HitPredict

Interactor 1: KCNH2 (Q12809)
Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)
Gene: KCNH2

Interactor 2: KCNH7 (Q9NS40)
Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (hERG-3) (Voltage-gated potassium channel subunit Kv11.3)
Gene: KCNH7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.47 1.00 0.691

The method score is based on:

Property Details
Experiments 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains cNMP_binding~cNMP_binding, Ion_trans~cNMP_binding, PAS_9~cNMP_binding, Ion_trans~Ion_trans, PAS_9~PAS_9
Common GO terms GO:0005242 - inward rectifier potassium channel activity
GO:0005886 - plasma membrane
GO:0042391 - regulation of membrane potential
GO:0071805 - potassium ion transmembrane transport
GO:0086011 - membrane repolarization during action potential
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 1159
Hs

1 1196
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Last updated: 15 Jul 2024