Protein: ERG3
Delta(7)-sterol 5(6)-desaturase ERG3 (EC 1.14.19.20) (C-5 sterol desaturase ERG3) (Ergosterol Delta(5,6) desaturase ERG3) (Ergosterol biosynthetic protein 3) (Sterol-C5-desaturase)

Gene: ERG3
Organism: Saccharomyces cerevisiae S288C
Interactions: 55
UniProt ID: P32353

Gene Ontology (top 5):
GO:0000170 - sphingosine hydroxylase activity
GO:0000248 - C-5 sterol desaturase activity
GO:0000254 - C-4 methylsterol oxidase activity
GO:0005506 - iron ion binding
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

688610

ERG25
C-4 methylsterol oxidase ERG25

2

4

Small-scale

0.632

High

688587

ERG24
Delta(14)-sterol reductase ERG24

2

1

Small-scale

0.614

High

688600

ERG28
Ergosterol biosynthetic protein 28

2

2

Small-scale

0.614

High

495806

CP51
Lanosterol 14-alpha demethylase CYP51

2

3

Small-scale

0.576

High

626418

ERG6
Sterol 24-C-methyltransferase ERG6

1

1

Small-scale

0.541

High

669523

ERG9
Squalene synthase ERG9

1

1

Small-scale

0.541

High

688586

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

4

High-throughput

0.541

High

688594

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.541

High

688596

ERG7
Lanosterol synthase ERG7

1

1

Small-scale

0.541

High

688611

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

2

Small-scale

0.541

High

688615

TMEDA
Endoplasmic reticulum vesicle protein 25

1

6

High-throughput

0.541

High

688626

ERG27
3-keto-steroid reductase ERG27

1

1

Small-scale

0.541

High

688597

SEC72
Translocation protein SEC72

1

0

High-throughput

0.518

High

688625

SMF3
Iron transporter SMF3

1

0

High-throughput

0.518

High

688624

TPO1
Polyamine transporter 1

1

3

High-throughput

0.494

High

688588

ERG1
Squalene epoxidase ERG1

1

1

High-throughput

0.479

High

688593

PHO88
SRP-independent targeting protein 3

1

2

High-throughput

0.479

High

688595

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

1

High-throughput

0.479

High

688601

CYB5
Cytochrome b5

1

5

High-throughput

0.479

High

688602

ELO3
Fatty acid elongase 3

1

6

High-throughput

0.479

High

688608

HLJ1
Protein HLJ1

1

1

High-throughput

0.479

High

688619

GSF2
Glucose-signaling factor 2

1

2

High-throughput

0.479

High

688620

RTN1
Reticulon-like protein 1

1

1

High-throughput

0.479

High

688627

ENV10
SRP-independent targeting protein 2

1

2

High-throughput

0.479

High

688606

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.458

High

688607

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

688621

HRD3
ERAD-associated E3 ubiquitin-protein ligase component HRD3

1

0

Small-scale

0.458

High

688623

ORM2
Protein ORM2

1

2

High-throughput

0.457

High

688612

COPA
Coatomer subunit alpha

1

1

High-throughput

0.437

High

688618

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.437

High

688622

IMB1
Importin subunit beta-1

1

1

High-throughput

0.437

High

449954

HSP73
Heat shock protein SSA3

1

5

High-throughput

0.407

High

477998

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.407

High

490614

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.407

High

493433

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.407

High

510581

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.407

High

688590

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.407

High

688598

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.407

High

688599

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.407

High

688609

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.407

High

605942

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.249

Low

661600

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

688589

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

688591

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.249

Low

688592

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

688604

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.249

Low

688605

COPB
Coatomer subunit beta

1

0

High-throughput

0.249

Low

688613

BRE5
UBP3-associated protein BRE5

1

0

Small-scale

0.249

Low

688616

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

Small-scale

0.249

Low

688617

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

612211

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.232

Low

633030

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.232

Low

688603

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.232

Low

688614

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024