Protein: AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Apoptotic regulator in the membrane of the endoplasmic reticulum)

Gene: AR6P1, ARL6IP1
Organism: Homo sapiens
Interactions: 208
UniProt ID: Q15041

Gene Ontology (top 5):
GO:0002038 - positive regulation of L-glutamate import across plasma membrane
GO:0005783 - endoplasmic reticulum
GO:0005784 - Sec61 translocon complex
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1139279

RTN4
Reticulon-4

5

2

High-throughput

0.721

High

1139215

RETR3
Reticulophagy regulator 3

4

2

High-throughput

0.705

High

1139308

CERT
Ceramide transfer protein

5

0

High-throughput

0.691

High

1139281

DBLOH
Diablo IAP-binding mitochondrial protein

4

0

High-throughput

0.675

High

1139310

SNX10
Sorting nexin-10

3

8

High-throughput

0.675

High

1139257

INP5K
Inositol polyphosphate 5-phosphatase K

4

0

High-throughput

0.671

High

882681

EFTU
Elongation factor Tu, mitochondrial

3

1

High-throughput

0.670

High

1050845

DCE2
Glutamate decarboxylase 2

3

0

High-throughput

0.646

High

1139291

SPG21
Maspardin

3

0

High-throughput

0.646

High

1139301

NDRG4
Protein NDRG4

3

0

High-throughput

0.646

High

1111913

SNX1
Sorting nexin-1

2

5

High-throughput

0.640

High

1139193

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

3

0

High-throughput

0.639

High

1139294

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

4

1

High-throughput

0.633

High

668990

FPR2
N-formyl peptide receptor 2

2

1

High-throughput

0.628

High

1139283

SNX15
Sorting nexin-15

2

6

High-throughput

0.628

High

1139275

GORS2
Golgi reassembly-stacking protein 2

2

0

High-throughput

0.618

High

1139251

ZFY21
Zinc finger FYVE domain-containing protein 21

3

1

High-throughput

0.616

High

1139302

SNX12
Sorting nexin-12

3

7

High-throughput

0.616

High

1139309

SNX11
Sorting nexin-11

3

7

High-throughput

0.616

High

900337

FXR2
RNA-binding protein FXR2

2

0

High-throughput

0.613

High

328917

RTN3
Reticulon-3

2

2

High-throughput

0.611

High

1027006

REEP5
Receptor expression-enhancing protein 5

2

3

High-throughput

0.611

High

1139255

ESYT1
Extended synaptotagmin-1

2

1

High-throughput

0.611

High

1139273

RETR1
Reticulophagy regulator 1

2

2

Small-scale

0.611

High

255425

SNX2
Sorting nexin-2

2

5

High-throughput

0.606

High

1139214

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

2

High-throughput

0.606

High

1139241

STAR4
StAR-related lipid transfer protein 4

2

1

High-throughput

0.606

High

1139245

REEP6
Receptor expression-enhancing protein 6

2

3

High-throughput

0.606

High

1139250

RNF5
E3 ubiquitin-protein ligase RNF5

2

1

High-throughput

0.606

High

1139311

SNX8
Sorting nexin-8

2

5

High-throughput

0.606

High

1139274

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.602

High

903915

BAP31
B-cell receptor-associated protein 31

2

0

High-throughput

0.585

High

140274

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

166915

MGST3
Glutathione S-transferase 3, mitochondrial

2

0

High-throughput

0.580

High

353690

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

932687

EMP1
Epithelial membrane protein 1

2

0

High-throughput

0.580

High

958564

TM258
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258

2

0

High-throughput

0.580

High

1139202

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

2

0

High-throughput

0.580

High

1139205

MF14B
Hippocampus abundant transcript-like protein 1

2

0

High-throughput

0.580

High

1139209

MFSD5
Molybdate-anion transporter

2

0

High-throughput

0.580

High

1139218

SHSA5
Protein shisa-5

2

0

High-throughput

0.580

High

1139225

CS018
Uncharacterized protein C19orf18

2

0

High-throughput

0.580

High

1139244

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1139256

YIPF4
Protein YIPF4

2

0

High-throughput

0.580

High

1139282

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

1139288

TM248
Transmembrane protein 248

2

0

High-throughput

0.580

High

1139292

EHD3
EH domain-containing protein 3

2

0

High-throughput

0.580

High

249615

SNX3
Sorting nexin-3

1

7

High-throughput

0.573

High

329836

SNX4
Sorting nexin-4

1

3

High-throughput

0.573

High

1139270

GOLP3
Golgi phosphoprotein 3

1

2

High-throughput

0.573

High

1139307

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

1

High-throughput

0.573

High

1139230

TM10A
tRNA methyltransferase 10 homolog A

2

0

High-throughput

0.559

High

46760

A0A384ME17
Elongation factor Tu

2

1

High-throughput

0.558

High

1139231

GP152
Probable G-protein coupled receptor 152

2

2

High-throughput

0.553

High

1139247

WDFY2
WD repeat and FYVE domain-containing protein 2

2

2

High-throughput

0.553

High

1024044

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.549

High

1139242

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.549

High

1139277

SENP2
Sentrin-specific protease 2

1

0

High-throughput

0.549

High

48627

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.536

High

297203

PRAF3
PRA1 family protein 3

1

1

High-throughput

0.536

High

773508

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.536

High

921900

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

1139224

RETR2
Reticulophagy regulator 2

1

2

High-throughput

0.536

High

1139228

ATLA2
Atlastin-2

1

3

High-throughput

0.536

High

1139272

REEP4
Receptor expression-enhancing protein 4

1

3

High-throughput

0.536

High

1139293

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

1139297

PRAF1
Prenylated Rab acceptor protein 1

1

1

High-throughput

0.536

High

789897

FDFT
Squalene synthase

1

0

High-throughput

0.518

High

1139235

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.518

High

1139221

Q8N5Z3
Sorting nexin 10

1

8

High-throughput

0.515

High

167155

T4S5
Transmembrane 4 L6 family member 5

1

0

High-throughput

0.513

High

337947

CNEP1
CTD nuclear envelope phosphatase 1

1

0

High-throughput

0.513

High

529820

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

857108

NSF
Vesicle-fusing ATPase

1

0

High-throughput

0.513

High

956295

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.513

High

1092370

TSN31
Tetraspanin-31

1

0

High-throughput

0.513

High

1139233

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.513

High

1139240

FAF2
FAS-associated factor 2

1

0

High-throughput

0.513

High

1139243

BSCL2
Seipin

1

0

High-throughput

0.513

High

1139269

GLP3L
Golgi phosphoprotein 3-like

1

2

High-throughput

0.508

High

169556

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

Small-scale

0.501

High

352707

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.486

High

777610

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.486

High

993576

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

1139264

ARL6
ADP-ribosylation factor-like protein 6

1

1

Small-scale

0.481

High

1139200

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.479

High

1139208

ATLA3
Atlastin-3

1

3

High-throughput

0.479

High

95725

E5KS60
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

1

High-throughput

0.470

High

1139204

Q5JS98
PBX homeobox 3

1

1

High-throughput

0.470

High

1139213

Q7KZS0
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.470

High

385758

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.460

High

1139260

B2L13
Bcl-2-like protein 13

1

0

Small-scale

0.460

High

130105

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.458

High

378491

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

413861

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

852758

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

0

High-throughput

0.458

High

942620

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

990245

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.458

High

1139206

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.458

High

1139207

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.458

High

1139219

GPD1L
Glycerol-3-phosphate dehydrogenase 1-like protein

1

0

High-throughput

0.458

High

1139296

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

High-throughput

0.458

High

1139299

KS6A6
Ribosomal protein S6 kinase alpha-6

1

0

High-throughput

0.458

High

1139300

AMFR
E3 ubiquitin-protein ligase AMFR

1

0

Small-scale

0.458

High

104338

F5H6I7
Atlastin GTPase 3

1

3

High-throughput

0.445

High

275515

RTN2
Reticulon-2

1

2

High-throughput

0.445

High

296499

STAM2
Signal transducing adapter molecule 2

1

1

High-throughput

0.445

High

333008

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.445

High

697883

CALR
Calreticulin

1

1

High-throughput

0.445

High

698674

CALX
Calnexin

1

1

High-throughput

0.445

High

886058

CXCR3
C-X-C chemokine receptor type 3

1

1

High-throughput

0.445

High

888870

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.445

High

1139197

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.445

High

1139203

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

3

High-throughput

0.445

High

1139217

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.445

High

1139223

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.445

High

1139234

ATLA1
Atlastin-1

1

3

High-throughput

0.445

High

1139246

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.445

High

1139268

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.445

High

1139295

COPG2
Coatomer subunit gamma-2

1

1

High-throughput

0.445

High

1139304

DHRS7
Dehydrogenase/reductase SDR family member 7

1

2

High-throughput

0.445

High

1139305

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.445

High

1139313

COPG1
Coatomer subunit gamma-1

1

1

High-throughput

0.445

High

823940

PBX3
Pre-B-cell leukemia transcription factor 3

1

1

High-throughput

0.439

High

1139271

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

50557

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.426

High

60342

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

158208

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.426

High

211789

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

213602

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.426

High

215564

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.426

High

283252

ERLN1
Erlin-1

1

0

High-throughput

0.426

High

359989

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.426

High

462423

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.426

High

535079

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

566982

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.426

High

873226

COPD
Coatomer subunit delta

1

0

High-throughput

0.426

High

876861

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.426

High

883096

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.426

High

903698

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.426

High

921670

COPB
Coatomer subunit beta

1

0

High-throughput

0.426

High

964004

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.426

High

987035

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

1009834

NUCB2
Nucleobindin-2

1

0

High-throughput

0.426

High

1096962

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.426

High

1131261

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.426

High

1136202

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.426

High

1139194

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

1139195

S39AE
Metal cation symporter ZIP14

1

0

High-throughput

0.426

High

1139196

RCN1
Reticulocalbin-1

1

0

High-throughput

0.426

High

1139198

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

1139199

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.426

High

1139211

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

1139212

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.426

High

1139220

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

1139222

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.426

High

1139226

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.426

High

1139227

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.426

High

1139229

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.426

High

1139236

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.426

High

1139239

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

1139248

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1139254

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.426

High

1139258

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.426

High

1139261

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.426

High

1139263

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.426

High

1139265

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.426

High

1139267

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

1139278

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.426

High

1139284

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.426

High

1139286

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.426

High

1139290

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

1139312

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.426

High

1139238

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

5

0

High-throughput

0.375

High

760921

GLYM
Serine hydroxymethyltransferase, mitochondrial

2

0

High-throughput

0.337

High

1032584

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

0

High-throughput

0.328

High

1139276

MYG1
MYG1 exonuclease

2

0

High-throughput

0.319

High

849000

PTN9
Tyrosine-protein phosphatase non-receptor type 9

2

0

High-throughput

0.316

High

1108898

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

1139201

SOAT
Sodium-dependent organic anion transporter

2

0

High-throughput

0.316

High

1139210

TMED8
Protein TMED8

2

0

High-throughput

0.316

High

1139216

MCEM1
Mast cell-expressed membrane protein 1

2

0

High-throughput

0.316

High

1139232

GP151
G-protein coupled receptor 151

2

0

High-throughput

0.316

High

1139237

MID49
Mitochondrial dynamics protein MID49

2

0

High-throughput

0.316

High

1139259

SYTM
Threonine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

1139280

S35C2
Solute carrier family 35 member C2

2

0

High-throughput

0.316

High

1139285

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

1120106

RB33A
Ras-related protein Rab-33A

1

0

High-throughput

0.299

High

1139266

SNAB
Beta-soluble NSF attachment protein

1

0

High-throughput

0.299

High

1139306

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

0

High-throughput

0.299

High

936049

PAR2
Proteinase-activated receptor 2

1

0

High-throughput

0.282

High

608273

EGLN
Endoglin

1

0

High-throughput

0.279

Low

618382

TSN8
Tetraspanin-8

1

0

High-throughput

0.279

Low

900823

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.279

Low

1031375

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.279

Low

322142

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.269

Low

1139303

TR150
Thyroid hormone receptor-associated protein 3

1

0

High-throughput

0.269

Low

1139262

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

1139298

ZN391
Zinc finger protein 391

1

0

High-throughput

0.251

Low

1004585

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1139249

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.249

Low

318981

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.232

Low

1015023

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.232

Low

1139252

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

0

High-throughput

0.232

Low

1139253

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.232

Low

1139287

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low

1139289

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025