Protein: CDK5
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)

Gene: CDK5
Organism: Mus musculus
Interactions: 27
UniProt ID: P49615

Gene Ontology (top 5):
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001764 - neuron migration
GO:0001963 - synaptic transmission, dopaminergic
GO:0002039 - p53 binding
GO:0004672 - protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

884984

CD5R1
Cyclin-dependent kinase 5 activator 1

3

7

Small-scale

0.834

High

884988

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

1

High-throughput

0.691

High

543018

CDK1
Cyclin-dependent kinase 1

1

17

Small-scale

0.647

High

581974

NTRK2
BDNF/NT-3 growth factors receptor

1

17

Small-scale

0.646

High

813505

FYN
Tyrosine-protein kinase Fyn

1

14

Small-scale

0.618

High

884989

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

10

Small-scale

0.618

High

884990

DLG4
Disks large homolog 4

2

2

High-throughput

0.611

High

884994

DLGP1
Disks large-associated protein 1

2

1

High-throughput

0.611

High

884985

DAB1
Disabled homolog 1

2

4

Small-scale

0.602

High

530728

TAU
Microtubule-associated protein tau

2

6

Small-scale

0.595

High

236746

PER2
Period circadian protein homolog 2

1

2

Small-scale

0.578

High

884996

CHIP
E3 ubiquitin-protein ligase CHIP

1

10

Small-scale

0.578

High

548938

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

8

Small-scale

0.575

High

591107

MET
Hepatocyte growth factor receptor

1

11

High-throughput

0.575

High

884995

TSC1
Hamartin

1

17

High-throughput

0.536

High

534010

H10
Histone H1.0

1

8

Small-scale

0.501

High

847008

H11
Histone H1.1

1

20

Small-scale

0.501

High

619279

NFH
Neurofilament heavy polypeptide

1

6

Small-scale

0.479

High

840611

PURA
Transcriptional activator protein Pur-alpha

1

1

Small-scale

0.479

High

884991

WDTC1
WD and tetratricopeptide repeats protein 1

1

8

High-throughput

0.479

High

884992

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

6

High-throughput

0.479

High

884993

DPPA3
Developmental pluripotency-associated protein 3

1

1

Small-scale

0.479

High

884997

SEPT5
Septin-5

1

4

Small-scale

0.479

High

108528

G3X9H5
Huntingtin

1

0

High-throughput

0.458

High

884987

ESYT1
Extended synaptotagmin-1

1

1

Small-scale

0.445

High

884986

TRI72
Tripartite motif-containing protein 72

1

7

Small-scale

0.437

High

884983

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.426

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025