HitPredict

Interactor 1: TRAF3 (Q13114)
TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)
Gene: TRAF3

Interactor 2: DHX58 (Q96C10)
ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR)
Gene: DHX58

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29661858
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008270 - zinc ion binding GO:0032481 - positive regulation of type I interferon production
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 568 Hs			1 678
+	Hs
		129586 TRAF5_HUMAN (12-567): 9.32e-132: 397: 40.79		DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00
+	Hs
		321891 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89
+	Hs
		1020856 TRAF2_HUMAN (11-565): 1.77e-110: 340: 30.21		DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00
+	Mm
		1111925 TRAF3_MOUSE (1-568): 3.65e-163: 478: 96.13		SMCA4_MOUSE (3-592): 1.63e-74: 264: 12.94
+	Hs
		1286224 TRAF6_HUMAN (22-562): 7.2e-84: 272: 21.28		DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00
+	Hs
		134011 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Mm
		761822 TRAF2_MOUSE (25-565): 3.06e-110: 340: 31.16		RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88
+	Mm
		1163172 TRI11_MOUSE (41-480): 1.77e-49: 179: 9.11		RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88
+	Hs
		321932 TRIM6_HUMAN (39-480): 3.76e-49: 179: 10.99		RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89
+	Hs
		134263 TRAF6_HUMAN (22-562): 7.2e-84: 272: 21.28		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Hs
		134009 TRAF1_HUMAN (151-563): 2.25e-80: 260: 32.63		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Hs
		536834 TRI27_HUMAN (40-481): 5.22e-53: 190: 11.37		CHD4_HUMAN (2-626): 2.02e-73: 260: 12.48
+	Hs
		1271706 TRAF6_HUMAN (22-562): 7.2e-84: 272: 21.28		DDX17_HUMAN (2-260): 1.9e-42: 165: 17.23
+	Hs
		536917 TRI27_HUMAN (40-481): 5.22e-53: 190: 11.37		FANCM_HUMAN (4-542): 6.34e-65: 235: 17.68
+	Hs
		571424 TRAF1_HUMAN (151-563): 2.25e-80: 260: 32.63		DDX5_HUMAN (2-255): 1.99e-37: 150: 15.21
+	Hs
		134128 TRI58_HUMAN (45-481): 4.03e-54: 192: 9.76		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Hs
		134038 TRI25_HUMAN (46-374): 4.38e-42: 162: 16.08		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Hs
		536749 TRI27_HUMAN (40-481): 5.22e-53: 190: 11.37		IF4A3_HUMAN (2-345): 5e-28: 118: 8.96
+	Dm
		580736 Q960H6_DROME (161-560): 1.1e-53: 190: 19.56		DDX17_DROME (335-500): 7.82e-16: 83.3: 22.16
+	Dm
		580763 Q9VXG5_DROME (191-560): 1.45e-50: 180: 19.29		DDX17_DROME (335-500): 7.82e-16: 83.3: 22.16