HitPredict

Interactor 1: TRAF3 (Q13114)
TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)
Gene: TRAF3

Interactor 2: TNR11 (Q9Y6Q6)
Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265)
Gene: TNFRSF11A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	9852070, 10025951, 9774460
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0033209 - tumor necrosis factor-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 568 Hs			1 616
+	Mm
		192587 TRAF3_MOUSE (1-568): 3.65e-163: 478: 96.13		TNR11_MOUSE (1-615): 0: 833: 67.20
+	Mm
		192584 TRAF5_MOUSE (10-567): 4.83e-133: 401: 41.36		TNR11_MOUSE (1-615): 0: 833: 67.20
+	Mm
		648958 TRAF3_MOUSE (1-568): 3.65e-163: 478: 96.13		TNR5_MOUSE (11-226): 6.73e-70: 229: 33.03
+	Hs
		639578 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR5_HUMAN (11-227): 5.79e-69: 226: 36.07
+	Hs
		738661 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR3_HUMAN (1-208): 4.39e-57: 200: 26.01
+	Hs
		591320 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR1B_HUMAN (1-213): 2.29e-52: 188: 31.86
+	Hs
		1024725 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR14_HUMAN (7-190): 2.49e-51: 180: 29.10
+	Mm
		838553 TRAF3_MOUSE (1-568): 3.65e-163: 478: 96.13		TNR3_MOUSE (33-200): 4.66e-49: 178: 27.01
+	Hs
		584394 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR1A_HUMAN (33-236): 3.5e-47: 173: 21.91
+	Hs
		436620 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR16_HUMAN (25-212): 8.51e-42: 158: 23.96
+	Mm
		812913 TRAF3_MOUSE (1-568): 3.65e-163: 478: 96.13		TNR4_MOUSE (34-217): 5.48e-43: 157: 24.46
+	Hs
		796825 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR4_HUMAN (29-217): 5.17e-39: 146: 26.46
+	Hs
		1024793 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR18_HUMAN (86-233): 2.45e-37: 140: 24.16
+	Hs
		632265 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR6_HUMAN (24-153): 8.97e-36: 139: 25.56
+	Hs
		989744 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR9_HUMAN (47-227): 1.18e-34: 133: 25.93
+	Hs
		1024787 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		EDAR_HUMAN (16-237): 4.36e-32: 131: 18.18
+	Mm
		591448 TRAF3_MOUSE (1-568): 3.65e-163: 478: 96.13		TNR9_MOUSE (45-211): 4.13e-32: 126: 27.98
+	Hs
		661045 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR8_HUMAN (30-192): 6.05e-25: 111: 25.00
+	Hs
		645797 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		CD27_HUMAN (17-130): 6.72e-26: 109: 26.27
+	Hs
		1024763 TRAF3_HUMAN (1-568): 1.45e-163: 479: 100.00		TNR27_HUMAN (33-153): 6.46e-25: 107: 23.88