HitPredict

Interactor 1: NPRL3 (Q12980)
GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA)
Gene: NPRL3

Interactor 2: WDR59 (Q6PJI9)
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)
Gene: WDR59

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	28199306, 35831510, 25263562
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005765 - lysosomal membrane GO:0034198 - cellular response to amino acid starvation GO:1904262 - negative regulation of TORC1 signaling
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 569 Hs			1 974
+	Hs
		1021881 NPRL3_HUMAN (1-569): 0: 789: 100.00		WDR24_HUMAN (3-165): 3.25e-20: 98.7: 12.79
+	Dm
		1372306 NPRL3_DROME (1-562): 0: 654: 36.57		MIO_DROME (21-223): 2.65e-20: 99.1: 9.57
+	Dm
		1197150 NPRL3_DROME (1-562): 0: 654: 36.57		Q86BR7_DROME (3-131): 8.58e-20: 97.2: 14.39
+	Dm
		1374304 NPRL3_DROME (1-562): 0: 654: 36.57		WDR24_DROME (3-131): 7.53e-20: 97.2: 14.39
+	Sp
		142471 NPRL3_SCHPO (8-552): 0: 539: 21.70		WDR59_SCHPO (12-234): 2.62e-23: 109: 13.82