HitPredict

Interactor 1: STK4 (Q13043)
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Gene: STK4

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30673917
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 487 Hs			1 522
+	Mm
		682105 AKT1_MOUSE (3-350): 2.1e-132: 393: 20.89		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		610801 KAPCB_HUMAN (14-319): 8.38e-123: 364: 25.63		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		1350188 STK26_HUMAN (25-390): 1.4e-119: 358: 43.82		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Mm
		936271 STK26_MOUSE (25-303): 2.37e-118: 355: 52.65		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		1356425 TNIK_HUMAN (8-309): 2.1e-73: 254: 44.80		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		616728 KS6B1_HUMAN (20-440): 2.22e-130: 390: 20.68		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		1023648 STK3_HUMAN (1-487): 2.36e-147: 432: 72.47		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		610720 KAPCB_HUMAN (14-319): 8.38e-123: 364: 25.63		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		1018149 M4K2_HUMAN (17-316): 3.72e-75: 254: 42.67		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1020980 TNIK_HUMAN (8-309): 2.1e-73: 254: 44.80		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1021001 M4K5_HUMAN (20-318): 7.15e-75: 253: 44.30		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Mm
		761826 M4K5_MOUSE (20-318): 3.7e-74: 251: 44.30		TRAF2_MOUSE (40-500): 3.02e-101: 315: 26.05
+	Hs
		131546 STK25_HUMAN (14-327): 8.86e-120: 359: 48.74		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		537109 STK26_HUMAN (25-390): 1.4e-119: 358: 43.82		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		536810 PAK1_HUMAN (3-305): 1.66e-117: 357: 40.91		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Dm
		1182619 Q7KV89_DROME (17-337): 2.42e-72: 249: 42.27		Q9XYR0_DROME (130-500): 4.19e-66: 223: 22.49
+	Hs
		1183122 MARK2_HUMAN (6-486): 9.18e-123: 378: 20.68		RNF41_HUMAN (55-177): 2.33e-17: 84.9: 33.33
+	Hs
		1163009 M4K3_HUMAN (20-344): 2.76e-114: 359: 42.47		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26
+	Hs
		537127 TNIK_HUMAN (8-309): 2.1e-73: 254: 44.80		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1163057 M4K5_HUMAN (20-318): 7.15e-75: 253: 44.30		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26