Protein: PSN1
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]

Gene: PSN1, Psen1
Organism: Mus musculus
Interactions: 30
UniProt ID: P49769

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0000776 - kinetochore
GO:0001568 - blood vessel development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

890099

PEN2
Gamma-secretase subunit PEN-2

4

7

Small-scale

0.867

High

890097

APH1A
Gamma-secretase subunit APH-1A

2

10

Small-scale

0.776

High

890085

PSN1
Presenilin-1

2

7

Small-scale

0.767

High

890090

CTNB1
Catenin beta-1

3

2

Small-scale

0.640

High

771444

NMDZ1
Glutamate receptor ionotropic, NMDA 1

3

1

Small-scale

0.633

High

890087

NICA
Nicastrin

3

6

Small-scale

0.624

High

890094

PSN2
Presenilin-2

1

7

Small-scale

0.618

High

890098

APH1B
Gamma-secretase subunit APH-1B

1

10

Small-scale

0.618

High

890102

GSK3B
Glycogen synthase kinase-3 beta

2

1

Small-scale

0.595

High

890093

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

1

Small-scale

0.515

High

855289

SYT1
Synaptotagmin-1

1

1

Small-scale

0.500

High

890103

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

Small-scale

0.493

High

890101

ARC
Activity-regulated cytoskeleton-associated protein

1

0

Small-scale

0.479

High

204903

NOTC2
Neurogenic locus notch homolog protein 2

1

10

Small-scale

0.479

High

486814

CADH1
Cadherin-1

1

5

Small-scale

0.479

High

580354

CADH2
Cadherin-2

1

6

Small-scale

0.479

High

686944

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

Small-scale

0.479

High

728037

NOTC4
Neurogenic locus notch homolog protein 4

1

11

Small-scale

0.479

High

771410

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

1

Small-scale

0.479

High

890089

NOTC1
Neurogenic locus notch homolog protein 1

1

11

Small-scale

0.479

High

890095

DLL1
Delta-like protein 1

1

11

Small-scale

0.479

High

890096

NOTC3
Neurogenic locus notch homolog protein 3

1

11

Small-scale

0.479

High

890100

TMED2
Transmembrane emp24 domain-containing protein 2

1

1

Small-scale

0.479

High

571206

CALR
Calreticulin

1

0

Small-scale

0.458

High

890086

EFNB1
Ephrin-B1

1

0

Small-scale

0.458

High

890088

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

0

Small-scale

0.458

High

890091

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.458

High

890104

PLD1
Phospholipase D1

1

0

Small-scale

0.458

High

890092

GSAP
Gamma-secretase-activating protein

1

1

Small-scale

0.457

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025