Protein: SPF45
Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17)

Gene: SPF45, RBM17
Organism: Homo sapiens
Interactions: 200
UniProt ID: Q96I25

Gene Ontology (top 5):
GO:0000380 - alternative mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex
GO:0045292 - mRNA cis splicing, via spliceosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

286032

SF3B1
Splicing factor 3B subunit 1

7

7

Small-scale

0.971

High

175757

SR140
U2 snRNP-associated SURP motif-containing protein

7

12

High-throughput

0.965

High

207620

DHX15
ATP-dependent RNA helicase DHX15

6

11

High-throughput

0.956

High

1150794

SF01
Splicing factor 1

5

11

Small-scale

0.925

High

1088725

SF3A3
Splicing factor 3A subunit 3

4

2

High-throughput

0.903

High

1148638

SF3A2
Splicing factor 3A subunit 2

4

6

Small-scale

0.895

High

485713

RU2A
U2 small nuclear ribonucleoprotein A'

4

5

High-throughput

0.892

High

1152344

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

4

11

High-throughput

0.892

High

1105376

SF3B2
Splicing factor 3B subunit 2

3

3

High-throughput

0.871

High

913978

RBM5
RNA-binding protein 5

3

20

High-throughput

0.855

High

471901

RU2B
U2 small nuclear ribonucleoprotein B''

2

20

High-throughput

0.811

High

1023147

RBM10
RNA-binding protein 10

2

20

High-throughput

0.776

High

1148539

SF3B4
Splicing factor 3B subunit 4

2

16

High-throughput

0.776

High

1294104

DDX42
ATP-dependent RNA helicase DDX42

2

13

High-throughput

0.776

High

1394010

LN28A
Protein lin-28 homolog A

2

6

High-throughput

0.776

High

1152325

U2AFL
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1

2

11

High-throughput

0.712

High

997942

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.710

High

1149161

SF3A1
Splicing factor 3A subunit 1

4

9

High-throughput

0.699

High

1311267

CHERP
Calcium homeostasis endoplasmic reticulum protein

4

18

High-throughput

0.697

High

576502

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

19

High-throughput

0.691

High

658341

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.691

High

890561

RBP2
E3 SUMO-protein ligase RanBP2

1

5

High-throughput

0.691

High

1006625

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.691

High

1062595

DHX9
ATP-dependent RNA helicase A

1

12

High-throughput

0.691

High

1148005

SF3B3
Splicing factor 3B subunit 3

1

5

High-throughput

0.691

High

1394013

DDX21
Nucleolar RNA helicase 2

1

18

High-throughput

0.691

High

1351858

NEK7
Serine/threonine-protein kinase Nek7

1

3

High-throughput

0.665

High

1088282

SFSWA
Splicing factor, suppressor of white-apricot homolog

3

10

High-throughput

0.662

High

1063524

GOGA2
Golgin subfamily A member 2

5

6

High-throughput

0.657

High

1350693

CCHCR
Coiled-coil alpha-helical rod protein 1

5

6

High-throughput

0.654

High

685686

U2AF2
Splicing factor U2AF 65 kDa subunit

1

17

Small-scale

0.647

High

1311556

SUGP1
SURP and G-patch domain-containing protein 1

2

16

High-throughput

0.644

High

974015

RUXF
Small nuclear ribonucleoprotein F

2

7

High-throughput

0.628

High

211389

RFOX2
RNA binding protein fox-1 homolog 2

1

18

High-throughput

0.621

High

909134

NEK4
Serine/threonine-protein kinase Nek4

1

3

High-throughput

0.618

High

1394023

SRPK3
SRSF protein kinase 3

1

20

High-throughput

0.618

High

173229

XPO1
Exportin-1

1

5

High-throughput

0.618

High

472985

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

18

High-throughput

0.618

High

650909

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

20

Small-scale

0.618

High

667984

CDK2
Cyclin-dependent kinase 2

1

5

High-throughput

0.618

High

775260

FUS
RNA-binding protein FUS

1

20

High-throughput

0.618

High

1088506

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

11

High-throughput

0.618

High

1118124

DX39B
Spliceosome RNA helicase DDX39B

1

15

High-throughput

0.618

High

1128086

DHX8
ATP-dependent RNA helicase DHX8

1

11

High-throughput

0.618

High

1132892

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

11

High-throughput

0.618

High

1290111

THOC4
THO complex subunit 4

1

12

High-throughput

0.618

High

1368567

KAT6A
Histone acetyltransferase KAT6A

1

12

High-throughput

0.618

High

1368860

RBP56
TATA-binding protein-associated factor 2N

1

12

High-throughput

0.618

High

1393999

DDX23
Probable ATP-dependent RNA helicase DDX23

1

18

High-throughput

0.618

High

1394017

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.618

High

1394022

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

5

High-throughput

0.618

High

1394002

PP12C
Protein phosphatase 1 regulatory subunit 12C

3

3

High-throughput

0.616

High

1331521

GPT11
G patch domain-containing protein 11

3

2

High-throughput

0.616

High

1393994

CDC5L
Cell division cycle 5-like protein

2

4

High-throughput

0.611

High

1311711

CCAR1
Cell division cycle and apoptosis regulator protein 1

2

5

High-throughput

0.601

High

1393992

WDFY2
WD repeat and FYVE domain-containing protein 2

3

7

High-throughput

0.593

High

223254

PRC1
Protein regulator of cytokinesis 1

2

2

High-throughput

0.586

High

129330

MEN1
Menin

2

1

High-throughput

0.584

High

1129697

MDC1
Mediator of DNA damage checkpoint protein 1

2

10

Small-scale

0.584

High

269343

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1393991

RNPC3
RNA-binding region-containing protein 3

1

12

High-throughput

0.575

High

1394019

DDX41
Probable ATP-dependent RNA helicase DDX41

1

15

High-throughput

0.575

High

977796

ACTA
Actin, aortic smooth muscle

2

8

High-throughput

0.574

High

1180175

QRIC1
Transcriptional regulator QRICH1

2

2

High-throughput

0.573

High

1315519

CC170
Coiled-coil domain-containing protein 170

2

3

High-throughput

0.553

High

157733

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.553

High

349202

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.553

High

401303

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.553

High

1181239

MYLK3
Myosin light chain kinase 3

1

1

High-throughput

0.553

High

1316961

FAM9B
Protein FAM9B

1

0

High-throughput

0.549

High

212306

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

2

High-throughput

0.536

High

215169

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

5

High-throughput

0.536

High

257935

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

1

High-throughput

0.536

High

298429

DNJC8
DnaJ homolog subfamily C member 8

1

6

High-throughput

0.536

High

301166

RL1D1
Ribosomal L1 domain-containing protein 1

1

3

High-throughput

0.536

High

586829

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.536

High

593864

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

4

High-throughput

0.536

High

809781

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.536

High

842488

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

854226

KI67
Proliferation marker protein Ki-67

1

8

High-throughput

0.536

High

860886

RS10
Small ribosomal subunit protein eS10

1

1

High-throughput

0.536

High

935600

MFAP1
Microfibrillar-associated protein 1

1

3

High-throughput

0.536

High

973795

RUXE
Small nuclear ribonucleoprotein E

1

2

High-throughput

0.536

High

974182

RUXG
Small nuclear ribonucleoprotein G

1

13

High-throughput

0.536

High

974448

SMD1
Small nuclear ribonucleoprotein Sm D1

1

9

High-throughput

0.536

High

974640

SMD2
Small nuclear ribonucleoprotein Sm D2

1

3

High-throughput

0.536

High

1111195

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.536

High

1113995

CUL3
Cullin-3

1

10

High-throughput

0.536

High

1231221

KDM4D
Lysine-specific demethylase 4D

1

1

High-throughput

0.536

High

1358924

PCNP
PEST proteolytic signal-containing nuclear protein

1

1

High-throughput

0.536

High

1394000

GNL3
Guanine nucleotide-binding protein-like 3

1

1

High-throughput

0.536

High

927488

ATX1
Ataxin-1

1

4

Small-scale

0.529

High

1394005

IQCN
IQ domain-containing protein N

1

1

High-throughput

0.523

High

463195

YES
Tyrosine-protein kinase Yes

2

3

High-throughput

0.521

High

593780

PECA1
Platelet endothelial cell adhesion molecule

1

6

High-throughput

0.515

High

697990

CALR
Calreticulin

1

4

High-throughput

0.515

High

788146

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.515

High

123803

MYO1C
Unconventional myosin-Ic

1

0

High-throughput

0.513

High

219998

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

1328838

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.513

High

1393997

TRIR
Telomerase RNA component interacting RNase

1

0

High-throughput

0.513

High

1394016

CWC15
Spliceosome-associated protein CWC15 homolog

1

1

High-throughput

0.508

High

1394018

S30BP
SAP30-binding protein

1

3

High-throughput

0.508

High

127164

APBB1
Amyloid beta precursor protein binding family B member 1

1

2

High-throughput

0.501

High

185935

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.501

High

1136317

EMC2
ER membrane protein complex subunit 2

1

5

High-throughput

0.489

High

1201032

ACTBL
Beta-actin-like protein 2

1

8

High-throughput

0.489

High

1384102

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.489

High

1393998

HINFP
Histone H4 transcription factor

1

2

Small-scale

0.481

High

260305

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

331238

KI20A
Kinesin-like protein KIF20A

1

11

High-throughput

0.479

High

346195

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

12

High-throughput

0.479

High

350108

SNAI1
Zinc finger protein SNAI1

1

3

High-throughput

0.479

High

372848

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

406507

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

520290

ANDR
Androgen receptor

1

12

High-throughput

0.479

High

537710

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

589416

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

696216

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

764964

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

768895

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

786781

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.479

High

831245

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

905033

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.479

High

937852

FOXA1
Hepatocyte nuclear factor 3-alpha

1

5

High-throughput

0.479

High

980142

H4
Histone H4

1

4

High-throughput

0.479

High

995196

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.479

High

998679

H31
Histone H3.1

1

6

High-throughput

0.479

High

1024765

VIGLN
Vigilin

1

20

High-throughput

0.479

High

1033747

PO5F1
POU domain, class 5, transcription factor 1

1

3

High-throughput

0.479

High

1035846

KIF23
Kinesin-like protein KIF23

1

8

High-throughput

0.479

High

1045642

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

1067603

EP300
Histone acetyltransferase p300

1

7

High-throughput

0.479

High

1096788

RFA4
Replication protein A 30 kDa subunit

1

8

High-throughput

0.479

High

1137940

TNIP1
TNFAIP3-interacting protein 1

1

10

High-throughput

0.479

High

1146773

PCBP1
Poly(rC)-binding protein 1

1

20

High-throughput

0.479

High

1151174

OASL
2'-5'-oligoadenylate synthase-like protein

1

3

High-throughput

0.479

High

1271200

DPPA4
Developmental pluripotency-associated protein 4

1

1

High-throughput

0.479

High

1289537

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1290651

ZCH18
Zinc finger CCCH domain-containing protein 18

1

8

High-throughput

0.479

High

1313334

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

1346890

SNIP1
Smad nuclear-interacting protein 1

1

3

High-throughput

0.479

High

1367019

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

1387491

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

11

High-throughput

0.479

High

1393993

CIC
Protein capicua homolog

1

11

High-throughput

0.479

High

1393995

BARD1
BRCA1-associated RING domain protein 1

1

7

High-throughput

0.479

High

1393996

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1394003

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

1394008

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

1394009

NANOG
Homeobox protein NANOG

1

2

High-throughput

0.479

High

1394011

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

3

High-throughput

0.479

High

1394014

RNC
Ribonuclease 3

1

3

High-throughput

0.479

High

1394021

FZR1
Fizzy-related protein homolog

1

12

High-throughput

0.479

High

1394024

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.479

High

1390519

CDCA5
Sororin

1

0

High-throughput

0.458

High

1394012

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1394015

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1228515

TENS3
Tensin-3

1

1

High-throughput

0.457

High

430241

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

765798

BMI1
Polycomb complex protein BMI-1

1

7

High-throughput

0.445

High

1029135

E2F1
Transcription factor E2F1

1

3

High-throughput

0.445

High

1119253

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

132235

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.437

High

242588

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.437

High

272388

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.437

High

294176

CD123
Translation initiation factor eIF2 assembly protein

1

5

High-throughput

0.437

High

319979

UFL1
E3 UFM1-protein ligase 1

1

3

High-throughput

0.437

High

970927

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.437

High

995766

ACTC
Actin, alpha cardiac muscle 1

1

7

High-throughput

0.437

High

1120488

SCRB2
Lysosome membrane protein 2

1

1

High-throughput

0.437

High

1140693

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.437

High

1246930

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.437

High

1255072

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1393596

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

1394007

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

1394020

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

High-throughput

0.437

High

1394025

MB212
Protein mab-21-like 2

1

1

High-throughput

0.437

High

1308828

P3H2
Prolyl 3-hydroxylase 2

1

0

High-throughput

0.426

High

887121

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

97161

E9PQQ4
Heat shock protein family A

1

8

High-throughput

0.407

High

159253

ABLM1
Actin-binding LIM protein 1

1

1

High-throughput

0.407

High

1155089

UT2
Urea transporter 2

1

1

High-throughput

0.407

High

1203225

ODFP2
Outer dense fiber protein 2

1

1

High-throughput

0.407

High

1244711

TTC33
Tetratricopeptide repeat protein 33

1

6

High-throughput

0.407

High

1325435

SYNPO
Synaptopodin

1

9

High-throughput

0.407

High

639635

SAT1
Diamine acetyltransferase 1

6

0

High-throughput

0.385

High

1198496

CEP55
Centrosomal protein of 55 kDa

4

0

High-throughput

0.364

High

1278356

COMD6
COMM domain-containing protein 6

1

0

High-throughput

0.279

Low

1293496

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.279

Low

1326874

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

1394004

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.279

Low

301632

WFS1
Wolframin

1

0

High-throughput

0.268

Low

350556

CF047
Uncharacterized protein C6orf47

1

0

High-throughput

0.261

Low

1325753

LNX2
Ligand of Numb protein X 2

1

0

High-throughput

0.251

Low

257491

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

516778

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.249

Low

1360113

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.249

Low

1394006

TOLIP
Toll-interacting protein

1

0

High-throughput

0.249

Low

1132412

CASP8
Caspase-8

1

0

High-throughput

0.232

Low

1394001

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025