Protein: CYC8
General transcriptional corepressor CYC8 (Glucose repression mediator protein CYC8)

Gene: CYC8
Organism: Saccharomyces cerevisiae S288C
Interactions: 88
UniProt ID: P14922

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

542095

TUP1
General transcriptional corepressor TUP1

21

16

Small-scale

0.991

High

542111

HIR1
Protein HIR1

1

12

Small-scale

0.740

High

542106

MIG1
Regulatory protein MIG1

5

9

Small-scale

0.708

High

542156

CTI6
Histone deacetylase complex subunit CTI6

3

3

Small-scale

0.670

High

542148

NRG1
Transcriptional regulator NRG1

3

15

Small-scale

0.665

High

542092

CYC8
General transcriptional corepressor CYC8

1

12

Small-scale

0.647

High

542146

SKO1
CRE-binding bZIP protein SKO1

3

0

Small-scale

0.634

High

542114

RGT1
Glucose transport transcription regulator RGT1

3

0

Small-scale

0.633

High

542139

HOS2
Probable histone deacetylase HOS2

2

12

Small-scale

0.623

High

542112

RPD3
Histone deacetylase RPD3

2

13

Small-scale

0.618

High

542138

SUT1
Sterol uptake protein 1

2

0

Small-scale

0.605

High

542136

RFX1
RFX-like DNA-binding protein RFX1

2

0

Small-scale

0.591

High

542094

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

3

Small-scale

0.584

High

381590

GAL80
Galactose/lactose metabolism regulatory protein GAL80

2

0

Small-scale

0.577

High

493097

HSP72
Heat shock protein SSA2

2

15

Small-scale

0.571

High

542103

MAS5
Mitochondrial protein import protein MAS5

2

13

Small-scale

0.571

High

542098

OPI1
Transcriptional repressor OPI1

2

0

Small-scale

0.569

High

542134

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

13

Small-scale

0.561

High

542128

MED3
Mediator of RNA polymerase II transcription subunit 3

1

0

Small-scale

0.557

High

542099

AFT1
Iron-regulated transcriptional activator AFT1

1

0

Small-scale

0.537

High

542096

SFL1
Flocculation suppression protein

1

1

Small-scale

0.527

High

542120

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

5

High-throughput

0.515

High

542159

HOS1
Histone deacetylase HOS1

1

10

Small-scale

0.515

High

542158

MED2
Mediator of RNA polymerase II transcription subunit 2

1

0

Small-scale

0.513

High

542161

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.513

High

542143

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

9

High-throughput

0.508

High

542147

CUS1
Cold sensitive U2 snRNA suppressor 1

1

1

High-throughput

0.508

High

542119

RTG3
Retrograde regulation protein 3

1

0

Small-scale

0.504

High

542101

ROX1
Repressor ROX1

1

13

Small-scale

0.501

High

542104

DAL80
Nitrogen regulatory protein DAL80

1

6

Small-scale

0.501

High

542116

YOX1
Homeobox protein YOX1

1

6

Small-scale

0.501

High

542153

YHP1
Homeobox protein YHP1

1

3

Small-scale

0.501

High

542109

BEM1
Bud emergence protein 1

1

5

High-throughput

0.494

High

542121

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

7

High-throughput

0.494

High

542150

STE20
Serine/threonine-protein kinase STE20

1

11

Small-scale

0.481

High

542160

SMT3
Ubiquitin-like protein SMT3

1

3

High-throughput

0.481

High

425283

PHO4
Phosphate system positive regulatory protein PHO4

1

0

Small-scale

0.480

High

483017

HMAL2
Silenced mating-type protein ALPHA2

1

0

Small-scale

0.480

High

542100

URE2
Transcriptional regulator URE2

1

0

Small-scale

0.480

High

542105

INO2
Protein INO2

1

0

Small-scale

0.480

High

542124

UME6
Transcriptional regulatory protein UME6

1

0

Small-scale

0.480

High

542131

HAC1
Transcriptional activator HAC1

1

0

Small-scale

0.480

High

542141

MOT3
Transcriptional activator/repressor MOT3

1

0

Small-scale

0.480

High

376611

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

5

Small-scale

0.479

High

406739

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

415878

DED1
ATP-dependent RNA helicase DED1

1

6

Small-scale

0.479

High

542102

SIS1
Protein SIS1

1

15

High-throughput

0.479

High

542117

DEF1
RNA polymerase II degradation factor 1

1

7

High-throughput

0.479

High

542129

YAP4
AP-1-like transcription factor YAP4

1

1

Small-scale

0.479

High

542130

GTS1
Protein GTS1

1

1

Small-scale

0.479

High

542133

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

5

High-throughput

0.479

High

542144

NOP3
Serine/arginine

1

12

Small-scale

0.479

High

542149

GCN5
Histone acetyltransferase GCN5

1

14

Small-scale

0.479

High

542151

YAP6
AP-1-like transcription factor YAP6

1

1

Small-scale

0.479

High

542162

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

11

Small-scale

0.479

High

542126

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

542108

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

542118

PHD1
Putative transcription factor PHD1

1

0

Small-scale

0.458

High

542122

SDO1L
Restriction of telomere capping protein 3

1

0

High-throughput

0.458

High

542123

SKN7
Transcription factor SKN7

1

0

Small-scale

0.458

High

542132

CUP9
Homeobox protein CUP9

1

0

Small-scale

0.458

High

542152

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

542154

SIZ1
E3 SUMO-protein ligase SIZ1

1

0

High-throughput

0.458

High

542157

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

490212

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.445

High

510128

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.445

High

542113

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

542125

CAJ1
Protein CAJ1

1

20

High-throughput

0.445

High

542127

SSB2
Ribosome-associated molecular chaperone SSB2

1

15

High-throughput

0.445

High

542140

APJ1
J domain-containing protein APJ1

1

15

High-throughput

0.445

High

367684

EF1A
Elongation factor 1-alpha

1

4

Small-scale

0.437

High

425727

RS19A
Small ribosomal subunit protein eS19A

1

2

Small-scale

0.437

High

426257

RS19B
Small ribosomal subunit protein eS19B

1

2

Small-scale

0.437

High

481274

RL2A
Large ribosomal subunit protein uL2A

1

2

Small-scale

0.437

High

534871

RL3
Large ribosomal subunit protein uL3

1

2

Small-scale

0.437

High

542093

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

Small-scale

0.437

High

542097

SAR1
Small COPII coat GTPase SAR1

1

1

Small-scale

0.437

High

542115

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.437

High

542145

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

541602

SEC63
Protein translocation protein SEC63

1

20

High-throughput

0.407

High

542107

ERV1
Mitochondrial FAD-linked sulfhydryl oxidase ERV1

1

0

Small-scale

0.261

Low

536278

CPYI
Carboxypeptidase Y inhibitor

1

0

High-throughput

0.249

Low

542110

ACH1
Acetyl-CoA hydrolase

1

0

Small-scale

0.249

Low

542135

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

542137

PSP2
Protein PSP2

1

0

Small-scale

0.249

Low

542142

PURA
Adenylosuccinate synthetase

1

0

Small-scale

0.249

Low

542155

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024