HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: SETB1 (Q15047)
Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)
Gene: SETDB1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 1291
+	Hs
		800384 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		SETB1_HUMAN (1-1291): 0: 1373: 100.00
+	Hs
		1027268 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27
+	Mm
		1125433 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		EHMT1_MOUSE (995-1287): 2.13e-66: 248: 21.84
+	Hs
		203674 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Mm
		1322180 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		EHMT2_MOUSE (999-1287): 7.04e-65: 243: 19.11
+	Hs
		1027194 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11
+	Mm
		222468 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		SUV91_MOUSE (658-970): 1.78e-68: 238: 22.39
+	Mm
		222460 CBX3_MOUSE (1-183): 4.67e-71: 214: 99.45		SUV91_MOUSE (658-970): 1.78e-68: 238: 22.39
+	Mm
		613035 CBX3_MOUSE (1-183): 4.67e-71: 214: 99.45		SUV92_MOUSE (658-941): 3.14e-67: 237: 23.05
+	Hs
		1027262 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		SUV92_HUMAN (973-1290): 2.24e-67: 235: 20.98
+	Hs
		1027242 CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00		SETD2_HUMAN (911-1290): 1.29e-53: 209: 16.00
+	Mm
		936655 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		EZH1_MOUSE (1026-1272): 2.84e-55: 208: 13.90
+	Hs
		203638 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Hs
		203823 V9HWG0_HUMAN (11-182): 1.62e-55: 175: 59.89		SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56
+	Mm
		1143050 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		EHMT2_MOUSE (999-1287): 7.04e-65: 243: 19.11
+	Mm
		222467 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		SUV91_MOUSE (658-970): 1.78e-68: 238: 22.39
+	Hs
		1331984 V9HWG0_HUMAN (11-182): 1.62e-55: 175: 59.89		SUV92_HUMAN (973-1290): 2.24e-67: 235: 20.98
+	Mm
		1142295 Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00		EZH2_MOUSE (1026-1272): 1.15e-48: 188: 13.13
+	Mm
		1142272 CBX5_MOUSE (11-182): 1.21e-55: 175: 59.89		EZH2_MOUSE (1026-1272): 1.15e-48: 188: 13.13
+	Hs
		800391 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13