HitPredict

Interactor 1: GCYB1 (Q02153)
Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit)
Gene: GUCY1B1

Interactor 2: ANKY2 (Q8IV38)
Ankyrin repeat and MYND domain-containing protein 2
Gene: ANKMY2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Guanylate_cyc
Common GO terms	-
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 619 Hs			1 441
+	Hs
		1034926 GCYA1_HUMAN (50-619): 0: 561: 34.13		ANKY2_HUMAN (1-441): 2.17e-107: 326: 100.00
+	Hs
		1064185 ADCY2_HUMAN (198-616): 3.6e-89: 300: 19.78		ANKY2_HUMAN (1-441): 2.17e-107: 326: 100.00
+	Hs
		213327 ADCY6_HUMAN (294-614): 3.6e-79: 273: 23.24		ANKY2_HUMAN (1-441): 2.17e-107: 326: 100.00
+	Hs
		818875 ADCY8_HUMAN (247-619): 5.59e-74: 259: 21.47		ANKY2_HUMAN (1-441): 2.17e-107: 326: 100.00
+	Hs
		243807 ADCY3_HUMAN (345-609): 1.84e-66: 237: 24.13		ANKY2_HUMAN (1-441): 2.17e-107: 326: 100.00
+	Hs
		250111 ADCY9_HUMAN (358-597): 8.27e-20: 96.3: 27.78		ANKY2_HUMAN (1-441): 2.17e-107: 326: 100.00