Protein: KCD17
BTB/POZ domain-containing protein KCTD17

Gene: KCD17, KCTD17
Organism: Homo sapiens
Interactions: 184
UniProt ID: Q8N5Z5

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0030030 - cell projection organization
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0032469 - endoplasmic reticulum calcium ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1113692

CUL3
Cullin-3

11

20

Small-scale

0.977

High

1130012

KCTD2
BTB/POZ domain-containing protein KCTD2

5

15

Small-scale

0.919

High

1328682

KCTD5
BTB/POZ domain-containing protein KCTD5

5

15

Small-scale

0.919

High

1328639

KCD17
BTB/POZ domain-containing protein KCTD17

2

18

Small-scale

0.822

High

1328683

KCND2
A-type voltage-gated potassium channel KCND2

2

17

High-throughput

0.811

High

291839

STK16
Serine/threonine-protein kinase 16

4

5

High-throughput

0.705

High

1328684

KLHL8
Kelch-like protein 8

1

4

High-throughput

0.691

High

1217540

MRCKA
Serine/threonine-protein kinase MRCK alpha

4

11

High-throughput

0.691

High

1257790

ACD11
Acyl-CoA dehydrogenase family member 11

4

3

High-throughput

0.691

High

1327825

ARRD1
Arrestin domain-containing protein 1

4

4

High-throughput

0.691

High

315775

RECQ4
ATP-dependent DNA helicase Q4

3

11

High-throughput

0.667

High

708858

PTN4
Tyrosine-protein phosphatase non-receptor type 4

3

20

High-throughput

0.667

High

944829

PCBP3
Poly(rC)-binding protein 3

3

8

High-throughput

0.667

High

1328646

CERK1
Ceramide kinase

3

1

High-throughput

0.667

High

1328657

RBM14
RNA-binding protein 14

3

7

High-throughput

0.667

High

1328659

MTMR9
Myotubularin-related protein 9

3

5

High-throughput

0.667

High

1328695

NEB1
Neurabin-1

3

20

High-throughput

0.667

High

1328696

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

3

1

High-throughput

0.667

High

1328700

MTMR6
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

3

5

High-throughput

0.667

High

1328656

FRMD6
FERM domain-containing protein 6

3

20

High-throughput

0.650

High

129771

CBX4
E3 SUMO-protein ligase CBX4

4

4

High-throughput

0.630

High

134336

RPOM
DNA-directed RNA polymerase, mitochondrial

4

2

High-throughput

0.630

High

1103778

PLD1
Phospholipase D1

4

1

High-throughput

0.630

High

1328661

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

4

2

High-throughput

0.630

High

1328685

POLK
DNA polymerase kappa

4

2

High-throughput

0.630

High

228916

CF410
Cilia- and flagella-associated protein 410

2

20

High-throughput

0.611

High

877172

KC1D
Casein kinase I isoform delta

2

8

High-throughput

0.611

High

1128179

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

3

1

High-throughput

0.609

High

658526

GLRA2
Glycine receptor subunit alpha-2

3

5

High-throughput

0.609

High

1328666

REPI1
DNA-binding protein REPIN1

3

2

High-throughput

0.609

High

1328644

LNX1
E3 ubiquitin-protein ligase LNX

2

20

High-throughput

0.608

High

222146

NCK2
Cytoplasmic protein NCK2

2

20

High-throughput

0.606

High

334439

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

3

High-throughput

0.606

High

890666

RGS3
Regulator of G-protein signaling 3

3

10

High-throughput

0.604

High

1328660

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

3

1

High-throughput

0.593

High

844829

EAA1
Excitatory amino acid transporter 1

3

7

High-throughput

0.587

High

1328642

MPLKI
M-phase-specific PLK1-interacting protein

2

0

High-throughput

0.585

High

983531

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

2

14

Small-scale

0.584

High

599299

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

2

3

High-throughput

0.576

High

855686

CRK
Adapter molecule crk

2

20

High-throughput

0.576

High

1328643

RIN3
Ras and Rab interactor 3

2

11

High-throughput

0.576

High

1328658

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

2

4

High-throughput

0.574

High

1328677

C1QR1
Complement component C1q receptor

2

8

High-throughput

0.574

High

1328670

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

1

High-throughput

0.573

High

983886

RBX1
E3 ubiquitin-protein ligase RBX1

1

6

Small-scale

0.561

High

948073

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

2

10

Small-scale

0.558

High

1201739

NADL2
Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2

2

1

High-throughput

0.558

High

1212227

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

20

High-throughput

0.558

High

1328673

ZN696
Zinc finger protein 696

2

1

High-throughput

0.558

High

1328645

O51E1
Olfactory receptor 51E1

2

1

High-throughput

0.553

High

548061

PSPC
Surfactant protein C

2

2

High-throughput

0.549

High

1150451

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

20

High-throughput

0.549

High

1328693

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

2

10

High-throughput

0.549

High

680950

PSA1
Proteasome subunit alpha type-1

1

13

High-throughput

0.541

High

715930

AQP1
Aquaporin-1

1

2

High-throughput

0.541

High

1325780

LRC18
Leucine-rich repeat-containing protein 18

1

19

High-throughput

0.541

High

1328668

NIF3L
NIF3-like protein 1

1

2

High-throughput

0.541

High

1328663

TCHP
Trichoplein keratin filament-binding protein

1

13

Small-scale

0.536

High

50372

PXDNL
Probable oxidoreductase PXDNL

1

5

High-throughput

0.536

High

275841

GLRA3
Glycine receptor subunit alpha-3

1

5

High-throughput

0.536

High

300193

GLRX3
Glutaredoxin-3

1

10

High-throughput

0.536

High

624094

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

14

High-throughput

0.536

High

1328653

OPTN
Optineurin

1

20

High-throughput

0.536

High

1328667

NLRP1
NACHT, LRR and PYD domains-containing protein 1

1

1

High-throughput

0.536

High

1328704

MRCKB
Serine/threonine-protein kinase MRCK beta

1

12

High-throughput

0.536

High

1024103

TFAM
Transcription factor A, mitochondrial

2

3

High-throughput

0.521

High

130988

HIP1
Huntingtin-interacting protein 1

1

16

High-throughput

0.515

High

216751

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.515

High

390105

ALBU
Albumin

1

1

High-throughput

0.515

High

442403

GELS
Gelsolin

1

4

High-throughput

0.515

High

637633

FLNA
Filamin-A

1

20

High-throughput

0.515

High

650296

FGFR3
Fibroblast growth factor receptor 3

1

9

High-throughput

0.515

High

656189

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

4

High-throughput

0.515

High

702479

CLAT
Choline O-acetyltransferase

1

1

High-throughput

0.515

High

833313

PERI
Peripherin

1

19

High-throughput

0.515

High

843767

HD
Huntingtin

1

3

High-throughput

0.515

High

930994

HSP72
Heat shock-related 70 kDa protein 2

1

20

High-throughput

0.515

High

966613

1433G
14-3-3 protein gamma

1

20

High-throughput

0.515

High

981587

RAN
GTP-binding nuclear protein Ran

1

9

High-throughput

0.515

High

986567

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

High-throughput

0.515

High

988527

RAC1
Ras-related C3 botulinum toxin substrate 1

1

10

High-throughput

0.515

High

1139763

SETB1
Histone-lysine N-methyltransferase SETDB1

1

4

High-throughput

0.515

High

1157466

PKN1
Serine/threonine-protein kinase N1

1

9

High-throughput

0.515

High

1328641

LMO3
LIM domain only protein 3

1

7

High-throughput

0.515

High

1328648

APBB2
Amyloid beta precursor protein binding family B member 2

1

1

High-throughput

0.515

High

1328649

KAT5
Histone acetyltransferase KAT5

1

2

High-throughput

0.515

High

1328698

UBQL1
Ubiquilin-1

1

2

High-throughput

0.515

High

1328701

SHLB1
Endophilin-B1

1

20

High-throughput

0.515

High

1197642

MIDN
Midnolin

1

0

High-throughput

0.513

High

1234696

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

1

0

High-throughput

0.513

High

1239112

RWDD4
RWD domain-containing protein 4

1

2

High-throughput

0.494

High

1256869

NUD18
8-oxo-dGDP phosphatase NUDT18

1

2

High-throughput

0.494

High

937063

CASP6
Caspase-6

1

0

High-throughput

0.493

High

766104

PCGF2
Polycomb group RING finger protein 2

1

5

High-throughput

0.489

High

893557

GBG4

1

10

High-throughput

0.489

High

1013418

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

2

High-throughput

0.489

High

1032018

TFAP4
Transcription factor AP-4

1

1

High-throughput

0.489

High

1149935

TERF2
Telomeric repeat-binding factor 2

1

3

High-throughput

0.489

High

1206944

CEP78
Centrosomal protein of 78 kDa

1

4

High-throughput

0.489

High

1280953

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

1

High-throughput

0.489

High

1312460

PHC2
Polyhomeotic-like protein 2

1

6

High-throughput

0.489

High

1316034

TRM2A
tRNA

1

1

High-throughput

0.489

High

1328640

ZN579
Zinc finger protein 579

1

1

High-throughput

0.489

High

1328669

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

1

10

High-throughput

0.489

High

1328681

TM45A
Transmembrane protein 45A

1

2

High-throughput

0.489

High

1328699

TRI33
E3 ubiquitin-protein ligase TRIM33

1

13

High-throughput

0.489

High

906705

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

0

Small-scale

0.480

High

257482

PAGE4
P antigen family member 4

1

2

High-throughput

0.479

High

294018

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

319905

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

396511

ESR1
Estrogen receptor

1

9

High-throughput

0.479

High

414206

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

447220

NPM
Nucleophosmin

1

5

High-throughput

0.479

High

482511

F16P1
Fructose-1,6-bisphosphatase 1

1

2

High-throughput

0.479

High

576247

PO2F1
POU domain, class 2, transcription factor 1

1

1

Small-scale

0.479

High

897339

CDK7
Cyclin-dependent kinase 7

1

6

High-throughput

0.479

High

970781

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

1051268

KPCZ
Protein kinase C zeta type

1

12

High-throughput

0.479

High

1229827

CYTSA
Cytospin-A

1

20

High-throughput

0.479

High

1280337

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

8

High-throughput

0.479

High

1308461

VRK3
Serine/threonine-protein kinase VRK3

1

13

High-throughput

0.479

High

1328650

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.479

High

1328655

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

1328676

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

14

Small-scale

0.479

High

1328687

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1328689

UBQL2
Ubiquilin-2

1

2

High-throughput

0.479

High

1328697

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

1328702

RPGF2
Rap guanine nucleotide exchange factor 2

1

5

High-throughput

0.479

High

47374

A0A6Q8PF08
Peripheral myelin protein 22

1

1

High-throughput

0.470

High

109463

G5E9A7
DM1 locus, WD repeat containing

1

9

High-throughput

0.470

High

280723

PR40A
Pre-mRNA-processing factor 40 homolog A

1

12

High-throughput

0.470

High

324014

CSTN1
Calsyntenin-1

1

2

High-throughput

0.470

High

562229

LAMP2
Lysosome-associated membrane glycoprotein 2

1

5

High-throughput

0.470

High

728796

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

3

High-throughput

0.470

High

1023575

CYC
Cytochrome c

1

1

High-throughput

0.470

High

1081547

Q0VDC6
peptidylprolyl isomerase

1

3

High-throughput

0.470

High

1096101

TADBP
TAR DNA-binding protein 43

1

9

High-throughput

0.470

High

1279635

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

3

High-throughput

0.470

High

867804

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

High-throughput

0.458

High

1328664

Q9BVR6
Gamma-tubulin complex component

1

1

High-throughput

0.457

High

1328647

LMO7
LIM domain only protein 7

1

12

High-throughput

0.445

High

1328674

NT5D2
5'-nucleotidase domain-containing protein 2

1

1

High-throughput

0.445

High

1328703

ASB1
Ankyrin repeat and SOCS box protein 1

1

16

High-throughput

0.445

High

1328688

GCP4
Gamma-tubulin complex component 4

1

1

High-throughput

0.439

High

275984

DUS11
RNA/RNP complex-1-interacting phosphatase

1

1

High-throughput

0.437

High

957439

UBC12
NEDD8-conjugating enzyme Ubc12

1

9

High-throughput

0.437

High

1328678

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.437

High

1119481

RUNX2
Runt-related transcription factor 2

1

0

High-throughput

0.426

High

1157659

CRY1
Cryptochrome-1

1

0

High-throughput

0.426

High

1186177

INAVA
Innate immunity activator protein

1

0

High-throughput

0.426

High

1271329

MON1B
Vacuolar fusion protein MON1 homolog B

1

0

High-throughput

0.426

High

1328651

NEIL2
Endonuclease 8-like 2

1

0

High-throughput

0.426

High

71061

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

20

High-throughput

0.407

High

662072

DGKA
Diacylglycerol kinase alpha

1

4

High-throughput

0.407

High

841830

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

3

High-throughput

0.407

High

1186214

CEA21
Cell adhesion molecule CEACAM21

1

5

High-throughput

0.407

High

1249923

CCBE1
Collagen and calcium-binding EGF domain-containing protein 1

1

5

High-throughput

0.407

High

1328654

TRM2B
tRNA

1

1

High-throughput

0.407

High

1328690

EGFL7
Epidermal growth factor-like protein 7

1

5

High-throughput

0.407

High

1328691

TRPS1
Zinc finger transcription factor Trps1

1

1

High-throughput

0.407

High

1179179

CTC1
CST complex subunit CTC1

4

0

High-throughput

0.360

High

1323517

ZN687
Zinc finger protein 687

3

0

High-throughput

0.347

High

1328671

THAP9
DNA transposase THAP9

3

0

High-throughput

0.347

High

220389

LAT
Linker for activation of T-cells family member 1

2

0

High-throughput

0.316

High

1328672

STN1
CST complex subunit STN1

2

0

High-throughput

0.313

High

1328662

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.299

High

912203

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.279

Low

1229220

ZNF57
Zinc finger protein 57

1

0

High-throughput

0.279

Low

1328675

FBRS
Probable fibrosin-1

1

0

High-throughput

0.279

Low

1328679

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

1328680

ZN358
Zinc finger protein 358

1

0

High-throughput

0.279

Low

1328686

CGBP1
CGG triplet repeat-binding protein 1

1

0

High-throughput

0.279

Low

1328692

NARF
Nuclear prelamin A recognition factor

1

0

High-throughput

0.279

Low

1212420

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.268

Low

1328652

Q96BH6
LAMC1 protein

1

0

High-throughput

0.268

Low

1191378

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low

1180681

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.249

Low

1328694

DBR1
Lariat debranching enzyme

1

0

High-throughput

0.249

Low

839591

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.232

Low

1017794

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.232

Low

1121013

VGLL4
Transcription cofactor vestigial-like protein 4

1

0

High-throughput

0.232

Low

1218138

DC121
DDB1- and CUL4-associated factor 12-like protein 1

1

0

High-throughput

0.232

Low

1328665

TR61B
tRNA

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025