Protein: SYWC
Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS)

Gene: SYWC, WRS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 37
UniProt ID: Q12109

Gene Ontology (top 5):
GO:0004830 - tryptophan-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006436 - tryptophanyl-tRNA aminoacylation
GO:1990825 - sequence-specific mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

724893

RAD16
DNA repair protein RAD16

2

2

High-throughput

0.621

High

820080

SSB2
Ribosome-associated molecular chaperone SSB2

2

3

High-throughput

0.552

High

525491

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.536

High

546682

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.536

High

850248

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.533

High

671228

SIS1
Protein SIS1

2

2

High-throughput

0.521

High

416578

HXKB
Hexokinase-2

1

0

High-throughput

0.493

High

558897

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

680148

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

803714

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

815272

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

922660

HST2
NAD-dependent protein deacetylase HST2

1

1

High-throughput

0.479

High

623972

MYO2
Myosin-2

1

0

Small-scale

0.460

High

417194

VDAC1
Non-selective voltage-gated ion channel 1

1

0

Small-scale

0.458

High

735218

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

1059409

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

393501

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

527973

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

511525

RL44A
Large ribosomal subunit protein eL42A

1

1

High-throughput

0.437

High

511605

RL44B
Large ribosomal subunit protein eL42B

1

1

High-throughput

0.437

High

594629

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.437

High

708491

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

803822

RRF1
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.437

High

806831

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

812754

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

1054002

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

1065530

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

676454

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

692451

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.426

High

811428

CAJ1
Protein CAJ1

1

1

High-throughput

0.407

High

1056450

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

1

High-throughput

0.407

High

1084315

GDIR
Rho GDP-dissociation inhibitor

1

0

High-throughput

0.251

Low

795265

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

797082

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

825815

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

917526

YGL7
Uncharacterized protein YGL117W

1

0

High-throughput

0.249

Low

1084316

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025