Protein: PRK1
Actin-regulating kinase PRK1 (EC 2.7.11.1) (p53-regulating kinase 1)

Gene: PRK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 115
UniProt ID: P40494

Gene Ontology (top 5):
GO:0000147 - actin cortical patch assembly
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

551370

ABP1
Actin-binding protein

6

4

Small-scale

0.746

High

689354

ARP2
Actin-related protein 2

1

3

Small-scale

0.740

High

692229

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

6

7

Small-scale

0.734

High

376812

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

High-throughput

0.691

High

420293

CALM
Calmodulin

1

12

High-throughput

0.691

High

743883

AKL1
Serine/threonine-protein kinase AKL1

1

17

High-throughput

0.691

High

774614

CDC14
Tyrosine-protein phosphatase CDC14

1

6

High-throughput

0.691

High

697945

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

3

11

Small-scale

0.683

High

615156

BUR1
Serine/threonine-protein kinase BUR1

1

11

High-throughput

0.665

High

649903

CDC15
Cell division control protein 15

1

18

High-throughput

0.647

High

710380

EDE1
EH domain-containing and endocytosis protein 1

1

13

Small-scale

0.647

High

765632

BEM2
GTPase-activating protein BEM2/IPL2

1

6

Small-scale

0.647

High

774611

ACT
Actin

1

1

High-throughput

0.646

High

704785

SLA2
Protein SLA2

2

15

Small-scale

0.619

High

774630

YRA1
RNA annealing protein YRA1

1

5

High-throughput

0.618

High

543874

HSC82
ATP-dependent molecular chaperone HSC82

1

9

High-throughput

0.618

High

747606

OPY1
Protein OPY1

1

0

High-throughput

0.614

High

712936

BMH2
Protein BMH2

2

20

High-throughput

0.611

High

756304

AP18A
Clathrin coat assembly protein AP180A

3

13

Small-scale

0.609

High

774633

LAS17
Proline-rich protein LAS17

2

3

Small-scale

0.595

High

774592

PRK1
Actin-regulating kinase PRK1

1

17

High-throughput

0.590

High

765454

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

6

High-throughput

0.587

High

707022

MSN4
Zinc finger protein MSN4

1

1

High-throughput

0.579

High

774607

AP18B
Clathrin coat assembly protein AP180B

2

14

High-throughput

0.570

High

774602

BUD4
Bud site selection protein 4

1

0

High-throughput

0.541

High

748537

ARPC1
Actin-related protein 2/3 complex subunit 1

1

8

High-throughput

0.541

High

597847

PWP1
Periodic tryptophan protein 1

1

3

High-throughput

0.536

High

698090

YSC84
Protein YSC84

1

7

High-throughput

0.536

High

741548

VRP1
Verprolin

1

1

High-throughput

0.536

High

751373

FKS1
1,3-beta-glucan synthase component FKS1

1

1

High-throughput

0.536

High

759230

END3
Actin cytoskeleton-regulatory complex protein END3

1

11

High-throughput

0.536

High

766047

HSP7E
Heat shock protein SSC3, mitochondrial

1

10

High-throughput

0.536

High

774616

DYL1
Dynein light chain 1, cytoplasmic

1

2

High-throughput

0.536

High

774635

ENT1
Epsin-1

1

5

High-throughput

0.536

High

774624

TSR1
Ribosome biogenesis protein TSR1

1

2

High-throughput

0.515

High

628146

SIS1
Protein SIS1

1

2

High-throughput

0.514

High

774621

ENT2
Epsin-2

1

5

High-throughput

0.508

High

430781

SYV
Valine--tRNA ligase, mitochondrial

1

1

Small-scale

0.501

High

482570

YA11A
Transposon Ty1-A Gag polyprotein

1

2

High-throughput

0.501

High

482625

YE11A
Transposon Ty1-ER1 Gag polyprotein

1

1

High-throughput

0.501

High

563963

SEC2
Rab guanine nucleotide exchange factor SEC2

1

3

High-throughput

0.501

High

635297

SYP1
Suppressor of yeast profilin deletion

1

1

Small-scale

0.501

High

640969

RL5
Large ribosomal subunit protein uL18

1

2

Small-scale

0.501

High

713193

SCD5
Protein SCD5

1

1

Small-scale

0.501

High

747554

AIM3
Altered inheritance of mitochondria protein 3

1

5

High-throughput

0.501

High

755400

SFB3
SED5-binding protein 3

1

5

Small-scale

0.501

High

767054

ARB1
ABC transporter ATP-binding protein ARB1

1

2

High-throughput

0.501

High

774594

BNI1
Protein BNI1

1

3

Small-scale

0.501

High

774596

LSB3
LAS seventeen-binding protein 3

1

8

High-throughput

0.501

High

774598

SAC3
Nuclear mRNA export protein SAC3

1

1

Small-scale

0.501

High

774603

MET5
Sulfite reductase [NADPH] subunit beta

1

2

Small-scale

0.501

High

774615

RNT1
Ribonuclease 3

1

1

High-throughput

0.501

High

774632

YD21A
Transposon Ty2-DR1 Gag polyprotein

1

2

High-throughput

0.501

High

774634

YN12A
Transposon Ty1-NL2 Gag polyprotein

1

2

High-throughput

0.501

High

588107

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.500

High

604425

CLH
Clathrin heavy chain

1

5

High-throughput

0.500

High

774626

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.500

High

774627

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

1

High-throughput

0.500

High

410501

CYSD
Homocysteine/cysteine synthase

1

0

High-throughput

0.480

High

417587

PHSG
Glycogen phosphorylase

1

0

Small-scale

0.480

High

746398

NCL1
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase

1

0

Small-scale

0.480

High

747617

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.480

High

751255

AGM1
Phosphoacetylglucosamine mutase

1

0

High-throughput

0.480

High

753406

ECM29
Proteasome component ECM29

1

0

Small-scale

0.480

High

767886

SHO1
High osmolarity signaling protein SHO1

1

0

High-throughput

0.480

High

774593

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.480

High

774597

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.480

High

774617

ADD37
Alpha1-proteinase inhibitor-degradation deficient protein 37

1

0

High-throughput

0.480

High

774618

RMD1
Sporulation protein RMD1

1

0

Small-scale

0.480

High

774620

UFO1
Ubiquitin ligase complex F-box protein UFO1

1

0

Small-scale

0.480

High

774623

SYM1
Protein SYM1

1

0

High-throughput

0.480

High

774625

HBT1
Protein HBT1

1

0

High-throughput

0.480

High

774628

KAD6
Adenylate kinase isoenzyme 6 homolog FAP7

1

0

High-throughput

0.480

High

664877

BMH1
Protein BMH1

1

20

High-throughput

0.479

High

774604

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.479

High

685536

COPG
Coatomer subunit gamma

1

16

Small-scale

0.457

High

699602

LIPA
Lipoyl synthase, mitochondrial

1

1

High-throughput

0.457

High

751976

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

4

High-throughput

0.457

High

753631

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

3

High-throughput

0.457

High

772383

VPS27
Vacuolar protein sorting-associated protein 27

1

3

High-throughput

0.457

High

774601

DPB11
DNA replication regulator DPB11

1

1

Small-scale

0.457

High

774609

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

6

High-throughput

0.457

High

774610

YL460
Uncharacterized protein YLR460C

1

1

High-throughput

0.457

High

774636

RS25A
Small ribosomal subunit protein eS25A

1

1

High-throughput

0.457

High

397600

OTC
Ornithine carbamoyltransferase

1

2

High-throughput

0.457

High

581298

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.457

High

478258

HSP77
Import motor subunit, mitochondrial

1

10

High-throughput

0.445

High

491453

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

494153

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

511588

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

694845

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.445

High

773657

6P21
6-phosphofructo-2-kinase 1

1

3

High-throughput

0.445

High

662432

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

774613

NUM1
Nuclear migration protein NUM1

1

16

High-throughput

0.437

High

766514

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.426

High

774612

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.296

High

764003

SAW1
Single-strand annealing weakened protein 1

1

0

High-throughput

0.269

Low

774595

BRE2
COMPASS component BRE2

1

0

High-throughput

0.269

Low

520385

TRK1
High-affinity potassium transport protein

1

0

Small-scale

0.261

Low

604689

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.261

Low

698267

CDC13
Cell division control protein 13

1

0

High-throughput

0.261

Low

698503

GYP6
GTPase-activating protein GYP6

1

0

High-throughput

0.261

Low

698551

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.261

Low

754241

RSC30
Chromatin structure-remodeling complex protein RSC30

1

0

High-throughput

0.261

Low

763981

HPH2
Protein HPH2

1

0

High-throughput

0.261

Low

774599

STB2
Protein STB2

1

0

High-throughput

0.261

Low

774600

GON7
EKC/KEOPS complex subunit GON7

1

0

Small-scale

0.261

Low

774605

NU188
Nucleoporin NUP188

1

0

Small-scale

0.261

Low

774606

MST27
Multicopy suppressor of SEC21 protein 27

1

0

High-throughput

0.261

Low

774608

REXO1
RNA exonuclease 1

1

0

High-throughput

0.261

Low

774619

YMD7
Uncharacterized protein YML037C

1

0

High-throughput

0.261

Low

774622

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.261

Low

774629

SAS10
Something about silencing protein 10

1

0

High-throughput

0.261

Low

774631

YO093
Uncharacterized protein YOR093C

1

0

Small-scale

0.261

Low


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Last updated: 15 Jul 2024