Protein: KCTD5
BTB/POZ domain-containing protein KCTD5

Gene: KCTD5
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q9NXV2

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1114460

CUL3
Cullin-3

11

20

Small-scale

0.976

High

1328682

KCD17
BTB/POZ domain-containing protein KCTD17

5

15

Small-scale

0.919

High

1452131

KCTD5
BTB/POZ domain-containing protein KCTD5

4

17

Small-scale

0.898

High

1452134

KCND2
A-type voltage-gated potassium channel KCND2

2

17

High-throughput

0.811

High

1113002

CUL2
Cullin-2

1

20

High-throughput

0.665

High

1150493

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

3

20

High-throughput

0.662

High

1327846

ARRD1
Arrestin domain-containing protein 1

3

5

High-throughput

0.650

High

1130028

KCTD2
BTB/POZ domain-containing protein KCTD2

1

15

Small-scale

0.618

High

447511

NPM
Nucleophosmin

2

3

High-throughput

0.611

High

1212245

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

20

High-throughput

0.611

High

1390392

CNRP1
CB1 cannabinoid receptor-interacting protein 1

2

1

High-throughput

0.611

High

983598

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

2

14

Small-scale

0.584

High

541717

FGFR1
Fibroblast growth factor receptor 1

2

7

High-throughput

0.571

High

1144553

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

10

High-throughput

0.571

High

948085

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

2

12

Small-scale

0.558

High

1067771

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.541

High

1438785

NEK6
Serine/threonine-protein kinase Nek6

1

6

High-throughput

0.541

High

1452137

NXF1
Nuclear RNA export factor 1

1

4

High-throughput

0.541

High

162869

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

20

High-throughput

0.536

High

228927

CF410
Cilia- and flagella-associated protein 410

1

20

High-throughput

0.536

High

732418

PRDX2
Peroxiredoxin-2

1

5

High-throughput

0.536

High

872811

SOX2
Transcription factor SOX-2

1

5

High-throughput

0.536

High

975988

RL7A
Large ribosomal subunit protein eL8

1

1

High-throughput

0.536

High

1037674

RL18A
Large ribosomal subunit protein eL20

1

1

High-throughput

0.536

High

1061182

SRSF1
Serine/arginine-rich splicing factor 1

1

7

High-throughput

0.536

High

1410756

MBB1A
Myb-binding protein 1A

1

1

High-throughput

0.536

High

1416083

REPI1
DNA-binding protein REPIN1

1

2

High-throughput

0.536

High

1452136

POLK
DNA polymerase kappa

1

2

High-throughput

0.536

High

756376

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.529

High

1400280

F193B
Protein FAM193B

1

0

Small-scale

0.529

High

1452142

ZN711
Zinc finger protein 711

1

0

Small-scale

0.529

High

225707

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.518

High

1151672

TRIP6
Thyroid receptor-interacting protein 6

1

7

High-throughput

0.515

High

1361780

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.513

High

438915

CD1A
T-cell surface glycoprotein CD1a

1

2

High-throughput

0.494

High

1122453

GIT2
ARF GTPase-activating protein GIT2

1

16

High-throughput

0.494

High

1413889

ZN692
Zinc finger protein 692

1

1

High-throughput

0.489

High

173459

XPO1
Exportin-1

1

14

High-throughput

0.479

High

243126

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

257510

PAGE4
P antigen family member 4

1

2

High-throughput

0.479

High

294429

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

316079

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

320097

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

350153

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

397077

ESR1
Estrogen receptor

1

9

High-throughput

0.479

High

482548

F16P1
Fructose-1,6-bisphosphatase 1

1

2

High-throughput

0.479

High

535598

BIP
Endoplasmic reticulum chaperone BiP

1

19

High-throughput

0.479

High

604237

CXA1
Gap junction alpha-1 protein

1

6

Small-scale

0.479

High

675183

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

High-throughput

0.479

High

762057

GRK5
G protein-coupled receptor kinase 5

1

7

High-throughput

0.479

High

897409

CDK7
Cyclin-dependent kinase 7

1

5

High-throughput

0.479

High

912613

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

Small-scale

0.479

High

957527

UBC12
NEDD8-conjugating enzyme Ubc12

1

7

High-throughput

0.479

High

971189

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

984310

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

14

Small-scale

0.479

High

1008568

ELF3
ETS-related transcription factor Elf-3

1

1

High-throughput

0.479

High

1051327

KPCZ
Protein kinase C zeta type

1

9

High-throughput

0.479

High

1092257

NFX1
Transcriptional repressor NF-X1

1

6

High-throughput

0.479

High

1104515

ILK
Scaffold protein ILK

1

3

High-throughput

0.479

High

1197576

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

2

High-throughput

0.479

High

1255824

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

1358119

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.479

High

1380206

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.479

High

1393765

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

1396833

SNX27
Sorting nexin-27

1

20

High-throughput

0.479

High

1402326

RANB9
Ran-binding protein 9

1

5

High-throughput

0.479

High

1428562

DDX24
ATP-dependent RNA helicase DDX24

1

6

High-throughput

0.479

High

1431661

GAN
Gigaxonin

1

5

High-throughput

0.479

High

1432528

P63
Tumor protein 63

1

3

Small-scale

0.479

High

1435367

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1437748

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

14

Small-scale

0.479

High

1438987

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

7

High-throughput

0.479

High

1446971

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1452138

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1452139

UBQL2
Ubiquilin-2

1

2

High-throughput

0.479

High

1452141

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

1452143

RPGF2
Rap guanine nucleotide exchange factor 2

1

5

High-throughput

0.479

High

1452144

MAFB
Transcription factor MafB

1

1

High-throughput

0.479

High

1451189

TM45A
Transmembrane protein 45A

1

2

High-throughput

0.470

High

1083476

MN1
Transcriptional activator MN1

1

0

Small-scale

0.458

High

890688

RGS3
Regulator of G-protein signaling 3

1

10

High-throughput

0.445

High

243477

GBG7

1

12

Small-scale

0.437

High

378192

TNFA
Tumor necrosis factor

1

1

High-throughput

0.437

High

635286

EFNA1
Ephrin-A1

1

2

High-throughput

0.437

High

914218

EFNA3
Ephrin-A3

1

2

High-throughput

0.437

High

914358

EFNA4
Ephrin-A4

1

2

High-throughput

0.437

High

1215863

RC3H1
Roquin-1

1

1

High-throughput

0.437

High

1436703

GORS2
Golgi reassembly-stacking protein 2

1

8

Small-scale

0.437

High

1438047

RC3H2
Roquin-2

1

8

High-throughput

0.437

High

1452133

PD1L1
Programmed cell death 1 ligand 1

1

10

Small-scale

0.437

High

1452135

GBG12

1

12

Small-scale

0.437

High

71069

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

20

High-throughput

0.407

High

548132

PSPC
Surfactant protein C

1

2

High-throughput

0.407

High

844886

EAA1
Excitatory amino acid transporter 1

1

5

High-throughput

0.407

High

1452140

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

12

High-throughput

0.407

High

1386038

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.279

Low

1452132

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

653615

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025