Protein: PFKAM
ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase)

Gene: PFKAM, PFKM
Organism: Homo sapiens
Interactions: 138
UniProt ID: P08237

Gene Ontology (top 5):
GO:0003872 - 6-phosphofructokinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005945 - 6-phosphofructokinase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

467897

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

7

14

Small-scale

0.956

High

467863

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

2

14

Small-scale

0.793

High

467869

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

2

14

Small-scale

0.757

High

467891

SUMO2
Small ubiquitin-related modifier 2

2

4

High-throughput

0.602

High

240530

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

467866

HSP7C
Heat shock cognate 71 kDa protein

2

2

High-throughput

0.584

High

467929

TBA1A
Tubulin alpha-1A chain

2

2

High-throughput

0.571

High

467915

TEAD4
Transcriptional enhancer factor TEF-3

1

1

High-throughput

0.561

High

467865

TAU
Microtubule-associated protein tau

2

10

Small-scale

0.552

High

467936

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

0

High-throughput

0.549

High

467924

SFRP4
Secreted frizzled-related protein 4

1

1

High-throughput

0.541

High

467946

SFRP2
Secreted frizzled-related protein 2

1

1

High-throughput

0.541

High

467950

RHG07
Rho GTPase-activating protein 7

1

3

High-throughput

0.541

High

467965

VPP4
V-type proton ATPase 116 kDa subunit a 4

1

0

Small-scale

0.537

High

467887

KIF11
Kinesin-like protein KIF11

1

1

High-throughput

0.536

High

467905

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

467906

CUL3
Cullin-3

1

1

High-throughput

0.536

High

467907

CKAP5
Cytoskeleton-associated protein 5

1

1

High-throughput

0.536

High

467920

RHG44
Rho GTPase-activating protein 44

1

2

High-throughput

0.536

High

467951

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

467956

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

2

High-throughput

0.536

High

467977

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

1

High-throughput

0.536

High

467975

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

0

High-throughput

0.518

High

467884

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

467970

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

467873

MK03
Mitogen-activated protein kinase 3

1

11

High-throughput

0.508

High

439620

INSR
Insulin receptor

1

14

High-throughput

0.500

High

467918

NTRK3
NT-3 growth factor receptor

1

14

High-throughput

0.500

High

467913

PGFRL
Platelet-derived growth factor receptor-like protein

1

5

High-throughput

0.494

High

169398

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.480

High

467867

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.480

High

467908

FHL2
Four and a half LIM domains protein 2

1

0

Small-scale

0.480

High

129961

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.479

High

156859

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

222646

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

334493

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

1

Small-scale

0.479

High

362624

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

370964

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

400146

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

405697

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.479

High

411211

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.479

High

439908

LCK
Tyrosine-protein kinase Lck

1

3

High-throughput

0.479

High

467864

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.479

High

467870

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

467872

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

467874

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

467875

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

467876

UFO
Tyrosine-protein kinase receptor UFO

1

12

High-throughput

0.479

High

467879

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

10

High-throughput

0.479

High

467880

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

467881

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

467883

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

467886

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.479

High

467888

CAV3
Caveolin-3

1

1

Small-scale

0.479

High

467890

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.479

High

467893

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

467895

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

467896

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

467898

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

467899

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

Small-scale

0.479

High

467900

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.479

High

467901

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

2

High-throughput

0.479

High

467903

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

467904

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

467911

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.479

High

467912

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

467917

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

467919

DUS6
Dual specificity protein phosphatase 6

1

2

High-throughput

0.479

High

467923

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

467926

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

467930

RHOU
Rho-related GTP-binding protein RhoU

1

9

High-throughput

0.479

High

467931

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

467932

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

467943

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

467944

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

467945

AURKB
Aurora kinase B

1

7

High-throughput

0.479

High

467947

RHOV
Rho-related GTP-binding protein RhoV

1

9

High-throughput

0.479

High

467948

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

467949

LMTK3
Serine/threonine-protein kinase LMTK3

1

19

High-throughput

0.479

High

467952

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

467953

LZTS2
Leucine zipper putative tumor suppressor 2

1

3

High-throughput

0.479

High

467954

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

467958

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.479

High

467959

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.479

High

467960

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.479

High

467966

RHOF
Rho-related GTP-binding protein RhoF

1

8

High-throughput

0.479

High

467968

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

467969

TMPS4
Transmembrane protease serine 4

1

6

High-throughput

0.479

High

467972

HDAC6
Protein deacetylase HDAC6

1

5

High-throughput

0.479

High

467973

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

467974

ANC2
Anaphase-promoting complex subunit 2

1

2

High-throughput

0.479

High

467976

AGO2
Protein argonaute-2

1

1

Small-scale

0.479

High

124202

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

209442

SERA
D-3-phosphoglycerate dehydrogenase

1

0

Small-scale

0.458

High

377364

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

402493

ALDOA
Fructose-bisphosphate aldolase A

1

0

Small-scale

0.458

High

413039

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

467877

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

467882

PERI
Peripherin

1

0

High-throughput

0.458

High

467894

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

467902

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

High-throughput

0.458

High

467909

FLOT2
Flotillin-2

1

0

High-throughput

0.458

High

467914

NONO
Non-POU domain-containing octamer-binding protein

1

0

Small-scale

0.458

High

467934

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

467935

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

467940

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

467942

JOS2
Josephin-2

1

0

Small-scale

0.458

High

467963

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

467967

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.458

High

467971

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

467868

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

467889

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

467892

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.445

High

467921

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

467938

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

467957

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

105153

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

318584

RHBT1
Rho-related BTB domain-containing protein 1

1

9

High-throughput

0.437

High

467878

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

467916

RHOH
Rho-related GTP-binding protein RhoH

1

8

High-throughput

0.437

High

467928

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

467933

SESD1
SEC14 domain and spectrin repeat-containing protein 1

1

1

High-throughput

0.437

High

467937

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.437

High

467941

KDF1
Keratinocyte differentiation factor 1

1

2

High-throughput

0.437

High

467955

RHBT2
Rho-related BTB domain-containing protein 2

1

9

High-throughput

0.437

High

467961

RHOJ
Rho-related GTP-binding protein RhoJ

1

7

High-throughput

0.437

High

467962

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

467885

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

328458

NDUB2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

1

0

High-throughput

0.282

High

467927

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

0

High-throughput

0.279

Low

467964

UBTD1
Ubiquitin domain-containing protein 1

1

0

Small-scale

0.251

Low

467910

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

467922

OTUD1
OTU domain-containing protein 1

1

0

High-throughput

0.249

Low

467925

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

467939

NIN
Ninein

1

0

High-throughput

0.249

Low

254750

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

467871

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025