Protein: LCAP
Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form]

Gene: LCAP, LNPEP
Organism: Homo sapiens
Interactions: 206
UniProt ID: Q9UIQ6

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0002480 - antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0004177 - aminopeptidase activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1432024

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

4

2

Small-scale

0.709

High

380375

DRA
HLA class II histocompatibility antigen, DR alpha chain

4

10

High-throughput

0.691

High

609836

LEG3
Galectin-3

4

5

High-throughput

0.691

High

699240

CALX
Calnexin

4

5

High-throughput

0.691

High

125655

LEG9
Galectin-9

3

5

High-throughput

0.667

High

127411

LEG8
Galectin-8

3

5

High-throughput

0.667

High

627584

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

10

High-throughput

0.667

High

1430572

LMA2L
VIP36-like protein

3

2

High-throughput

0.662

High

1334055

DHB11
Estradiol 17-beta-dehydrogenase 11

3

2

High-throughput

0.653

High

332459

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

3

2

Small-scale

0.646

High

376070

RASK
GTPase KRas

3

6

High-throughput

0.640

High

378200

TNFA
Tumor necrosis factor

3

0

High-throughput

0.638

High

460286

CD3E
T-cell surface glycoprotein CD3 epsilon chain

3

0

High-throughput

0.638

High

1249596

BTNL8
Butyrophilin-like protein 8

3

0

High-throughput

0.638

High

665330

EDNRB
Endothelin receptor type B

2

4

High-throughput

0.628

High

1251074

SG1D4
Secretoglobin family 1D member 4

2

3

High-throughput

0.628

High

580719

AMPN
Aminopeptidase N

1

7

High-throughput

0.618

High

1437650

SIAE
Sialate O-acetylesterase

2

1

High-throughput

0.611

High

456028

ASGR2
Asialoglycoprotein receptor 2

2

1

High-throughput

0.606

High

690424

STOM
Stomatin

2

4

High-throughput

0.606

High

1009744

NGAL
Neutrophil gelatinase-associated lipocalin

2

1

High-throughput

0.606

High

1352549

GPX8
Probable glutathione peroxidase 8

2

1

High-throughput

0.606

High

1449961

S39A9
Zinc transporter ZIP9

2

2

High-throughput

0.606

High

1460468

UBQL1
Ubiquilin-1

2

1

High-throughput

0.606

High

1081681

TM267
Transmembrane protein 267

2

0

High-throughput

0.602

High

390805

TFR1
Transferrin receptor protein 1

2

1

High-throughput

0.601

High

480923

LEG1
Galectin-1

2

5

High-throughput

0.601

High

1010120

DLK1
Protein delta homolog 1

2

2

High-throughput

0.601

High

1460464

FBX2
F-box only protein 2

2

6

High-throughput

0.601

High

1293692

DYR2
Dihydrofolate reductase 2, mitochondrial

2

0

High-throughput

0.585

High

1403683

GPHA2
Glycoprotein hormone alpha-2

2

0

High-throughput

0.585

High

218931

TGON2
Trans-Golgi network integral membrane protein 2

2

2

High-throughput

0.584

High

374266

RASN
GTPase NRas

2

6

High-throughput

0.584

High

374999

RASH
GTPase HRas

2

4

High-throughput

0.584

High

631011

RAB4A
Ras-related protein Rab-4A

2

4

High-throughput

0.584

High

631544

RAB5A
Ras-related protein Rab-5A

2

3

High-throughput

0.584

High

902134

RAB9A
Ras-related protein Rab-9A

2

5

High-throughput

0.584

High

976642

RB11A
Ras-related protein Rab-11A

2

3

High-throughput

0.584

High

978385

RHOB
Rho-related GTP-binding protein RhoB

2

9

High-throughput

0.584

High

1448309

FBX6
F-box only protein 6

2

6

High-throughput

0.584

High

947910

T2R19
Taste receptor type 2 member 19

2

0

High-throughput

0.580

High

1006318

CTG1B
Cancer/testis antigen 1

2

0

High-throughput

0.580

High

1109092

AQP6
Aquaporin-6

2

0

High-throughput

0.580

High

1280826

S35E3
Solute carrier family 35 member E3

2

0

High-throughput

0.580

High

1292382

UN93A
Protein unc-93 homolog A

2

0

High-throughput

0.580

High

1326945

EMC5
ER membrane protein complex subunit 5

2

0

High-throughput

0.580

High

1347218

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

0

High-throughput

0.580

High

1359335

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.580

High

1396413

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.580

High

1398491

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.580

High

1406333

CGRF1
Cell growth regulator with RING finger domain protein 1

2

0

High-throughput

0.580

High

1460463

GGT7
Glutathione hydrolase 7

2

0

High-throughput

0.580

High

1049049

REL
Proto-oncogene c-Rel

1

1

High-throughput

0.573

High

397168

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

171010

CLGN
Calmegin

2

5

High-throughput

0.549

High

351745

SG1D1
Secretoglobin family 1D member 1

1

3

High-throughput

0.536

High

351984

S1PR4
Sphingosine 1-phosphate receptor 4

1

4

High-throughput

0.536

High

370049

CYTC
Cystatin-C

1

1

High-throughput

0.536

High

380495

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

10

High-throughput

0.536

High

701437

5HT1B
5-hydroxytryptamine receptor 1B

1

3

High-throughput

0.536

High

1185369

LEG9B
Galectin-9B

1

5

High-throughput

0.536

High

1218873

GP107
Protein GPR107

1

1

High-throughput

0.536

High

1363251

AQP3
Aquaporin-3

1

1

High-throughput

0.536

High

1405151

DNJC2
DnaJ homolog subfamily C member 2

1

4

High-throughput

0.536

High

1439376

SDF2L
Stromal cell-derived factor 2-like protein 1

1

1

High-throughput

0.536

High

1448781

RNC
Ribonuclease 3

1

1

High-throughput

0.536

High

1458672

DNJB9
DnaJ homolog subfamily B member 9

1

5

High-throughput

0.536

High

1460471

HYOU1
Hypoxia up-regulated protein 1

1

4

High-throughput

0.536

High

1460473

ST14
Suppressor of tumorigenicity 14 protein

1

3

High-throughput

0.536

High

189031

TMPS2
Transmembrane protease serine 2

1

3

High-throughput

0.515

High

693123

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

1286951

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.515

High

1448848

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.515

High

193466

GPR42
G-protein coupled receptor 42

1

8

High-throughput

0.515

High

66950

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.513

High

142233

CCL22
C-C motif chemokine 22

1

0

High-throughput

0.513

High

344501

STR3N
STARD3 N-terminal-like protein

1

0

High-throughput

0.513

High

376650

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.513

High

548145

PSPC
Surfactant protein C

1

0

High-throughput

0.513

High

658538

GLRA2
Glycine receptor subunit alpha-2

1

0

High-throughput

0.513

High

904445

CP2J2
Cytochrome P450 2J2

1

0

High-throughput

0.513

High

1108889

PNOC
Prepronociceptin [Cleaved into: Nocistatin; Nociceptin

1

0

High-throughput

0.513

High

1168761

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.513

High

1251138

PNCB
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.513

High

1279001

TAFA5
Chemokine-like protein TAFA-5

1

0

High-throughput

0.513

High

1356743

TM263
Transmembrane protein 263

1

0

High-throughput

0.513

High

1386149

GCC1
GRIP and coiled-coil domain-containing protein 1

1

0

High-throughput

0.513

High

1453754

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.513

High

360146

NB5R3
NADH-cytochrome b5 reductase 3

1

2

High-throughput

0.481

High

1134184

NTCP
Hepatic sodium/bile acid cotransporter

1

1

High-throughput

0.481

High

1460474

FHOD1
FH1/FH2 domain-containing protein 1

1

2

Small-scale

0.481

High

369561

ANGT
Angiotensinogen

1

0

Small-scale

0.480

High

126862

RHOD
Rho-related GTP-binding protein RhoD

1

12

High-throughput

0.479

High

174140

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

2

High-throughput

0.479

High

180099

BET1
BET1 homolog

1

1

High-throughput

0.479

High

189916

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

226253

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

273591

DJC13
DnaJ homolog subfamily C member 13

1

3

High-throughput

0.479

High

341163

DIRA3
GTP-binding protein Di-Ras3

1

2

High-throughput

0.479

High

418504

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.479

High

463827

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.479

High

466515

RHOC
Rho-related GTP-binding protein RhoC

1

7

High-throughput

0.479

High

540740

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

560550

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

562474

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

581363

RAC2
Ras-related C3 botulinum toxin substrate 2

1

7

High-throughput

0.479

High

601487

RHOQ
Rho-related GTP-binding protein RhoQ

1

9

High-throughput

0.479

High

604261

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

630662

RAB3B
Ras-related protein Rab-3B

1

2

High-throughput

0.479

High

868790

LEG7
Galectin-7

1

5

High-throughput

0.479

High

880736

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.479

High

901092

RAB5C
Ras-related protein Rab-5C

1

3

High-throughput

0.479

High

901658

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.479

High

910245

RND2
Rho-related GTP-binding protein RhoN

1

13

High-throughput

0.479

High

945116

RAB25
Ras-related protein Rab-25

1

3

High-throughput

0.479

High

951507

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

953747

RAC3
Ras-related C3 botulinum toxin substrate 3

1

8

High-throughput

0.479

High

955732

CDC42
Cell division control protein 42 homolog

1

9

High-throughput

0.479

High

956535

RAB2A
Ras-related protein Rab-2A

1

3

High-throughput

0.479

High

962614

RHOA
Transforming protein RhoA

1

8

High-throughput

0.479

High

975303

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.479

High

988806

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.479

High

989160

AP2B1
AP-2 complex subunit beta

1

1

High-throughput

0.479

High

1015892

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.479

High

1022987

EFNB1
Ephrin-B1

1

1

High-throughput

0.479

High

1031589

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1041357

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1087334

STX4
Syntaxin-4

1

2

High-throughput

0.479

High

1116104

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.479

High

1145160

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.479

High

1151923

RHOH
Rho-related GTP-binding protein RhoH

1

9

High-throughput

0.479

High

1159896

OCLN
Occludin

1

1

High-throughput

0.479

High

1163824

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

1

High-throughput

0.479

High

1227663

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

1256002

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1271041

RHOU
Rho-related GTP-binding protein RhoU

1

12

High-throughput

0.479

High

1323034

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.479

High

1366905

RND1
Rho-related GTP-binding protein Rho6

1

12

High-throughput

0.479

High

1383155

LRC59
Leucine-rich repeat-containing protein 59

1

5

High-throughput

0.479

High

1395986

DNJC1
DnaJ homolog subfamily C member 1

1

9

High-throughput

0.479

High

1419529

PC11X
Protocadherin-11 X-linked

1

1

High-throughput

0.479

High

1432994

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

1433567

RHOJ
Rho-related GTP-binding protein RhoJ

1

9

High-throughput

0.479

High

1438229

RHOF
Rho-related GTP-binding protein RhoF

1

11

High-throughput

0.479

High

1449988

T106B
Transmembrane protein 106B

1

1

High-throughput

0.479

High

1454795

ANFY1
Rabankyrin-5

1

2

High-throughput

0.479

High

1459228

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1460466

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

1460467

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.479

High

1460470

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

549913

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

High-throughput

0.460

High

718744

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

0

High-throughput

0.460

High

154511

CLD4
Claudin-4

1

0

Small-scale

0.458

High

178433

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

327494

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

575806

MMP9
Matrix metalloproteinase-9

1

0

High-throughput

0.458

High

715835

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

847742

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

1033299

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1229751

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1233557

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1276361

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1341044

THOC2
THO complex subunit 2

1

0

High-throughput

0.458

High

1404271

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1436357

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1450131

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1452723

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1453923

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1460465

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.458

High

641990

CD9
CD9 antigen

1

2

High-throughput

0.445

High

702866

5HT2C
5-hydroxytryptamine receptor 2C

1

3

High-throughput

0.445

High

704092

5HT1E
5-hydroxytryptamine receptor 1E

1

3

High-throughput

0.445

High

1031883

LAT1
Large neutral amino acids transporter small subunit 1

1

2

High-throughput

0.445

High

1273822

NIPA1
Magnesium transporter NIPA1

1

1

High-throughput

0.445

High

1391834

AURKB
Aurora kinase B

1

3

High-throughput

0.445

High

1398017

MF14A
Hippocampus abundant transcript 1 protein

1

2

High-throughput

0.445

High

1404971

S1PR3
Sphingosine 1-phosphate receptor 3

1

3

High-throughput

0.445

High

1420296

S13A1
Solute carrier family 13 member 1

1

1

High-throughput

0.445

High

1439131

ANKH
Mineralization regulator ANKH

1

1

High-throughput

0.445

High

1460469

XCT
Cystine/glutamate transporter

1

2

High-throughput

0.445

High

1460472

FLVC1
Choline/ethanolamine transporter FLVCR1

1

3

High-throughput

0.445

High

1460475

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

1

High-throughput

0.439

High

769457

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

1431286

DJC25
DnaJ homolog subfamily C member 25

1

4

High-throughput

0.437

High

1431786

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.437

High

324232

CE152
Centrosomal protein of 152 kDa

1

0

High-throughput

0.426

High

388467

B3AT
Band 3 anion transport protein

1

0

High-throughput

0.426

High

889036

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.426

High

1307978

EPHX4
Epoxide hydrolase 4

1

0

High-throughput

0.426

High

1326138

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

73865

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

1

High-throughput

0.407

High

1379889

FATE1
Fetal and adult testis-expressed transcript protein

3

0

High-throughput

0.352

High

1362534

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

0

High-throughput

0.328

High

1198913

NACHO
Novel acetylcholine receptor chaperone

2

0

High-throughput

0.316

High

1434961

REEP4
Receptor expression-enhancing protein 4

2

0

High-throughput

0.316

High

587249

ITF2
Transcription factor 4

1

0

High-throughput

0.299

High

1204566

NMS
Neuromedin-S

1

0

High-throughput

0.279

Low

1278647

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1281718

B3GN8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

1

0

High-throughput

0.279

Low

1350909

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1367963

TF2H4
General transcription factor IIH subunit 4

1

0

High-throughput

0.279

Low

1102468

BIK
Bcl-2-interacting killer

1

0

High-throughput

0.251

Low

140024

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

1293194

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1381994

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1258287

SAMC
Mitochondrial S-adenosylmethionine carrier protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025