HitPredict

Interactor 1: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Interactor 2: DBLOH (Q9NR28)
Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspases) (SMAC) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]
Gene: DIABLO

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 27476169, 28514442, 11140638, 12660240, 31699976, 10929712, 32877691, 32447208, 33961781, 34247143, 35941108, 15541727, 14523016, 20957035, 15507451, 11242052, 14512414, 12218061, 25246529, 15300255 and 33 others

more...
Identification Methods affinity chromatography technology, x-ray crystallography, pull down, proximity labelling technology, far western blotting, enzymatic study, unspecified method, anti tag coimmunoprecipitation, surface plasmon resonance, fluorescence polarization spectroscopy
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains BIR~Smac_DIABLO
Common GO terms GO:0005829 - cytosol
GO:0051402 - neuron apoptotic process
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 497
Hs

1 239
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Last updated: 11Aug2025