Protein: GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q)

Gene: GNAQ
Organism: Homo sapiens
Interactions: 118
UniProt ID: P50148

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0001750 - photoreceptor outer segment
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
GO:0005096 - GTPase activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

640498

TA2R
Thromboxane A2 receptor

8

20

Small-scale

0.963

High

669115

ARBK1
Beta-adrenergic receptor kinase 1

4

8

Small-scale

0.908

High

893526

RIC8A
Chaperone Ric-8A

3

15

Small-scale

0.880

High

890697

RGS4
Regulator of G-protein signaling 4

3

20

Small-scale

0.865

High

893527

PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

2

3

Small-scale

0.825

High

893500

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

2

20

High-throughput

0.789

High

893535

TA2R7
Taste receptor type 2 member 7

2

1

High-throughput

0.789

High

192035

RGS16
Regulator of G-protein signaling 16

1

20

Small-scale

0.724

High

326436

S1PR2
Sphingosine 1-phosphate receptor 2

1

20

High-throughput

0.691

High

638174

S1PR1
Sphingosine 1-phosphate receptor 1

1

20

High-throughput

0.691

High

893482

ANK2
Ankyrin-2

1

3

High-throughput

0.691

High

893533

RIC8B
Chaperone Ric-8B

1

15

Small-scale

0.680

High

893477

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

3

20

High-throughput

0.662

High

833397

RGS2
Regulator of G-protein signaling 2

1

20

Small-scale

0.647

High

890709

RGS7
Regulator of G-protein signaling 7

1

20

Small-scale

0.647

High

893488

GRM7
Metabotropic glutamate receptor 7

1

1

Small-scale

0.647

High

893519

MRGX1
Mas-related G-protein coupled receptor member X1

1

20

Small-scale

0.647

High

893531

RGS18
Regulator of G-protein signaling 18

1

20

Small-scale

0.647

High

893466

GBG4

2

20

High-throughput

0.628

High

893479

GBG3

2

20

High-throughput

0.628

High

893529

DUS22
Dual specificity protein phosphatase 22

2

15

High-throughput

0.628

High

177370

ARHGB
Rho guanine nucleotide exchange factor 11

1

20

Small-scale

0.618

High

193883

RGS5
Regulator of G-protein signaling 5

1

20

Small-scale

0.618

High

669382

PAR1
Proteinase-activated receptor 1

1

20

Small-scale

0.618

High

720653

AGTR1
Type-1 angiotensin II receptor

1

14

Small-scale

0.618

High

732960

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

9

Small-scale

0.618

High

733309

CCR1
C-C chemokine receptor type 1

1

19

High-throughput

0.618

High

733743

CXCR5
C-X-C chemokine receptor type 5

1

14

Small-scale

0.618

High

762195

CRFR1
Corticotropin-releasing factor receptor 1

1

9

Small-scale

0.618

High

845501

PI2R
Prostacyclin receptor

1

20

Small-scale

0.618

High

893481

PLCB2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

1

3

Small-scale

0.618

High

893492

AGRF1
Adhesion G-protein coupled receptor F1

1

8

Small-scale

0.618

High

893515

ARHG1
Rho guanine nucleotide exchange factor 1

1

20

Small-scale

0.618

High

893516

KISSR
KiSS-1 receptor

1

20

Small-scale

0.618

High

893536

ARHGC
Rho guanine nucleotide exchange factor 12

1

13

Small-scale

0.618

High

893490

DGUOK
Deoxyguanosine kinase, mitochondrial

2

1

High-throughput

0.611

High

893498

MOT14
Monocarboxylate transporter 14

2

5

High-throughput

0.611

High

893534

KTU
Protein kintoun

2

1

High-throughput

0.611

High

893532

ATG3
Ubiquitin-like-conjugating enzyme ATG3

2

0

High-throughput

0.602

High

893467

GBG10

2

20

High-throughput

0.601

High

893542

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

2

20

High-throughput

0.601

High

475925

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

12

High-throughput

0.575

High

893495

CXB7
Gap junction beta-7 protein

2

3

High-throughput

0.574

High

893483

BTK
Tyrosine-protein kinase BTK

1

1

Small-scale

0.561

High

893489

CYH1
Cytohesin-1

1

4

Small-scale

0.561

High

893523

CYH2
Cytohesin-2

1

4

Small-scale

0.561

High

478665

HXB5
Homeobox protein Hox-B5

2

4

High-throughput

0.558

High

893506

S2541
Mitochondrial carrier protein SCaMC-3L

2

3

High-throughput

0.558

High

893507

T185A
Transmembrane protein 185A

2

3

High-throughput

0.558

High

893521

UIF
UAP56-interacting factor

2

3

High-throughput

0.558

High

893522

CCNL2
Cyclin-L2

2

2

High-throughput

0.558

High

893541

NUFP1
FMR1-interacting protein NUFIP1

2

3

High-throughput

0.558

High

893485

AKP13
A-kinase anchor protein 13

1

17

Small-scale

0.553

High

893469

GPM6A
Neuronal membrane glycoprotein M6-a

1

2

High-throughput

0.536

High

893472

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

20

High-throughput

0.536

High

893478

GBG1
Guanine nucleotide-binding protein G(T) subunit gamma-T1

1

20

High-throughput

0.536

High

893480

GBG5

1

20

High-throughput

0.536

High

893504

ZDH23
Palmitoyltransferase ZDHHC23

1

5

High-throughput

0.536

High

893514

KIFA3
Kinesin-associated protein 3

1

1

High-throughput

0.536

High

893517

ISG20
Interferon-stimulated gene 20 kDa protein

1

3

High-throughput

0.536

High

893537

GBG12

1

20

High-throughput

0.536

High

893543

PCDGK
Protocadherin gamma-C3

1

1

High-throughput

0.536

High

893544

TACC3
Transforming acidic coiled-coil-containing protein 3

1

1

High-throughput

0.536

High

893493

IQEC1
IQ motif and SEC7 domain-containing protein 1

2

3

Small-scale

0.533

High

893468

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.518

High

893470

LUM
Lumican

1

0

High-throughput

0.518

High

893502

HOT
Hydroxyacid-oxoacid transhydrogenase, mitochondrial

1

0

High-throughput

0.518

High

893525

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.518

High

520536

RARA
Retinoic acid receptor alpha

1

6

Small-scale

0.515

High

387808

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

High-throughput

0.513

High

893496

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.513

High

893499

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

1

0

High-throughput

0.513

High

893509

LHPL5
LHFPL tetraspan subfamily member 5 protein

1

0

High-throughput

0.513

High

893510

EXOC6
Exocyst complex component 6

1

0

High-throughput

0.513

High

893530

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

0

High-throughput

0.513

High

124751

AIP
AH receptor-interacting protein

1

6

Small-scale

0.501

High

882413

ARRB1
Beta-arrestin-1

1

0

Small-scale

0.493

High

893486

MED21
Mediator of RNA polymerase II transcription subunit 21

1

1

High-throughput

0.489

High

893503

CMIP
C-Maf-inducing protein

1

3

High-throughput

0.489

High

893518

CERS2
Ceramide synthase 2

1

3

High-throughput

0.489

High

893528

ANLN
Anillin

1

10

High-throughput

0.489

High

124271

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.479

High

164287

NRP1
Neuropilin-1

1

5

High-throughput

0.479

High

225473

CYH3
Cytohesin-3

1

4

Small-scale

0.479

High

330765

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

374470

RASH
GTPase HRas

1

12

High-throughput

0.479

High

593737

PECA1
Platelet endothelial cell adhesion molecule

1

2

Small-scale

0.479

High

597344

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

1

20

Small-scale

0.479

High

633890

ATP4A
Potassium-transporting ATPase alpha chain 1

1

6

Small-scale

0.479

High

838967

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

Small-scale

0.479

High

893475

ABCE1
ATP-binding cassette sub-family E member 1

1

2

High-throughput

0.479

High

893476

ARF6
ADP-ribosylation factor 6

1

1

Small-scale

0.479

High

893484

CD47
Leukocyte surface antigen CD47

1

1

Small-scale

0.479

High

893497

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

893538

HDAC6
Protein deacetylase HDAC6

1

7

High-throughput

0.479

High

893540

UBQL2
Ubiquilin-2

1

2

High-throughput

0.479

High

893524

TTC1
Tetratricopeptide repeat protein 1

1

8

Small-scale

0.470

High

699651

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.458

High

183916

S22A2
Solute carrier family 22 member 2

1

6

High-throughput

0.445

High

254884

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

529353

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.445

High

893471

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

893473

CD81
CD81 antigen

1

8

High-throughput

0.445

High

893487

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

12

High-throughput

0.445

High

893494

PKHA7
Pleckstrin homology domain-containing family A member 7

1

14

High-throughput

0.445

High

893512

CTL1
Choline transporter-like protein 1

1

6

High-throughput

0.445

High

893520

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

15

High-throughput

0.445

High

63723

PSD1
PH and SEC7 domain-containing protein 1

1

4

Small-scale

0.437

High

105583

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

694938

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

893508

WDR36
WD repeat-containing protein 36

1

4

Small-scale

0.437

High

893513

ESR2
Estrogen receptor beta

1

10

High-throughput

0.437

High

893511

CMAP3
Ciliary microtubule-associated protein 3

2

0

High-throughput

0.318

High

893474

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

0

High-throughput

0.279

Low

893491

TIGD5
Tigger transposable element-derived protein 5

1

0

High-throughput

0.279

Low

893501

C1QL4
Complement C1q-like protein 4

1

0

High-throughput

0.279

Low

893505

ZN843
Zinc finger protein 843

1

0

High-throughput

0.279

Low

893539

PARP2
Poly [ADP-ribose] polymerase 2

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025