HitPredict

Interactor 1: EI2BE (Q13144)
Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon)
Gene: EIF2B5

Interactor 2: GMPPB (Q9Y5P6)
Mannose-1-phosphate guanyltransferase beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta)
Gene: GMPPB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 721 Hs			1 360
+	Hs
		1025673 EI2BE_HUMAN (14-711): 0: 634: 100.00		GMPPA_HUMAN (1-359): 1.38e-117: 348: 31.74
+	Hs
		1025697 EI2BE_HUMAN (14-711): 0: 634: 100.00		EI2BG_HUMAN (2-349): 9.66e-66: 216: 14.35
+	Sc
		691727 EI2BE_YEAST (15-714): 0: 544: 27.55		EI2BE_YEAST (1-352): 3.13e-87: 279: 16.35
+	Sp
		880375 EI2BE_SCHPO (29-713): 0: 569: 31.63		EI2BG_SCHPO (2-357): 1.44e-65: 216: 16.14
+	Sp
		251586 MPG1_SCHPO (43-455): 1.35e-96: 304: 12.68		MPG1_SCHPO (1-360): 2.96e-141: 406: 59.95
+	Dm
		54798 Q9W541_DROME (39-714): 4.25e-159: 477: 30.51		A1ZA22_DROME (2-358): 3.48e-63: 209: 13.61
+	Hs
		1294505 GMPPB_HUMAN (43-457): 1.51e-100: 315: 14.09		GMPPA_HUMAN (1-359): 1.38e-117: 348: 31.74
+	Hs
		1294494 GMPPA_HUMAN (43-452): 4.16e-94: 300: 17.43		GMPPA_HUMAN (1-359): 1.38e-117: 348: 31.74
+	At
		186857 GMPP1_ARATH (43-457): 1.42e-98: 309: 16.71		Q9C9P3_ARATH (3-359): 3.12e-113: 337: 30.37
+	At
		186856 GMPP1_ARATH (43-457): 1.42e-98: 309: 16.71		Q8W4J5_ARATH (3-359): 1e-112: 335: 31.08
+	At
		96218 GMPP1_ARATH (43-457): 1.42e-98: 309: 16.71		F4IFA4_ARATH (3-359): 8.82e-113: 335: 31.08
+	Dm
		1178205 GMPPB_DROME (44-457): 9.15e-98: 308: 15.04		Q8SXU3_DROME (1-359): 1.82e-105: 318: 27.92
+	Sp
		223845 MPG1_SCHPO (43-455): 1.35e-96: 304: 12.68		YBB2_SCHPO (3-359): 1.18e-106: 320: 28.05
+	At
		1259072 Q9C9P3_ARATH (36-455): 8.6e-89: 286: 13.36		Q8W4J5_ARATH (3-359): 1e-112: 335: 31.08
+	At
		96219 Q9C9P3_ARATH (36-455): 8.6e-89: 286: 13.36		F4IFA4_ARATH (3-359): 8.82e-113: 335: 31.08
+	Ss
		854225 GLGC_SYNY3 (42-449): 1.88e-96: 307: 14.13		GLGC_SYNY3 (3-360): 3.21e-94: 289: 18.46
+	At
		877183 GLGS_ARATH (4-449): 1.66e-97: 312: 14.52		GLGL4_ARATH (3-360): 2.93e-85: 269: 14.02