Protein: NICA
Nicastrin

Gene: NICA, Ncstn
Organism: Mus musculus
Interactions: 15
UniProt ID: P57716

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002262 - myeloid cell homeostasis
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

944782

PEN2
Gamma-secretase subunit PEN-2

1

3

Small-scale

0.646

High

890087

PSN1
Presenilin-1

3

6

Small-scale

0.624

High

944784

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

3

Small-scale

0.534

High

944779

APH1A
Gamma-secretase subunit APH-1A

1

6

Small-scale

0.515

High

571207

CALR
Calreticulin

1

2

Small-scale

0.479

High

944777

PSN2
Presenilin-2

1

6

Small-scale

0.479

High

944780

APH1B
Gamma-secretase subunit APH-1B

1

6

Small-scale

0.479

High

944786

TMED2
Transmembrane emp24 domain-containing protein 2

1

1

Small-scale

0.479

High

944775

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

944781

TREM2
Triggering receptor expressed on myeloid cells 2

1

0

Small-scale

0.458

High

944785

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

Small-scale

0.458

High

944776

GSAP
Gamma-secretase-activating protein

1

1

Small-scale

0.457

High

944783

APMAP
Adipocyte plasma membrane-associated protein

1

0

Small-scale

0.426

High

944787

ARC
Activity-regulated cytoskeleton-associated protein

1

0

Small-scale

0.426

High

944778

FACD2
Fanconi anemia group D2 protein homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025