HitPredict

Interactor 1: DNJC3 (Q13217)
DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)
Gene: DNAJC3

Interactor 2: TXND5 (Q8NBS9)
Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46)
Gene: TXNDC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33957083
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DnaJ~Thioredoxin
Common GO terms	GO:0005576 - extracellular region GO:0005783 - endoplasmic reticulum GO:0005788 - endoplasmic reticulum lumen GO:0035578 - azurophil granule lumen GO:0043066 - negative regulation of apoptotic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 504 Hs			1 432
+	Hs
		1240431 DNJB9_HUMAN (391-503): 1.35e-35: 134: 35.77		TXND5_HUMAN (1-432): 2.46e-124: 369: 100.00
+	Hs
		1028048 DNJC3_HUMAN (1-504): 1.15e-88: 282: 100.00		PDIA6_HUMAN (15-338): 8.51e-39: 147: 18.00
+	Hs
		531816 DNJC3_HUMAN (1-504): 1.15e-88: 282: 100.00		PDIA4_HUMAN (16-191): 7.57e-36: 141: 24.29
+	Hs
		423218 DNJC3_HUMAN (1-504): 1.15e-88: 282: 100.00		PDIA1_HUMAN (56-432): 1.58e-28: 119: 16.41
+	Hs
		671805 DNJC3_HUMAN (1-504): 1.15e-88: 282: 100.00		PDIA3_HUMAN (22-298): 1.27e-20: 95.8: 16.67
+	Hs
		1028076 DNJC3_HUMAN (1-504): 1.15e-88: 282: 100.00		DJC10_HUMAN (92-405): 1.63e-18: 90: 18.13
+	Dm
		1359554 Q9VHA8_DROME (33-504): 1.83e-64: 219: 43.86		PDIA6_DROME (15-237): 1.32e-31: 127: 18.40
+	Hs
		531908 TTC13_HUMAN (34-337): 1.83e-49: 183: 21.36		PDIA4_HUMAN (16-191): 7.57e-36: 141: 24.29
+	Dm
		870464 Q9VHA8_DROME (33-504): 1.83e-64: 219: 43.86		PDI_DROME (320-431): 6.41e-23: 102: 35.71
+	Hs
		1067840 DJB12_HUMAN (381-495): 7.69e-35: 136: 36.98		PDIA6_HUMAN (15-338): 8.51e-39: 147: 18.00
+	Hs
		1067845 DNJB9_HUMAN (391-503): 1.35e-35: 134: 35.77		PDIA6_HUMAN (15-338): 8.51e-39: 147: 18.00
+	Hs
		532000 DJB12_HUMAN (381-495): 7.69e-35: 136: 36.98		PDIA4_HUMAN (16-191): 7.57e-36: 141: 24.29
+	Hs
		532010 DNJB9_HUMAN (391-503): 1.35e-35: 134: 35.77		PDIA4_HUMAN (16-191): 7.57e-36: 141: 24.29
+	Hs
		1220432 TTC13_HUMAN (34-337): 1.83e-49: 183: 21.36		DJC10_HUMAN (92-405): 1.63e-18: 90: 18.13
+	Hs
		531878 TMTC3_HUMAN (9-308): 2.55e-27: 118: 11.59		PDIA4_HUMAN (16-191): 7.57e-36: 141: 24.29
+	Hs
		423372 DJB12_HUMAN (381-495): 7.69e-35: 136: 36.98		PDIA1_HUMAN (56-432): 1.58e-28: 119: 16.41
+	Hs
		423379 DNJB9_HUMAN (391-503): 1.35e-35: 134: 35.77		PDIA1_HUMAN (56-432): 1.58e-28: 119: 16.41
+	Hs
		671939 DJB12_HUMAN (381-495): 7.69e-35: 136: 36.98		PDIA3_HUMAN (22-298): 1.27e-20: 95.8: 16.67
+	Hs
		671947 DNJB9_HUMAN (391-503): 1.35e-35: 134: 35.77		PDIA3_HUMAN (22-298): 1.27e-20: 95.8: 16.67
+	Rn
		956846 DNJB9_RAT (391-504): 2.74e-35: 132: 36.67		DJC10_RAT (92-411): 1.44e-17: 87.3: 15.63