HitPredict

Interactor 1: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Interactor 2: DBLOH (Q9NR28)
Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspases) (SMAC) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]
Gene: DIABLO

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.988

The method score is based on:

Property Details
Experiments 27476169, 28514442, 10929712, 33961781, 35941108, 16282325, 20957035, 12218061, 25246529, 12865429, 30359437, 35027744, 14960576, 12525502, 19506082, 19153467, 25065467, 11606597, unassigned3799
Identification Methods affinity chromatography technology, pull down, enzymatic study, x-ray crystallography, unspecified method, anti tag coimmunoprecipitation, coimmunoprecipitation, surface plasmon resonance
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains BIR~Smac_DIABLO
Common GO terms GO:0005829 - cytosol
GO:0006915 - apoptotic process
GO:0009898 - cytoplasmic side of plasma membrane
GO:0035631 - CD40 receptor complex
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 618
Hs

1 239
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
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+ Rn
+ Hs

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Last updated: 11Aug2025