Protein: TRP
Tryptophan synthase (EC 4.2.1.20)

Gene: TRP, TRP5
Organism: Saccharomyces cerevisiae S288C
Interactions: 57
UniProt ID: P00931

Gene Ontology (top 5):
GO:0000162 - L-tryptophan biosynthetic process
GO:0004834 - tryptophan synthase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

368260

SMT3
Ubiquitin-like protein SMT3

2

1

High-throughput

0.600

High

368243

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

368251

GCN5
Histone acetyltransferase GCN5

2

0

High-throughput

0.576

High

368242

SSB2
Ribosome-associated molecular chaperone SSB2

2

6

High-throughput

0.552

High

368221

FKBP
FK506-binding protein 1

1

1

High-throughput

0.536

High

368241

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.536

High

368210

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.513

High

368246

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.513

High

368219

EI2BA
Translation initiation factor eIF2B subunit alpha

1

1

High-throughput

0.489

High

368213

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

368208

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

368209

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

1

High-throughput

0.479

High

368214

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.479

High

368218

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.479

High

368220

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

368223

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

368224

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

368226

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

368227

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

368228

HOG1
Mitogen-activated protein kinase HOG1

1

2

High-throughput

0.479

High

368232

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

368237

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

368253

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

368255

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

368259

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

368263

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

368225

PRP45
Pre-mRNA-processing protein 45

1

0

Small-scale

0.460

High

368217

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.458

High

368222

PSB4
Proteasome subunit beta type-4

1

0

Small-scale

0.458

High

368231

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

368234

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

368236

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

368247

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

368248

H3
Histone H3

1

0

High-throughput

0.458

High

368249

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.458

High

368250

ESP1
Separin

1

0

High-throughput

0.458

High

368252

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

368256

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

368258

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

368215

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

368216

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

368229

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

368233

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

368244

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

368261

HSP42
Heat shock protein 42

1

1

High-throughput

0.445

High

368240

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

368254

SYRC
Arginine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.437

High

368257

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

368262

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.437

High

368238

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.426

High

368239

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

368264

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.426

High

368211

NFT1
ABC transporter NFT1

1

0

High-throughput

0.282

High

368230

ISC10
Meiosis-specific protein ISC10

1

0

High-throughput

0.265

Low

368212

YK104
Putative uncharacterized protein YKR104W

1

0

High-throughput

0.251

Low

368235

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

368245

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025