HitPredict

Interactor 1: ANK3 (Q12955)
Ankyrin-3 (ANK-3) (Ankyrin-G)
Gene: ANK3

Interactor 2: MICA3 (Q7RTP6)
[F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3)
Gene: MICAL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	34079125, 27528609
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~LIM
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 4377 Hs			1 2002
+	Hs
		963306 ANK3_HUMAN (1-4377): 0: 1944: 100.00		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		164611 ANK3_HUMAN (1-4377): 0: 1944: 100.00		SPTN2_HUMAN (433-1216): 1.38e-79: 295: 14.86
+	Hs
		1021404 ANK3_HUMAN (1-4377): 0: 1944: 100.00		PLEC_HUMAN (619-1989): 3.73e-11: 71.1: 10.87
+	Mm
		103609 ANK3_MOUSE (3991-4376): 7.67e-34: 147: 40.98		MICA3_MOUSE (1-2002): 0: 1292: 86.01
+	Hs
		556695 ANK1_HUMAN (1-683): 0: 722: 34.22		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		506803 ANK1_HUMAN (1-683): 0: 722: 34.22		SPTB1_HUMAN (433-1059): 1.05e-83: 309: 16.54
+	Hs
		211682 ANFY1_HUMAN (270-925): 8.88e-121: 417: 18.16		ACTN4_HUMAN (434-1045): 2.63e-104: 359: 14.72
+	Hs
		1232340 ANFY1_HUMAN (270-925): 8.88e-121: 417: 18.16		MILK1_HUMAN (715-885): 2.96e-16: 87.2: 21.14
+	Mm
		103603 ANK3_MOUSE (3991-4376): 7.67e-34: 147: 40.98		SPTB2_MOUSE (433-1059): 1.63e-86: 318: 16.72
+	Mm
		103598 ANK3_MOUSE (3991-4376): 7.67e-34: 147: 40.98		Q3UGX2_MOUSE (433-1125): 4.55e-84: 310: 15.98
+	Hs
		963292 ANK2_HUMAN (3012-4350): 1.52e-22: 110: 9.15		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		164604 ANK2_HUMAN (3012-4350): 1.52e-22: 110: 9.15		SPTN2_HUMAN (433-1216): 1.38e-79: 295: 14.86
+	Mm
		57440 A2AM57_MOUSE (4-259): 8.55e-52: 204: 25.76		PLEC_MOUSE (599-2002): 8.98e-28: 125: 12.51
+	Mm
		57416 A2AM57_MOUSE (4-259): 8.55e-52: 204: 25.76		Q6S385_MOUSE (619-1989): 6.33e-09: 63.8: 10.06
+	Dm
		65570 A8JNM5_DROME (619-1164): 1.22e-40: 169: 17.10		FUTSC_DROME (624-1841): 5.12e-12: 74: 11.12
+	Dm
		1376672 FUTSC_DROME (2038-4130): 9.59e-38: 160: 10.13		FUTSC_DROME (624-1841): 5.12e-12: 74: 11.12
+	Dm
		113976 M9PB30_DROME (3680-4368): 3.7e-19: 99: 6.57		M9PB30_DROME (593-1222): 7.98e-10: 66.7: 9.76