Protein: SPTN4
Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)

Gene: SPTN4, SPTBN4
Organism: Homo sapiens
Interactions: 49
UniProt ID: Q9H254

Gene Ontology (top 5):
GO:0002028 - regulation of sodium ion transport
GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005543 - phospholipid binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

578543

BRAF
Serine/threonine-protein kinase B-raf

2

8

High-throughput

0.737

High

1295210

HOME1
Homer protein homolog 1

3

20

High-throughput

0.667

High

1431497

PCDGK
Protocadherin gamma-C3

2

1

High-throughput

0.628

High

1117474

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

Small-scale

0.621

High

386488

SPTA1
Spectrin alpha chain, erythrocytic 1

1

19

Small-scale

0.618

High

1028869

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

20

High-throughput

0.618

High

1091457

ANK3
Ankyrin-3

1

20

Small-scale

0.618

High

411048

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

11

High-throughput

0.575

High

1164082

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

5

Small-scale

0.573

High

1431493

DISC1
Disrupted in schizophrenia 1 protein

1

9

Small-scale

0.573

High

530366

TAU
Microtubule-associated protein tau

2

17

Small-scale

0.552

High

1121649

MORC3
MORC family CW-type zinc finger protein 3

1

1

High-throughput

0.541

High

943863

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.518

High

292396

RA51D
DNA repair protein RAD51 homolog 4

1

4

High-throughput

0.515

High

577500

ETS1
Protein C-ets-1

1

3

High-throughput

0.515

High

317529

TPPP
Tubulin polymerization-promoting protein

1

0

High-throughput

0.513

High

946089

ANTR2
Anthrax toxin receptor 2

1

0

High-throughput

0.513

High

1392609

TIMD4
T-cell immunoglobulin and mucin domain-containing protein 4

1

0

High-throughput

0.513

High

665284

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

High-throughput

0.508

High

891782

GSK3B
Glycogen synthase kinase-3 beta

1

20

High-throughput

0.508

High

908857

NEK2
Serine/threonine-protein kinase Nek2

1

16

High-throughput

0.508

High

1370794

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

4

Small-scale

0.508

High

1431496

KS6A6
Ribosomal protein S6 kinase alpha-6

1

5

High-throughput

0.508

High

302124

CDKL5
Cyclin-dependent kinase-like 5

1

14

High-throughput

0.494

High

361819

PNPH
Purine nucleoside phosphorylase

1

0

High-throughput

0.493

High

261873

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.486

High

1158534

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.486

High

1259024

CENPU
Centromere protein U

1

0

High-throughput

0.486

High

1273192

ARC
Activity-regulated cytoskeleton-associated protein

1

0

Small-scale

0.480

High

157840

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.479

High

223325

PRC1
Protein regulator of cytokinesis 1

1

20

High-throughput

0.479

High

331318

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

343279

ERR2
Steroid hormone receptor ERR2

1

20

High-throughput

0.479

High

774614

BASI
Basigin

1

13

High-throughput

0.479

High

1140838

KIF14
Kinesin-like protein KIF14

1

14

High-throughput

0.479

High

1333330

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1385862

CHM4C
Charged multivesicular body protein 4c

1

20

High-throughput

0.479

High

1431490

CHM4B
Charged multivesicular body protein 4b

1

20

High-throughput

0.479

High

1431491

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

1431492

ANLN
Anillin

1

13

High-throughput

0.479

High

1431494

NDE1
Nuclear distribution protein nudE homolog 1

1

19

High-throughput

0.479

High

889503

CLK1
Dual specificity protein kinase CLK1

1

12

High-throughput

0.457

High

1431495

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

1

3

Small-scale

0.457

High

69549

A2ML1
Alpha-2-macroglobulin-like protein 1

1

2

High-throughput

0.445

High

765879

BMI1
Polycomb complex protein BMI-1

1

19

High-throughput

0.445

High

1326084

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

75722

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

2

High-throughput

0.437

High

1048094

TLE3
Transducin-like enhancer protein 3

1

8

High-throughput

0.437

High

1219050

RSBN1
Lysine-specific demethylase 9

2

0

High-throughput

0.328

High


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Last updated: 11Aug2025