Protein: RN168
E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168)

Gene: RN168, RNF168
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q8IYW5

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003682 - chromatin binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

419077

H2A1B
Histone H2A type 1-B/E

9

12

Small-scale

0.971

High

957787

UBE2N
Ubiquitin-conjugating enzyme E2 N

7

7

Small-scale

0.962

High

957130

UB2D3
Ubiquitin-conjugating enzyme E2 D3

6

7

Small-scale

0.940

High

1162827

H2A2C
Histone H2A type 2-C

5

12

Small-scale

0.930

High

591726

H2AX
Histone H2AX

4

13

Small-scale

0.882

High

502050

H2AZ
Histone H2A.Z

3

14

Small-scale

0.845

High

906703

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

7

Small-scale

0.845

High

982242

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

7

Small-scale

0.845

High

754908

H2B1B
Histone H2B type 1-B

3

13

Small-scale

0.834

High

1163049

H2B2E
Histone H2B type 2-E

2

13

Small-scale

0.768

High

1232693

H2A2A
Histone H2A type 2-A

2

12

Small-scale

0.768

High

508264

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

8

4

Small-scale

0.750

High

952444

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

4

High-throughput

0.698

High

1107912

SQSTM
Sequestosome-1

3

3

Small-scale

0.667

High

277740

H2AY
Core histone macro-H2A.1

1

13

Small-scale

0.647

High

502425

H2A1
Histone H2A type 1

1

12

Small-scale

0.647

High

909344

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

7

Small-scale

0.647

High

995992

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

7

High-throughput

0.647

High

1272803

H2A3
Histone H2A type 3

1

12

Small-scale

0.647

High

1315650

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

7

Small-scale

0.647

High

1315654

KMT5A
N-lysine methyltransferase KMT5A

2

1

Small-scale

0.634

High

1062545

DHX9
ATP-dependent RNA helicase A

2

3

Small-scale

0.624

High

1315661

RNF11
RING finger protein 11

2

1

High-throughput

0.620

High

998529

H31
Histone H3.1

1

7

High-throughput

0.618

High

596223

H12
Histone H1.2

2

6

Small-scale

0.608

High

1315652

TRIM8
E3 ubiquitin-protein ligase TRIM8

2

3

High-throughput

0.606

High

1315640

RN168
E3 ubiquitin-protein ligase RNF168

2

7

Small-scale

0.602

High

246747

KDM1A
Lysine-specific histone demethylase 1A

2

0

Small-scale

0.598

High

507269

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

4

Small-scale

0.595

High

1088908

TP53B
TP53-binding protein 1

2

9

Small-scale

0.584

High

560888

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

2

0

High-throughput

0.580

High

542574

TOP2A
DNA topoisomerase 2-alpha

1

2

Small-scale

0.561

High

639266

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

2

Small-scale

0.561

High

964360

SUMO2
Small ubiquitin-related modifier 2

1

3

Small-scale

0.561

High

1315648

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

Small-scale

0.561

High

1315658

HDAC6
Protein deacetylase HDAC6

1

0

Small-scale

0.554

High

617321

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

0

Small-scale

0.537

High

1294943

PALB2
Partner and localizer of BRCA2

1

0

Small-scale

0.537

High

1315645

DGCR8
Microprocessor complex subunit DGCR8

1

0

Small-scale

0.537

High

1315651

RN126
E3 ubiquitin-protein ligase RNF126

1

0

Small-scale

0.537

High

325924

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

Small-scale

0.536

High

1129340

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

2

Small-scale

0.536

High

1253850

SRCAP
Helicase SRCAP

1

5

High-throughput

0.536

High

1315653

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

1

High-throughput

0.536

High

1315662

NUB1
NEDD8 ultimate buster 1

1

1

High-throughput

0.536

High

1315663

TACC3
Transforming acidic coiled-coil-containing protein 3

1

3

High-throughput

0.536

High

1123710

DCTN1
Dynactin subunit 1

1

5

High-throughput

0.515

High

128016

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.513

High

628813

TBP
TATA-box-binding protein

1

0

High-throughput

0.513

High

1244775

CC174
Coiled-coil domain-containing protein 174

1

0

High-throughput

0.513

High

1151448

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

Small-scale

0.505

High

487515

PARP1
Poly [ADP-ribose] polymerase 1

1

3

Small-scale

0.501

High

791519

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

1110920

LAPM5
Lysosomal-associated transmembrane protein 5

1

0

High-throughput

0.486

High

1219295

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

Small-scale

0.481

High

273435

KDM4A
Lysine-specific demethylase 4A

1

0

Small-scale

0.480

High

455822

H10
Histone H1.0

1

0

Small-scale

0.480

High

207587

DHX15
ATP-dependent RNA helicase DHX15

1

3

Small-scale

0.479

High

243675

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

3

Small-scale

0.479

High

260168

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

342951

HERC2
E3 ubiquitin-protein ligase HERC2

1

2

Small-scale

0.479

High

466349

RHOC
Rho-related GTP-binding protein RhoC

1

11

Small-scale

0.479

High

620468

NUCL
Nucleolin

1

5

Small-scale

0.479

High

799285

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

854157

KI67
Proliferation marker protein Ki-67

1

9

Small-scale

0.479

High

910582

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

4

Small-scale

0.479

High

939210

SUMO3
Small ubiquitin-related modifier 3

1

3

Small-scale

0.479

High

979966

H4
Histone H4

1

2

High-throughput

0.479

High

991363

SUMO1
Small ubiquitin-related modifier 1

1

3

Small-scale

0.479

High

1004805

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1045497

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1058880

ZO1
Tight junction protein 1

1

2

Small-scale

0.479

High

1061599

FOXM1
Forkhead box protein M1

1

1

Small-scale

0.479

High

1087861

NFIA
Nuclear factor 1 A-type

1

2

High-throughput

0.479

High

1102017

PABP4
Polyadenylate-binding protein 4

1

5

Small-scale

0.479

High

1130781

RRP5
Protein RRP5 homolog

1

1

Small-scale

0.479

High

1131069

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.479

High

1133527

NFIX
Nuclear factor 1 X-type

1

3

High-throughput

0.479

High

1137848

TNIP1
TNFAIP3-interacting protein 1

1

4

High-throughput

0.479

High

1315643

COP1
E3 ubiquitin-protein ligase COP1

1

2

High-throughput

0.479

High

1315647

KAT6A
Histone acetyltransferase KAT6A

1

4

High-throughput

0.479

High

1315657

RAI14
Ankycorbin

1

3

Small-scale

0.479

High

1315659

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1315660

LIMA1
LIM domain and actin-binding protein 1

1

2

Small-scale

0.479

High

566750

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.470

High

1315649

WBP2
WW domain-binding protein 2

1

0

Small-scale

0.460

High

214448

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

0

Small-scale

0.458

High

353877

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.458

High

569121

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.458

High

613097

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

838135

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.458

High

904332

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

929994

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

Small-scale

0.458

High

1143410

PCM1
Pericentriolar material 1 protein

1

0

Small-scale

0.458

High

1281556

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1315641

CGAS
Cyclic GMP-AMP synthase

1

0

Small-scale

0.458

High

1315646

H1X
Histone H1.10

1

0

Small-scale

0.458

High

1315655

DDX21
Nucleolar RNA helicase 2

1

0

Small-scale

0.458

High

1315656

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.458

High

1315642

RN169
E3 ubiquitin-protein ligase RNF169

1

1

Small-scale

0.445

High

1160683

DREB
Drebrin

1

5

Small-scale

0.437

High

1315644

DEN10
DENN domain-containing protein 10

1

0

High-throughput

0.279

Low

301548

WFS1
Wolframin

1

0

High-throughput

0.268

Low

1155159

EREP1
Endosomal transmembrane epsin interactor 1

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025