HitPredict

Interactor 1: REST (Q13127)
RE1-silencing transcription factor (Neural-restrictive silencer factor) (X2 box repressor)
Gene: REST

Interactor 2: FBW1B (Q9UKB1)
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Gene: FBXW11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.742

Property	Details
Experiments	25332235, 25900982, 25515538, 18354482, 22017875, 24500709, 18354483
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1097 Hs			1 542
+	Hs
		1025094 REST_HUMAN (1-1097): 0: 670: 100.00		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		1025056 REST_HUMAN (1-1097): 0: 670: 100.00		FBXW7_HUMAN (18-424): 1.12e-72: 246: 20.29
+	Hs
		1025088 REST_HUMAN (1-1097): 0: 670: 100.00		FBXW2_HUMAN (357-517): 4.14e-24: 106: 27.59
+	Hs
		1281490 ZN510_HUMAN (157-336): 7.24e-16: 84.7: 30.56		FBXW7_HUMAN (18-424): 1.12e-72: 246: 20.29