throughput

0.426

High

793869

SWD3
COMPASS component SWD3

1

0

High-throughput

0.426

High

893331

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.426

High

1036330

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.426

High

1040673

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.426

High

733820

VPS10
Vacuolar protein sorting/targeting protein VPS10

2

0

High-throughput

0.324

High

808544

TEM1
Protein TEM1

2

0

High-throughput

0.314

High

1040669

ADY3
Accumulates dyads protein 3

2

0

High-throughput

0.307

High

805429

BZZ1
Protein BZZ1

1

0

High-throughput

0.282

High

1010267

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.282

High

782426

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.279

Low

923111

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.279

Low

554040

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.265

Low

737202

HYM1
Protein HYM1

1

0

High-throughput

0.265

Low

738689

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.265

Low

743440

MSS4
Protein DSS4

1

0

High-throughput

0.265

Low

744263

ISC10
Meiosis-specific protein ISC10

1

0

High-throughput

0.265

Low

798459

NTM1
Alpha N-terminal protein methyltransferase 1

1

0

High-throughput

0.265

Low

822392

HUA1
Proline-rich protein HUA1

1

0

High-throughput

0.265

Low

865208

MRX12
MIOREX complex component 12

1

0

High-throughput

0.265

Low

1039139

MUK1
Protein MUK1

1

0

High-throughput

0.265

Low

1040668

YD057
Putative uncharacterized protein YDL057W

1

0

High-throughput

0.265

Low

149926

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

383864

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

410308

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433818

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

442080

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

503209

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

512615

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

513184

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

514801

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

674800

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

689630

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

747548

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

753552

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

802352

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

812603

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

874493

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

1033528

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

1040662

PAL1
Protein PAL1

1

0

High-throughput

0.249

Low

1040670

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

818677

YE18
Uncharacterized protein YER188W

1

0

High-throughput

0.238

Low

864061

MRX5
MIOREX complex component 5

1

0

High-throughput

0.238

Low

1040676

YI105
Uncharacterized protein YIL105W-A

1

0

High-throughput

0.238

Low

453758

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

626866

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low

748234

VAM7
Vacuolar morphogenesis protein 7

1

0

High-throughput

0.232

Low

752651

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

824529

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.232

Low

863706

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025