Protein: ADCY6
Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase)

Gene: ADCY6
Organism: Homo sapiens
Interactions: 58
UniProt ID: O43306

Gene Ontology (top 5):
GO:0003091 - renal water homeostasis
GO:0004016 - adenylate cyclase activity
GO:0005080 - protein kinase C binding
GO:0005524 - ATP binding
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

213327

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

2

5

High-throughput

0.811

High

127223

LEG8
Galectin-8

3

9

High-throughput

0.667

High

213306

LEG3
Galectin-3

3

9

High-throughput

0.667

High

213325

S39A4
Zinc transporter ZIP4

3

0

High-throughput

0.638

High

213295

B4GA1
Beta-1,4-glucuronyltransferase 1

3

0

High-throughput

0.634

High

213329

SPG16
Sperm-associated antigen 16 protein

1

1

High-throughput

0.618

High

213346

NGN3
Neurogenin-3

3

1

High-throughput

0.604

High

213309

CD70
CD70 antigen

2

0

High-throughput

0.602

High

213338

YIPF3
Protein YIPF3

2

0

High-throughput

0.602

High

213341

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.602

High

213303

RASK
GTPase KRas

2

7

High-throughput

0.584

High

213334

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

2

High-throughput

0.574

High

213323

DCAF6
DDB1- and CUL4-associated factor 6

1

1

High-throughput

0.553

High

127615

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

1

High-throughput

0.536

High

190283

COPT1
High affinity copper uptake protein 1

1

2

High-throughput

0.536

High

213297

EXTL3
Exostosin-like 3

1

1

High-throughput

0.536

High

213298

O10H2
Olfactory receptor 10H2

1

3

High-throughput

0.536

High

213301

TSN15
Tetraspanin-15

1

2

High-throughput

0.536

High

213305

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

4

High-throughput

0.536

High

213311

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

4

High-throughput

0.536

High

213324

TTMP
TPA-induced transmembrane protein

1

2

High-throughput

0.536

High

213331

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.536

High

213333

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

1

High-throughput

0.536

High

213335

CLC2B
C-type lectin domain family 2 member B

1

1

High-throughput

0.536

High

213336

LPAR1
Lysophosphatidic acid receptor 1

1

2

High-throughput

0.536

High

213339

TTYH1
Protein tweety homolog 1

1

2

High-throughput

0.536

High

213343

KCMB3
Calcium-activated potassium channel subunit beta-3

1

1

High-throughput

0.536

High

213347

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

179095

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

0

Small-scale

0.517

High

213344

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.515

High

213315

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

213320

GRIK5
Glutamate receptor ionotropic, kainate 5

1

0

High-throughput

0.513

High

213322

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.513

High

213326

AEGP
Apical endosomal glycoprotein

1

0

High-throughput

0.513

High

213337

TMM74
Transmembrane protein 74

1

0

High-throughput

0.513

High

213340

MANS1
MANSC domain-containing protein 1

1

0

High-throughput

0.513

High

213321

LEG9B
Galectin-9B

1

9

High-throughput

0.489

High

213302

RASH
GTPase HRas

1

4

High-throughput

0.479

High

213304

RHOC
Rho-related GTP-binding protein RhoC

1

10

High-throughput

0.479

High

213310

ACHA7
Neuronal acetylcholine receptor subunit alpha-7

1

4

Small-scale

0.479

High

213314

RHOB
Rho-related GTP-binding protein RhoB

1

12

High-throughput

0.479

High

213316

CAV1
Caveolin-1

1

4

Small-scale

0.479

High

213296

TNF12
Tumor necrosis factor ligand superfamily member 12

1

0

High-throughput

0.458

High

213317

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

213308

CTR1
High affinity cationic amino acid transporter 1

1

3

High-throughput

0.445

High

213313

CD81
CD81 antigen

1

2

High-throughput

0.445

High

213319

SL9A5
Sodium/hydrogen exchanger 5

1

3

High-throughput

0.445

High

213342

ANKH
Mineralization regulator ANKH

1

1

High-throughput

0.445

High

213345

S12A4
Solute carrier family 12 member 4

1

6

High-throughput

0.445

High

174462

TRI66
Tripartite motif-containing protein 66

1

1

High-throughput

0.437

High

213300

LAT3
Large neutral amino acids transporter small subunit 3

1

0

High-throughput

0.426

High

213307

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

0

High-throughput

0.426

High

213318

TRDN
Triadin

1

0

High-throughput

0.426

High

213332

ZNT7
Zinc transporter 7

1

3

High-throughput

0.407

High

213330

SYNE4
Nesprin-4

3

0

High-throughput

0.347

High

213299

NIPS2
Protein NipSnap homolog 2

2

0

High-throughput

0.305

High

213312

ATX1
Ataxin-1

1

0

High-throughput

0.265

Low

213328

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025