HitPredict

Interactor 1: CACO2 (Q13137)
Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52)
Gene: CALCOCO2

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	33815386, 21988832
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 446 Hs			1 522
+	Hs
		1201953 TAXB1_HUMAN (13-437): 1.11e-40: 156: 21.87		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Mm
		936226 TAXB1_MOUSE (13-439): 3.84e-36: 143: 21.23		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		1020633 CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1025532 CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		1024665 CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Mm
		761811 TAXB1_MOUSE (13-439): 3.84e-36: 143: 21.23		TRAF2_MOUSE (40-500): 3.02e-101: 315: 26.05
+	Hs
		1201894 TAXB1_HUMAN (13-437): 1.11e-40: 156: 21.87		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		1024703 TAXB1_HUMAN (13-437): 1.11e-40: 156: 21.87		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Mm
		1141401 EP15R_MOUSE (102-435): 2.36e-31: 129: 13.55		TRAF3_MOUSE (20-501): 4.18e-85: 275: 22.40
+	Hs
		584942 CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		787905 EPS15_HUMAN (77-234): 4.48e-10: 64: 11.88		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1025546 CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		969614 CENPE_HUMAN (124-345): 3.98e-10: 64.4: 21.34		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		585002 TAXB1_HUMAN (13-437): 1.11e-40: 156: 21.87		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		1025470 CACO2_HUMAN (1-446): 3.19e-64: 215: 100.00		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84
+	Hs
		301939 DLG5_HUMAN (77-439): 7.24e-18: 88.6: 10.03		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		301757 MAP1A_HUMAN (159-425): 1.97e-12: 71.7: 12.64		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		301948 MY18A_HUMAN (127-365): 3.21e-10: 64.8: 15.81		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		1201849 TAXB1_HUMAN (13-437): 1.11e-40: 156: 21.87		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84
+	Hs
		528393 MYH6_HUMAN (94-439): 7.55e-10: 63.6: 12.78		TRIM6_HUMAN (56-403): 5.03e-39: 150: 12.97