Protein: APC5
Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5)

Gene: APC5, ANAPC5
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q9UJX4

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005819 - spindle
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

718653

CDC27
Cell division cycle protein 27 homolog

20

10

Small-scale

0.986

High

1460754

APC4
Anaphase-promoting complex subunit 4

10

1

Small-scale

0.969

High

1460721

CDC23
Cell division cycle protein 23 homolog

5

12

High-throughput

0.922

High

1430910

APC1
Anaphase-promoting complex subunit 1

5

1

Small-scale

0.903

High

1460745

APC7
Anaphase-promoting complex subunit 7

5

12

Small-scale

0.892

High

948605

APC15
Anaphase-promoting complex subunit 15

3

0

Small-scale

0.816

High

1460755

ANC2
Anaphase-promoting complex subunit 2

7

4

Small-scale

0.741

High

1086932

CDC20
Cell division cycle protein 20 homolog

7

6

Small-scale

0.737

High

1093080

CDC16
Cell division cycle protein 16 homolog

6

12

High-throughput

0.734

High

1460758

FZR1
Fizzy-related protein homolog

6

6

Small-scale

0.728

High

908870

NEK2
Serine/threonine-protein kinase Nek2

4

1

Small-scale

0.683

High

1460763

LMBL1
Lethal(3)malignant brain tumor-like protein 1

4

0

High-throughput

0.667

High

1387379

APC16
Anaphase-promoting complex subunit 16

4

0

High-throughput

0.661

High

1340920

CDC26
Anaphase-promoting complex subunit CDC26

4

0

High-throughput

0.658

High

1412128

APC13
Anaphase-promoting complex subunit 13

4

0

High-throughput

0.658

High

1460757

FBX5
F-box only protein 5

3

0

Small-scale

0.642

High

1448706

LATS2
Serine/threonine-protein kinase LATS2

3

0

Small-scale

0.634

High

292878

GRAP2
GRB2-related adapter protein 2

2

2

High-throughput

0.611

High

1195401

ANO6
Anoctamin-6

2

0

High-throughput

0.602

High

1429695

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.602

High

1460762

CRYL1
Lambda-crystallin homolog

2

0

High-throughput

0.602

High

251819

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

2

1

High-throughput

0.601

High

1460759

APC10
Anaphase-promoting complex subunit 10

2

3

High-throughput

0.601

High

1106116

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.586

High

419264

H2A1B
Histone H2A type 1-B/E

2

0

High-throughput

0.585

High

1116110

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

0

High-throughput

0.585

High

1129779

MDC1
Mediator of DNA damage checkpoint protein 1

2

1

Small-scale

0.584

High

1233814

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.576

High

397177

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1367542

ESR2
Estrogen receptor beta

2

1

High-throughput

0.571

High

1384294

SH3K1
SH3 domain-containing kinase-binding protein 1

2

1

High-throughput

0.571

High

1368520

CBP
CREB-binding protein

1

3

Small-scale

0.561

High

1029168

E2F1
Transcription factor E2F1

2

0

Small-scale

0.559

High

1287025

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

2

0

Small-scale

0.559

High

550510

PABP1
Polyadenylate-binding protein 1

1

0

Small-scale

0.549

High

1115127

CUL4A
Cullin-4A

1

1

High-throughput

0.536

High

951896

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.530

High

166581

BACH1
Transcription regulator protein BACH1

1

0

High-throughput

0.518

High

1051436

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.518

High

1195421

Q4KMX6
Anaphase-promoting complex subunit 7

1

12

High-throughput

0.514

High

186350

RA51B
DNA repair protein RAD51 homolog 2

1

0

High-throughput

0.513

High

244878

TRAK2
Trafficking kinesin-binding protein 2

1

0

High-throughput

0.513

High

296845

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

347400

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

538081

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

857585

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.513

High

872863

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

884265

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

902909

BLK
Tyrosine-protein kinase Blk

1

0

High-throughput

0.513

High

992375

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.513

High

1099812

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1148079

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.513

High

1163273

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

1242373

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.513

High

1394992

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.513

High

1407012

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.513

High

1412922

NAA11
N-alpha-acetyltransferase 11

1

0

High-throughput

0.513

High

1417902

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1420257

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1434769

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

1460756

HSPB8
Heat shock protein beta-8

1

0

High-throughput

0.513

High

1451032

RBM28
RNA-binding protein 28

1

1

High-throughput

0.489

High

1161255

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.486

High

1036557

ID2
DNA-binding protein inhibitor ID-2

1

0

Small-scale

0.480

High

1162717

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

Small-scale

0.480

High

173524

XPO1
Exportin-1

1

2

High-throughput

0.479

High

687535

PTBP1
Polypyrimidine tract-binding protein 1

1

1

High-throughput

0.479

High

908892

NEK3
Serine/threonine-protein kinase Nek3

1

1

High-throughput

0.479

High

1067814

EP300
Histone acetyltransferase p300

1

4

Small-scale

0.479

High

1089055

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1114608

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1141353

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.479

High

1257162

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.479

High

1280584

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1336878

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

2

Small-scale

0.479

High

1437677

PKHA5
Pleckstrin homology domain-containing family A member 5

1

1

Small-scale

0.479

High

1452593

APC11
Anaphase-promoting complex subunit 11

1

1

Small-scale

0.479

High

1460279

XPO7
Exportin-7

1

2

High-throughput

0.479

High

221303

DCX
Neuronal migration protein doublecortin

1

0

Small-scale

0.458

High

290197

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

1435426

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

316131

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

320792

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

342360

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.458

High

589989

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696814

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

700752

PSA5
Proteasome subunit alpha type-5

1

0

Small-scale

0.458

High

769467

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

831617

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

920346

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

972607

RS14
Small ribosomal subunit protein uS11

1

0

Small-scale

0.458

High

980511

H4
Histone H4

1

0

High-throughput

0.458

High

998928

H31
Histone H3.1

1

0

High-throughput

0.458

High

1122875

TFDP1
Transcription factor Dp-1

1

0

Small-scale

0.458

High

1135847

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1276934

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1310809

CUL9
Cullin-9

1

0

Small-scale

0.458

High

1329932

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1335055

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1349741

CMAP3
Ciliary microtubule-associated protein 3

1

0

High-throughput

0.458

High

1415903

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1431420

CDT1
DNA replication factor Cdt1

1

0

Small-scale

0.458

High

1433114

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1433859

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

0

High-throughput

0.458

High

1453033

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1460760

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

Small-scale

0.458

High

1460761

PHF8
Histone lysine demethylase PHF8

1

0

Small-scale

0.458

High

1434185

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1454768

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.437

High

49035

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.426

High

224390

BUB3
Mitotic checkpoint protein BUB3

1

0

High-throughput

0.426

High

839640

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.426

High

916721

PPP5
Serine/threonine-protein phosphatase 5

1

0

High-throughput

0.426

High

934297

BI1
Bax inhibitor 1

1

0

High-throughput

0.426

High

1391838

AURKB
Aurora kinase B

1

0

High-throughput

0.426

High

370431

KNG1
Kininogen-1

3

0

High-throughput

0.347

High

377087

PENK
Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin

3

0

High-throughput

0.347

High

1435266

MAGIX
PDZ domain-containing protein MAGIX

3

0

High-throughput

0.347

High

1244448

CP087
UPF0547 protein C16orf87

3

0

High-throughput

0.345

High

1339406

GP156
Probable G-protein coupled receptor 156

3

0

High-throughput

0.345

High

351293

TTLL1
Polyglutamylase complex subunit TTLL1

2

0

High-throughput

0.318

High

295653

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.279

Low

1177121

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

1211464

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.279

Low

1231487

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

1381168

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

1396463

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

1402735

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1439405

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.279

Low

1454469

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

1249314

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1256019

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1202129

HS904
Putative heat shock protein HSP 90-alpha A4

1

0

High-throughput

0.232

Low

1248751

SBSN
Suprabasin

1

0

High-throughput

0.232

Low

1357256

S38A5
Sodium-coupled neutral amino acid transporter 5

1

0

High-throughput

0.232

Low

1454125

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025