Protein: HST2
NAD-dependent protein deacetylase HST2 (EC 2.3.1.286) (Homologous to SIR2 protein 2) (Regulatory protein SIR2 homolog 2)

Gene: HST2
Organism: Saccharomyces cerevisiae S288C
Interactions: 135
UniProt ID: P53686

Gene Ontology (top 5):
GO:0000183 - rDNA heterochromatin formation
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0017136 - histone deacetylase activity, NAD-dependent
GO:0045950 - negative regulation of mitotic recombination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

922642

H3
Histone H3

3

10

Small-scale

0.862

High

922634

HST2
NAD-dependent protein deacetylase HST2

1

13

High-throughput

0.618

High

722135

XPO1
Exportin-1

2

8

High-throughput

0.611

High

922655

RT109
Histone acetyltransferase RTT109

1

0

Small-scale

0.480

High

368350

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

6

High-throughput

0.479

High

386808

TBB
Tubulin beta chain

1

4

High-throughput

0.479

High

400074

PUR1
Amidophosphoribosyltransferase

1

4

High-throughput

0.479

High

454123

DHE4
NADP-specific glutamate dehydrogenase 1

1

3

High-throughput

0.479

High

455583

SYSC
Serine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

475174

CISY2
Citrate synthase, peroxisomal

1

6

High-throughput

0.479

High

486269

TBA1
Tubulin alpha-1 chain

1

5

High-throughput

0.479

High

486500

TBA3
Tubulin alpha-3 chain

1

5

High-throughput

0.479

High

548711

RNA1
Ran GTPase-activating protein 1

1

4

High-throughput

0.479

High

561692

RPOM
DNA-directed RNA polymerase, mitochondrial

1

2

High-throughput

0.479

High

592404

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.479

High

638112

OSM1
Fumarate reductase 2

1

2

High-throughput

0.479

High

649651

KCC2
Calcium/calmodulin-dependent protein kinase II

1

1

High-throughput

0.479

High

654797

URE2
Transcriptional regulator URE2

1

1

High-throughput

0.479

High

664453

MCM3
DNA replication licensing factor MCM3

1

12

High-throughput

0.479

High

670312

NAP1
Nucleosome assembly protein

1

4

High-throughput

0.479

High

673383

NFS1
Cysteine desulfurase, mitochondrial

1

3

High-throughput

0.479

High

701727

URA7
CTP synthase 1

1

1

High-throughput

0.479

High

707786

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

709898

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

713013

MCM2
DNA replication licensing factor MCM2

1

12

High-throughput

0.479

High

721395

MCM4
DNA replication licensing factor MCM4

1

14

High-throughput

0.479

High

733593

P5CR
Pyrroline-5-carboxylate reductase

1

3

High-throughput

0.479

High

734709

IMB3
Importin subunit beta-3

1

7

High-throughput

0.479

High

740683

CBS
Cystathionine beta-synthase

1

1

High-throughput

0.479

High

746745

KPR1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.479

High

757843

PP2C3
Protein phosphatase 2C homolog 3

1

1

High-throughput

0.479

High

763471

MDJ1
DnaJ homolog 1, mitochondrial

1

4

High-throughput

0.479

High

779429

MAOM
NAD-dependent malic enzyme, mitochondrial

1

2

High-throughput

0.479

High

781721

SA190
SIT4-associating protein SAP190

1

3

High-throughput

0.479

High

796105

IMB2
Importin subunit beta-2

1

9

High-throughput

0.479

High

800909

NCB5R
NADH-cytochrome b5 reductase 1

1

2

High-throughput

0.479

High

800932

URA8
CTP synthase 2

1

1

High-throughput

0.479

High

802668

YHI0
Putative proline--tRNA ligase YHR020W

1

2

High-throughput

0.479

High

802760

RRP3
ATP-dependent rRNA helicase RRP3

1

4

High-throughput

0.479

High

811361

CAJ1
Protein CAJ1

1

5

High-throughput

0.479

High

813566

MET10
Sulfite reductase [NADPH] flavoprotein component

1

1

High-throughput

0.479

High

816088

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

3

High-throughput

0.479

High

823133

RFC2
Replication factor C subunit 2

1

2

High-throughput

0.479

High

863358

NMD5
Nonsense-mediated mRNA decay protein 5

1

8

High-throughput

0.479

High

865021

TCPQ
T-complex protein 1 subunit theta

1

7

High-throughput

0.479

High

866226

MET5
Sulfite reductase [NADPH] subunit beta

1

1

High-throughput

0.479

High

915376

VPS4
Vacuolar protein sorting-associated protein 4

1

3

High-throughput

0.479

High

916733

PPP5
Serine/threonine-protein phosphatase T

1

7

High-throughput

0.479

High

917041

MCM6
DNA replication licensing factor MCM6

1

14

High-throughput

0.479

High

922635

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

High-throughput

0.479

High

922637

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

922646

ELP3
Elongator complex protein 3

1

1

High-throughput

0.479

High

922648

RUVB1
RuvB-like protein 1

1

4

High-throughput

0.479

High

922649

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

922651

HFD1
Fatty aldehyde dehydrogenase HFD1

1

8

High-throughput

0.479

High

922652

ARP9
Actin-like protein ARP9

1

2

High-throughput

0.479

High

922659

MDN1
Midasin

1

11

High-throughput

0.479

High

922660

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

922661

KPR5
Ribose-phosphate pyrophosphokinase 5

1

2

High-throughput

0.479

High

922662

GYP5
GTPase-activating protein GYP5

1

1

High-throughput

0.479

High

922664

RUVB2
RuvB-like protein 2

1

4

High-throughput

0.479

High

922665

YO098
Uncharacterized protein YOL098C

1

8

High-throughput

0.479

High

367499

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.458

High

470722

MET3
Sulfate adenylyltransferase

1

0

High-throughput

0.458

High

521124

PRI1
DNA primase small subunit

1

0

High-throughput

0.458

High

553638

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.458

High

585179

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.458

High

625970

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.458

High

646194

SLY1
Protein SLY1

1

0

High-throughput

0.458

High

672615

ATX10
Ataxin-10 homolog

1

0

High-throughput

0.458

High

715426

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.458

High

737149

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

1

0

High-throughput

0.458

High

754135

HIS5
Imidazole glycerol phosphate synthase hisHF

1

0

High-throughput

0.458

High

804140

PANE
2-dehydropantoate 2-reductase

1

0

High-throughput

0.458

High

808805

LYS9
Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]

1

0

High-throughput

0.458

High

809158

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

High-throughput

0.458

High

849791

GYP8
GTPase-activating protein GYP8

1

0

High-throughput

0.458

High

865631

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

871519

HGH1
Protein HGH1

1

0

High-throughput

0.458

High

916547

TEL2
Telomere length regulation protein TEL2

1

0

High-throughput

0.458

High

919487

ZPR1
Zinc finger chaperone ZPR1

1

0

High-throughput

0.458

High

922641

ERG13
Hydroxymethylglutaryl-CoA synthase

1

0

High-throughput

0.458

High

922643

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.458

High

922645

FMP30
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrial

1

0

High-throughput

0.458

High

922647

RMT2
Protein arginine N-methyltransferase 2

1

0

High-throughput

0.458

High

922656

ETT1
Enhancer of translation termination 1

1

0

High-throughput

0.458

High

922658

ETFD
Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.458

High

922663

DPH6
Diphthine--ammonia ligase

1

0

High-throughput

0.458

High

545753

SSB1
Ribosome-associated molecular chaperone SSB1

1

14

High-throughput

0.445

High

742089

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

816335

HSP7E
Heat shock protein SSC3, mitochondrial

1

15

High-throughput

0.445

High

819386

SSB2
Ribosome-associated molecular chaperone SSB2

1

14

High-throughput

0.445

High

922657

ESA1
Histone acetyltransferase ESA1

1

5

Small-scale

0.445

High

367084

ATPB
ATP synthase subunit beta, mitochondrial

1

4

High-throughput

0.437

High

368182

THDH
Threonine dehydratase, mitochondrial

1

1

High-throughput

0.437

High

452042

TOM70
Mitochondrial import receptor subunit TOM70

1

1

High-throughput

0.437

High

452945

ATPA
ATP synthase subunit alpha, mitochondrial

1

5

High-throughput

0.437

High

484313

KEX1
Pheromone-processing carboxypeptidase KEX1

1

1

High-throughput

0.437

High

488663

HEM1
5-aminolevulinate synthase, mitochondrial

1

2

High-throughput

0.437

High

567699

ACOX
Acyl-coenzyme A oxidase

1

5

High-throughput

0.437

High

626836

HSP60
Heat shock protein 60, mitochondrial

1

8

High-throughput

0.437

High

668460

SPTC1
Serine palmitoyltransferase 1

1

2

High-throughput

0.437

High

734783

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

2

High-throughput

0.437

High

737540

EUG1
Protein disulfide-isomerase EUG1

1

3

High-throughput

0.437

High

781887

CAF4
CCR4-associated factor 4

1

8

High-throughput

0.437

High

793393

ATG42
Vacuolar serine-type carboxypeptidase ATG42

1

1

High-throughput

0.437

High

798063

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

5

High-throughput

0.437

High

800879

GUAA
GMP synthase [glutamine-hydrolyzing]

1

6

High-throughput

0.437

High

811002

TCPD
T-complex protein 1 subunit delta

1

5

High-throughput

0.437

High

815991

VAC8
Vacuolar protein 8

1

12

High-throughput

0.437

High

817501

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

7

High-throughput

0.437

High

826334

EPS1
ER-retained PMA1-suppressing protein 1

1

3

High-throughput

0.437

High

856553

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

7

High-throughput

0.437

High

865577

ARP3
Actin-related protein 3

1

2

High-throughput

0.437

High

874281

MON2
Protein MON2

1

1

High-throughput

0.437

High

922639

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

7

High-throughput

0.437

High

922653

SGPL
Sphingosine-1-phosphate lyase

1

3

High-throughput

0.437

High

528619

CP51
Lanosterol 14-alpha demethylase CYP51

1

0

High-throughput

0.249

Low

555118

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.249

Low

631977

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.249

Low

677083

MGR1
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR1

1

0

High-throughput

0.249

Low

728657

OCH1
Initiation-specific alpha-1,6-mannosyltransferase

1

0

High-throughput

0.249

Low

737581

ERG1
Squalene epoxidase ERG1

1

0

High-throughput

0.249

Low

781433

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

816597

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.249

Low

835063

OST1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

878380

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.249

Low

919602

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.249

Low

922636

YNT3
Uncharacterized protein YNL193W

1

0

High-throughput

0.249

Low

922638

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

922640

ERG5
C-22 sterol desaturase ERG5

1

0

High-throughput

0.249

Low

922644

ARG56
Protein ARG5,6, mitochondrial [Cleaved into: N-acetyl-gamma-glutamyl-phosphate reductase

1

0

High-throughput

0.249

Low

922650

GPI17
GPI transamidase component GPI17

1

0

High-throughput

0.249

Low

922654

OMS1
Methyltransferase OMS1, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025