HitPredict

Interactor 1: CTBP1 (Q13363)
C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)
Gene: CTBP1

Interactor 2: HIC2 (Q96JB3)
Hypermethylated in cancer 2 protein (Hic-2) (HIC1-related gene on chromosome 22 protein) (Hic-3) (Zinc finger and BTB domain-containing protein 30)
Gene: HIC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	26186194, 28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 615
+	Hs
		781359 CTBP1_HUMAN (1-440): 0: 547: 100.00		BCL6_HUMAN (23-614): 5.08e-117: 365: 21.93
+	Hs
		881179 CTBP2_HUMAN (10-439): 0: 538: 80.23		ZNF79_HUMAN (165-586): 5.47e-106: 330: 18.48
+	Hs
		881255 CTBP2_HUMAN (10-439): 0: 538: 80.23		HIC2_HUMAN (505-614): 7.84e-32: 132: 28.28
+	Hs
		1032405 CTBP1_HUMAN (1-440): 0: 547: 100.00		HIC1_HUMAN (531-614): 1.67e-27: 119: 38.10
+	Hs
		881174 CTBP2_HUMAN (10-439): 0: 538: 80.23		HIC1_HUMAN (531-614): 1.67e-27: 119: 38.10
+	Hs
		1343652 GRHPR_HUMAN (12-348): 1.18e-111: 333: 24.78		PRDM9_HUMAN (107-367): 6.73e-23: 105: 9.92